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Fig. 6 | Diagnostic Pathology

Fig. 6

From: Expression of immune checkpoint regulators, programmed death-ligand 1 (PD-L1/PD-1), cytotoxic T lymphocyte antigen 4 (CTLA-4), and indolaimine-2, 3-deoxygenase (IDO) in uterine mesenchymal tumors

Fig. 6

Staining reactions in endometrial stromal sarcoma. H&E stain of a case of a uterine endometrial stromal sarcoma showing unform malignant stromal cells containing mitotic figures (arrowheads). The corresponding PD-L1 stain shows a single tumor cell with the cell membrane reactivity and CTLA-4 IHC displaying positive granular cytoplasmic staining of the malignant cells which are very similar to that in the control tissue as seen in Fig. 1 (case# 63, Additional Table 1). (20 × objective, insets: 60 × objective). Abbreviations: H&E, hematoxylin & eosin; PD-L1, programmed death-ligand 1; CTLA-4, cytotoxic T lymphocyte antigen 4

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Diagnostic Pathology

ISSN: 1746-1596

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