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Fig. 3 | Diagnostic Pathology

Fig. 3

From: CIN grades possessing different HPV RNA location patterns and RNAscope is helpful tool for distinguishing squamous intraepithelial lesions in difficult cervical cases

Fig. 3

The H&E morphology, P16/Ki67 phenotype and RNAscope expression patterns in Test-B group. Row1 (a-d): In CIN1 case with low expression of Ki67, RNAscope show diffuse clustered expression pattern in nuclei/cytoplasmic, and the staining areas is mainly located on the surface epithelium (d). Row2 (e–h): In case originally diagnosed as CIN2 with low expression of Ki67, RNAscope show dotted full-thickness nucleus/cytoplasmic scattered staining (h, arrow). Row3 (i-l): In CIN3 cases with low expression of Ki67, RNAscope show dotted full-thickness nucleus/cytoplasmic scattered staining (l, arrow)

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Diagnostic Pathology

ISSN: 1746-1596

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