Table 2 Correlation analysis between HAMP and markers of immune cells in TIMER and GEPIA
From: High Hepcidin expression predicts poor prognosis in patients with clear cell renal cell carcinoma
Cell type | Gene marker | None | Purity | Tumor | Normal | ||||
|---|---|---|---|---|---|---|---|---|---|
Cor | P | Cor | P | R | P | R | P | ||
B cell | CD19 | 0.376 | **** | 0.337 | **** | 0.031 | 0.48 | 0.22 | 0.06 |
| Â | CD38 | 0.425 | **** | 0.411 | **** | 0.37 | **** | 0.32 | ** |
CD8+ T cell | CD8A | 0.382 | **** | 0.353 | **** | 0.22 | **** | 0.48 | **** |
| Â | CD8B | 0.406 | *** | 0.337 | **** | 0.17 | **** | 0.74 | **** |
Tfh | ICOS | 0.383 | **** | 0.359 | **** | 0.24 | **** | 0.49 | **** |
| Â | CXCR5 | 0.437 | **** | 0.408 | **** | 0.085 | 0.052 | 0.26 | * |
Th1 | STAT4 | 0.220 | **** | 0.185 | **** | 0.091 | * | 0.48 | **** |
| Â | STAT1 | 0.307 | **** | 0.277 | **** | 0.35 | **** | 0.15 | 0.2 |
|  | IFN-γ (IFNG) | 0.391 | **** | 0.365 | **** | 0.35 | **** | 0.29 | * |
|  | TNF-α (TNF) | 0.249 | **** | 0.219 | **** | 0.1 | * | 0.25 | * |
Th2 | CCR3 | 0.335 | **** | 0.315 | **** | 0.15 | *** | 0.36 | ** |
| Â | STAT5A | 0.395 | **** | 0.373 | **** | 0.23 | **** | 0.46 | **** |
Th9 | IRF4 | 0.426 | **** | 0.393 | **** | 0.24 | **** | 0.63 | **** |
| Â | SPI1 | 0.655 | **** | 0.639 | **** | 0.47 | **** | 0.59 | **** |
Th17 | IL-21R | 0.418 | **** | 0.362 | **** | 0.47 | **** | 0.6 | **** |
| Â | IL-23R | 0.218 | **** | 0.171 | *** | 0.12 | ** | 0.59 | **** |
Th22 | CCR10 | -0.045 | 0.302 | -0.113 | 0.015 | -0.073 | 0.097 | 0.17 | 0.15 |
| Â | AHR | -0.0828 | 0.058 | -0.113 | 0.501 | 0.04 | 0.36 | 0.37 | ** |
Treg | FOXP3 | 0.501 | **** | 0.482 | **** | 0.29 | **** | 0.41 | *** |
| Â | CD25(IL2RA) | 0.404 | **** | 0.378 | **** | 0.51 | **** | 0.42 | *** |
| Â | CCR8 | 0.385 | **** | 0.359 | **** | 0.21 | **** | 0.46 | **** |
T cell exhaustion | PD-1 | -0.0138 | 0.761 | -0.039 | 0.403 | 0.084 | 0.055 | 0.12 | 0.3 |
| Â | PDCD1 | 0.430 | **** | 0.409 | **** | 0.2 | **** | 0.42 | **** |
| Â | CTLA4 | 0.381 | **** | 0.356 | **** | 0.22 | **** | 0.36 | ** |
| Â | LAG3 | 0.439 | **** | 0.415 | **** | 0.3 | **** | 0.24 | * |
| Â | TIM-3(HAVCR2) | 0.139 | 0.001 | 0.115 | 0.014 | -0.0056 | 0.9 | 0.22 | 0.058 |
| Â | PDCD1LG2 | 0.269 | **** | 0.228 | **** | 0.21 | **** | 0.25 | * |
| Â | SIGLEC15 | 0.302 | **** | 0.307 | **** | 0.026 | 0.55 | 0.099 | 0.41 |
| Â | TIGIT | 0.418 | **** | 0.398 | **** | 0.28 | **** | 0.39 | *** |
Macrophage | CD68 | 0.456 | **** | 0.477 | **** | 0.3 | **** | 0.6 | **** |
| Â | CD11b(ITGAM) | 0.434 | **** | 0.426 | **** | 0.12 | ** | 0.6 | **** |
M1 | INOS(NOS2) | -0.273 | **** | -0.332 | **** | -0.11 | * | 0.12 | 0.32 |
| Â | IRF5 | 0.274 | **** | 0.273 | **** | 0.19 | **** | -0.037 | **** |
| Â | COX2(PTGS2) | 0.062 | 0.151 | 0.017 | 0.710 | -0.021 | 0.64 | 0.082 | 0.49 |
M2 | ARG1 | -0.010 | * | -0.081 | 0.081 | -0.022 | 0.61 | 0.17 | 0.16 |
| Â | MS4A4A | 0.412 | **** | 0.386 | **** | 0.37 | **** | 0.48 | **** |
TAM | CD80 | 0.479 | **** | 0.452 | **** | 0.43 | **** | 0.34 | ** |
| Â | CD86 | 0.546 | **** | 0.537 | **** | 0.45 | **** | 0.49 | **** |
| Â | CCR5 | 0.456 | **** | 0.440 | **** | 0.33 | **** | 0.56 | **** |
Monocyte | CD14 | 0.598 | **** | 0.573 | **** | 0.61 | **** | 0.52 | **** |
| Â | CD115(CSF1R) | 0.443 | **** | 0.419 | **** | 0.45 | **** | 0.53 | **** |
Neutrophil | CD66b(CEACAM8) | -0.107 | 0.013 | -0.103 | 0.026 | -0.0014 | 0.98 | 0.023 | 0.85 |
| Â | CD15(FUT4) | 0.033 | 0.447 | -0.016 | 0.727 | 0.17 | *** | 0.32 | ** |
Natural killer cell | XCL1 | 0.432 | **** | 0.400 | **** | 0.17 | *** | 0.41 | *** |
| Â | CD7 | 0.413 | **** | 0.381 | **** | 0.029 | 0.5 | 0.65 | **** |
Dendritic cell | CD11c(ITGAX) | 0.461 | **** | 0.462 | **** | 0.17 | **** | 0.52 | **** |