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Table 5 Immunohisochemical staining pattern of p53 according to MDM2 amplification status

From: p53 immunostaining pattern is a useful surrogate marker for TP53 gene mutations

 

MDM2 amplification status

No amplification

Amplification

Null type

27 (22.0)

1 (8.3)a

Usual

13 (10.6)

8 (66.7)

Overexpression

83 (67.5)

3 (25.0)

Total

123

12

  1. The corresponding percentages are shown in parentheses
  2. a This case harbored TP53 compound R337C and E204Gfs*43 mutations and classified as DISRUPTED in main analysis