Fig. 3

Immunohistochemical features of the DICER1-associated central nervous system sarcoma. Desmin highlighted myogenic differentiation (a). DICER1 protein expressed in the majority of tumor cells (b). S100 immunohistochemistry was positive (c). Strong Syn immunostaining was observed in a significant number of tumor cells (d). MAP2 expressed in majority of neoplastic cells (e). NFP immunostaining was positive in some tumor cells (f). The nuclear positivity of H3K27me3 staining indicated no loss of (g). Tumor cells were negative for GFAP (h). There were a large of reticulin fibres (i). All images were taken at a magnification of 200 ×