Fig. 2
SNHG15 enhances DDP resistance in A549/CR cells. A SNHG15 expression in A549/CS and A549/CR cells assessed by qRT-PCR. B IC50 values of DDP in A549/CS and A549/CR cells evaluated through CCK-8 assay. C SNHG15 expression in A549/CR cells transfected with sh-NC and sh-SNHG15 determined by qRT-PCR. D IC50 values of DDP in A549/CR cells transfected with sh-NC and sh-SNHG15 evaluated through CCK-8 assay. E DNA damage in DDP-treated (3 µg/mL) A549/CR cells transfected with sh-NC and sh-SNHG15 observed by comet assay. (Scale bar: 20 µm) (F) Immunofluorescence assay was performed to assess γH2AX production in DDP-treated (3 µg/mL) A549/CR cells transfected with sh-NC and sh-SNHG15, and photographs were taken by using confocal microscopy. (Scale bar: 20 µm) (* indicates P < 0.05)