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Fig. 3 | Diagnostic Pathology

Fig. 3

From: SNHG15 enhances cisplatin resistance in lung adenocarcinoma by affecting the DNA repair capacity of cancer cells

Fig. 3

SNHG15 up-regulated ECE2 expression through recruiting E2F1. A Correlation analysis between SNHG15 and downstream transcription factors. B Correlation analysis of SNHG15 with E2F1 and ECE2. C Protein interaction score of SNHG15 and E2F1 predicted through RPISeq database. D The binding ability of SNHG15 and TF E2F1 verified through RIP assay. E Box plot of ECE2 expression in LUAD, red indicated normal tissues and green indicated tumor tissues. F Survival analysis of LUAD patients with high and low ECE2 expression. G JASPAR database was applied for predicting the binding sequences of ECE2 promoter region and E2F1. H, I Dual-luciferase and ChIP assays was performed to determine the binding of E2F1 and ECE2 promoter region. J, K ECE2 expression in A549/CS and A549/CR cell lines assessed through qRT-PCR and Western blot. L, M ECE2 expression in A549/CR cells transfected with sh-NC and sh-SNHG15 evaluated through qRT-PCR and Western blot. (* indicates P < 0.05)

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