Table 2 Review of reported molecular alterations of IOPN
References | Upregulated gene | Fusion | Loss of heterozygosity | Amplification | Gene mutation | Origin |
|---|---|---|---|---|---|---|
Xiao et al. [10] | KRAS, BRAF | Pancreas | ||||
Mohri et al. [11] | KRAS | Pancreas | ||||
Schlitter et al. [12] | P16 | Bile Duct | ||||
Amato et al. [6] | GNAS, KRAS | Pancreas | ||||
Basturk et al. [13] | ARHGAP26, ASXL1, EPHA8, ERBB4 | Pancreas | ||||
Singhi et al. [5] | ATP1B1-PRKACA, ATP1B1-PRKACB, DNAJB1-PRKACA | Pancreas, Bile Duct | ||||
Vyas et al. [18] | DNAJB1-PRKACA, PRKACA-ATP1B1 | Pancreas, Bile Duct | ||||
Aoki et al. [14] | TP53, KRAS, PBRM1, ELF3, NF1, BAP1, EPHA6, ERBB3, KMT2D, CDKN2A | Bile Duct | ||||
Nakahodo et al. [15] | Follistatin (FST) | Pancreas, Bile Duct | ||||
Chang et al. [16] | KRAS | Pancreas | ||||
Omori et al. [8] | P16 | STK11, KRAS, P53, SMAD4 | Pancreas | |||
Maimaitiaili et al. [17] | ATP1B1-PRKACA, DNAJB1-PRKACA ATP1B1-PRKACB | KRAS | Pancreas, Bile Duct | |||
This case | EGFR | STK11, GNAS | Bile Duct |