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Fig. 2 | Diagnostic Pathology

Fig. 2

From: CIN grades possessing different HPV RNA location patterns and RNAscope is helpful tool for distinguishing squamous intraepithelial lesions in difficult cervical cases

Fig. 2

The H&E morphology, P16/Ki67 phenotype and RNAscope expression patterns in Test-A group. Row1 (a-d): In P16- CIN1 case, RNAscope show diffuse clustered expression pattern in nuclei/cytoplasmic, staining areas is mainly located on the surface epithelium (d). Row2 (e–h): P16- CIN1 cases but RNAscope is negative (h). Row3 (i-l): In P16- CIN2 case, RNAscope show diffuse cluster positivity and cytoplasmic punctate positivity in superficial cells and scattered punctate positivity in basal and parabasal nuclei/cytoplasmic (l). Row4 (m-p): In P16- CIN3 case, RNAscope show dotted full-thickness nucleus/cytoplasmic scattered staining (p, arrow)

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