Fig. 2

Case 2. A. MRI shows intact breast implants, and a thick-walled fluid collection with intralesional septations, but no contrast capturing, medially of the implant in the left breast; B. FNAC cytology shows large atypical cells (Papanicolaou stain), expressing CD30 and PAX5 (not shown); C. HE stain of the left capsulectomy specimen, showing a fibrous capsule (ca) with a fibrinous cover (fc), containing clusters of large atypical lymphoid cells (square in D, enlarged in D-E), expressing CD30 (F), and B-cell markers CD20 (G), OCT2, PAX5 and BOB1, and also the hypoxia marker CA-9 (H); Presence of EBV was shown by EBER ISH (I), displaying an EBV latency type III, with expression of LMP1 (J) and EBNA2 (K); There was no T-cell marker expression, but the cells were positive for PD-L1 (L)