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Table 3 TAP scoring precision for determining PD-L1 expression level in the external study (including borderline cases)

From: Tumor Area Positivity (TAP) score of programmed death-ligand 1 (PD-L1): a novel visual estimation method for combined tumor cell and immune cell scoring

Strata

Statistics

Agreement

Site A

APA %

80.7

n/N

88/109

95% CI

63.6–93.5

ANA %

87.3

n/N

144/165

95% CI

78.0–95.7

OPA %

84.7

n/N

116/137

95% CI

73.2–94.9

Site B

APA %

100.0

n/N

140/140

95% CI

97.3–100.0

ANA %

100.0

n/N

140/140

95% CI

97.3–100.0

OPA %

100.0

n/N

140/140

95% CI

97.3–100.0

Site C

APA %

100.0

n/N

140/140

95% CI

97.3–100.0

ANA %

100.0

n/N

140/140

95% CI

97.3–100.0

OPA %

100.0

n/N

140/140

95% CI

97.3–100.0

Combined

APA %

94.6

n/N

368/389

95% CI

90.8–98.0

ANA %

95.3

n/N

424/445

95% CI

91.5–98.5

OPA %

95.0

n/N

396/417

95% CI

91.2–98.3

  1. Counts indicate the number of pairwise comparisons and do not represent the number of unique cases
  2. ANA Average negative agreement, APA Average positive agreement, CI Confidence interval, OPA Overall percent agreement, PD-L1 Programmed death-ligand 1, TAP Tumor Area Positivity