Fig. 1

Case 1. A-B. PET/CT shows a large tumoral mass at the upper-external quadrant of the right breast, in close contact with the implant with a layer of fluid surrounding the implant; There were no lymphadenopathies nor other suspicious PET-positive lesions. C-D. Low power view of the H&E of the tumor mass, composed of diffuse sheets of large atypical lymphoid cells. E. High power field view of HE of large malignant cells expressing CD30 (F), CD15 (G), but no T-cell markers, such as CD4 (H). The cells did express B-cell markers PAX5 (I), CD20 (J), OCT2 (K), CD79A (L) and were positive for EBER (M); The expression of LMP1 (N) and EBNA2 (O) indicate EBV viral latency type III; The tumor microenvironment is nearly absent, but the tumor cells diffusely express PD-L (P)