Table 3 Clinical studies in which predictive and prognostic roles of PLT, MPV, and PDW were evaluated in patients with LSCC
From: Role and research progress of hematological markers in laryngeal squamous cell carcinoma
Year | Author | Case | Object | Platelet parameters | Cut-off value | Conclusion |
|---|---|---|---|---|---|---|
2017 | Pardo et al. [121] | 824 | HNSCC | PLT | PLT: 250.05 × 109/L | PLT was significantly associated with survival in univariate analysis. However, in a multivariate analysis it lost its prognostic capacity, limiting its utility as a prognostic marker in patients with HNSCC |
2017 | Zhang et al. [112] | 241 | LC | PDW | PDW: 16.7% | Elevated PDW might be a novel prognostic marker in laryngeal cancer |
2018 | Fu et al. [122] | 618 | LC, BLL, CG | MPV, PDW | - | The patients with LC have reduced MPV and increased PDW compared to the subjects without LC. In addition, MPV and PDW play different roles in LC from benign laryngeal disease |
2019 | Kara et al. [124] | 453 | BLL, PLL, and LSCC | PDW | - | Caution should be exercised when using these new hematological parameters, which can be affected by many factors |
2019 | Sheng et al. [51] | 110 | underwent surgical resection for LSCC | MPV | MPV: 9.5fL | Preoperative increased MPV was associated with reduced prognosis in patients with LSCC |
2020 | Ye et al. [54] | 197 | HNSCC | PLT | PLT: 248 × 109/L | Pre-treatment PLT > 248 × 109/L is a promising predictor of prognosis in patients with operable HNSCC |
2021 | Guo et al. [123] | 640 | LC | MPV, PDW | - | Elevated PDW and decreased MPV could serve as independent biomarkers for worse survival in LC |