Fig. 4From: An integrative bioinformatics investigation and experimental validation of critically involved genes in high-grade gliomasProtein–protein interaction network illustrated by Cytoscape software. The 25 genes of the top 20 DEGs interact with each other amongst them TIMP1, CHI3L1 and PTX3 have the most interactions. The green nodes represent upregulated genes, whereas nodes in red represent down-regulated genes. The Yellow circles contain upregulated hub DEGs with interactions to PTX3. Transcription factors are in triangular shape. The arrows represent the direction of interactionsBack to article page