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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Mediastinal high-grade vasculogenic mesenchymal tumour with seminoma: a case report and literature review

Fig. 2

Microscopic morphology and immunohistochemical characteristics of the tumour. (A) Spindle to stellate cells in a myxoid stroma. (B) Atypical cells form cleft-like spaces in which erythrocyte clusters can be seen. (C) Mitosis and individual erythrocytes within intracytoplasmic lumens. (D) Thin-walled blood vessels were formed. (E) Plexuses of vessels were anastomosed with a collagenized stroma. (F) Atypical seminoma cell clusters with clear cytoplasm were seen in the lymphoid stroma. (G) Spindle cells lining along clefts in myxoid stroma were positive for CD34. (H) ERG was expressed in endothelial cells. (I) The stellate cells around the clefts expressed SMA, while the lining cells were negative. (J) SMA expression was observed around the thin-walled small blood vessels, whereas the endothelial cells were negative. K) SALL4 was positive in the seminoma. L) PLAP was positive in the seminoma

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