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  1. Desmoplastic small round cell tumor (DSRCT) is a rare soft tissue tumor that generally involves the retroperitoneum, pelvis, omentum and mesentery in younger patients. However, extra-abdominal DSRCT is very rare.

    Authors: Kanako C. Hatanaka, Emi Takakuwa, Yutaka Hatanaka, Akira Suzuki, Satoshi IIzuka, Nayuta Tsushima, Tomoko Mitsuhashi, Shintaro Sugita, Akihiro Homma, Shojiroh Morinaga, Tadashi Hashegawa and Yoshihiro Matsuno

    Citation: Diagnostic Pathology 2019 14:43

    Content type: Case Report

    Published on:

  2. According to WHO, succinate dehydrogenase (SDH)–deficient renal cell carcinoma is characterized by negative immunostaining for SDHB, which remains positive in non-tumor tissue despite germline mutations in the SD...

    Authors: Marina Ugarte-Camara, Raul Fernandez-Prado, Isabel Lorda, Gabriela Rossello, Carmen Gonzalez-Enguita, Pablo Cannata-Ortiz and Alberto Ortiz

    Citation: Diagnostic Pathology 2019 14:42

    Content type: Case Report

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  3. Lipoprotein glomerulopathy (LPG) is a rare kidney disease with a poor prognosis that is related to mutation of the apoE gene. More than 10 variants of apoE associated with LPG have currently been identified.

    Authors: Weiji Xie, Yi Xie, Zhijun Lin, Xiaochang Xu and Yimin Zhang

    Citation: Diagnostic Pathology 2019 14:41

    Content type: Case Report

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  4. Henoch-Schönlein purpura nephritis (HSPN) shares many similarities with IgA nephropathy. We aimed to analyze the predictive value of the International Study of Kidney Disease in Children (ISKDC) classification...

    Authors: Xiaohan Huang, Lili Ma, Pingping Ren, Hongya Wang, Liangliang Chen, Haidongqin Han, Jianghua Chen and Fei Han

    Citation: Diagnostic Pathology 2019 14:40

    Content type: Research

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  5. One of the major challenges remaining in the classification of thyroid tumor is the determination of whether a nodule is benign or malignant. We aimed to characterize the mutational profiles of follicular thyr...

    Authors: Huanli Duan, Xiaoding Liu, Xinyu Ren, Hui Zhang, Huanwen Wu and Zhiyong Liang

    Citation: Diagnostic Pathology 2019 14:39

    Content type: Research

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  6. Gastric mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are infrequently encountered in routine practice. Some gastric neuroendocrine carcinomas (NECs) have a variety of differentiation patterns; ho...

    Authors: Yasuko Fujita, Noriyuki Uesugi, Ryo Sugimoto, Makoto Eizuka, Takayuki Matsumoto and Tamotsu Sugai

    Citation: Diagnostic Pathology 2019 14:38

    Content type: Case Report

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  7. Diagnoses reflect clear cell morphologies when tumor cells have clear cytoplasm in many organs, and the nature of such clear cells is typically identified. Colorectal tubular adenoma or adenocarcinoma, convers...

    Authors: Yuzo Oyama, Haruto Nishida, Takahiro Kusaba, Hiroko Kadowaki, Motoki Arakane, Kazuhisa Okamoto, Junpei Wada, Shogo Urabe and Tsutomu Daa

    Citation: Diagnostic Pathology 2019 14:37

    Content type: Case Report

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  8. DNA mismatch repair (MMR) deficiency is a major pathway of genomic instability in cancer. It leads to the accumulation of numerous mutations predominantly at microsatellite sequences, a phenotype known as micr...

    Authors: Benjamin Goeppert, Stephanie Roessler, Marcus Renner, Moritz Loeffler, Stephan Singer, Melina Rausch, Thomas Albrecht, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil, Elena Czink, Bruno Köhler, Christoph Springfeld, Christian Rupp, Karl Heinz Weiss, Peter Schirmacher…

    Citation: Diagnostic Pathology 2019 14:36

    Content type: Research

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  9. The concordance rate of human epidermal growth factor receptor 2 (HER2) status between core needle biopsy (CNB) and subsequent excisional biopsies of the same tumor varies from 81 to 96%, which may cause inapp...

    Authors: Huimin Zhang, Peiling Xie, Zhuoying Li, Rong Huang, Weiliang Feng, Yanan Kong, Feng Xu, Lin Zhao, Qingkun Song, Jing Li, Baoning Zhang, Jinhu Fan, Youlin Qiao, Xiaoming Xie, Shan Zheng, Jianjun He…

    Citation: Diagnostic Pathology 2019 14:35

    Content type: Research

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  10. Desmoid-type fibromatosis (DTF) is a lesion characterized by clonal proliferation of myofibroblasts, which exhibits an infiltrative growth pattern. It is necessary for them to be distinguished from other fibro...

    Authors: Luting Zhou, Haimin Xu, Jun Zhou, Lei Dong, Peipei Zhang, Xiaoqun Yang and Chaofu Wang

    Citation: Diagnostic Pathology 2019 14:34

    Content type: Research

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  11. SNW1 is a nuclear receptor co-activator involved in splicing and transcription control, including androgen receptor signaling. Overexpression of SNW1 has been linked to adverse prognosis in different cancer ty...

    Authors: Doris Höflmayer, Carla Willich, Claudia Hube-Magg, Ronald Simon, Dagmar Lang, Emily Neubauer, Frank Jacobsen, Andrea Hinsch, Andreas M. Luebke, Marie Christina Tsourlakis, Hartwig Huland, Markus Graefen, Alexander Haese, Hans Heinzer, Sarah Minner, Franziska Büscheck…

    Citation: Diagnostic Pathology 2019 14:33

    Content type: Research

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  12. Uterine leiomyomas, in contrast to sarcomas, tend to cease growth following menopause. In the setting of a rapidly enlarging uterine mass in a postmenopausal patient, clinical distinction of uterine leiomyoma ...

    Authors: Alessandra J. Ainsworth, Nooshin K. Dashti, Taofic Mounajjed, Karen J. Fritchie, Jaime Davila, Rohini Mopuri, Rory A. Jackson, Kevin C. Halling, Jamie N. Bakkum-Gamez and J. Kenneth Schoolmeester

    Citation: Diagnostic Pathology 2019 14:32

    Content type: Case Report

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  13. Linear Array Genotyping Test (LA) is one of the gold standards used for Human Papillomavirus (HPV) genotyping, however, since its launching in 2006, new HPV genotypes are still being characterized with the use...

    Authors: Cristina Artaza-Irigaray, María Guadalupe Flores-Miramontes, Dominik Olszewski, Verónica Vallejo-Ruiz, Laura Patricia Limón-Toledo, Cibeles Sánchez-Roque, Rocío Mayoral-Torres, Luis Felipe Jave-Suárez and Adriana Aguilar-Lemarroy

    Citation: Diagnostic Pathology 2019 14:31

    Content type: Research

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  14. Metastatic tumors to the pancreas are uncommon, accounting for approximately 2% of pancreatic malignancies. The most common primary tumors to give rise to pancreatic metastases are carcinomas.

    Authors: Aoife J. McCarthy, Blaise A. Clarke, Ian McGilvray, Brendan C. Dickson, Korosh Khalili and Runjan Chetty

    Citation: Diagnostic Pathology 2019 14:30

    Content type: Case Report

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  15. Insights into the molecular underpinnings of primary central nervous system tumors have radically changed the approach to tumor diagnosis and classification. Diagnostic emphasis has shifted from the morphology...

    Authors: Matthew D. Wood, Aaron M. Halfpenny and Stephen R. Moore

    Citation: Diagnostic Pathology 2019 14:29

    Content type: Review

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  16. Orthokeratinized Odontogenic Cyst (OOC) is a rare, developmental odontogenic cyst which was considered in the past to be a variant of Odontogenic keratocyst (OKC) later renamed as keratocystic odontogenic tumo...

    Authors: Nasir Uddin, Maha Zubair, Jamshid Abdul-Ghafar, Zia Ullah Khan and Zubair Ahmad

    Citation: Diagnostic Pathology 2019 14:28

    Content type: Research

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  17. Ovarian Sertoli-Leydig cell tumors (SLCTs) with androgenic manifestations harbor DICER1 mutations in 30–60% of cases. Ovarian SLCTs without DICER1 hotspot mutations have been reported to exhibit elderly onset and...

    Authors: Mitsumasa Osakabe, Chie Sato, Masamichi Suzuki, Ryo Sugimoto, Yasuko Fujita, Noriyuki Uesugi, Kazuyuki Ishida, Hiroaki Itamochi, Tsukasa Baba and Tamotsu Sugai

    Citation: Diagnostic Pathology 2019 14:27

    Content type: Case Report

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  18. Myeloid sarcoma (MS) is a rare neoplasm of immature myeloid precursors that form tumor mass outside the bone marrow. The diagnosis of de novo MS can be challenging, particularly in patients with no prior histo...

    Authors: Haiyan Bao, Juehua Gao, Yi-Hua Chen, Jessica K. Altman, Olga Frankfurt, Amanda L. Wilson, Madina Sukhanova, Qing Chen and Xinyan Lu

    Citation: Diagnostic Pathology 2019 14:26

    Content type: Case Report

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  19. Histopathological analysis is the cornerstone in bladder cancer (BCa) diagnosis. These analysis suffer from a moderate observer agreement in the staging of bladder cancer. Three-dimensional reconstructions hav...

    Authors: Ilaria Jansen, Marit Lucas, C. Dilara Savci-Heijink, Sybren L. Meijer, Esmee I. M. L. Liem, Onno J. de Boer, Ton G. van Leeuwen, Henk A. Marquering and Daniel M. de Bruin

    Citation: Diagnostic Pathology 2019 14:25

    Content type: Research

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  21. Previous studies reported the early diagnostic values of plasma Epstein-Barr virus (EBV)-DNA. The present study aimed to assess the relationship between the concentration of plasma EBV-DNA and the number of CD8+P...

    Authors: Qi Chen, Wei Hu, Huacai Xiong, Shenpeng Ying, Yanyun Ruan, Bo Wu and Hongsheng Lu

    Citation: Diagnostic Pathology 2019 14:23

    Content type: Research

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  22. Malakoplakia is a chronic inflammatory disease characterized by tissue infiltrates of large granular macrophages containing distinctive intracytoplasmic inclusions termed Michaelis-Gutmann (MG) bodies. The gen...

    Authors: Andrew Mitchell and Alexandre Dugas

    Citation: Diagnostic Pathology 2019 14:22

    Content type: Case Report

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  23. A giant congenital melanocytic nevus (GCMN) is found in 0.1% of live-born infants. If present, the lesion has a chance of about 6% to develop into malignant melanoma. Both children and adults can be affected b...

    Authors: Tatiana S. Belysheva, Yana V. Vishnevskaya, Tatiana V. Nasedkina, Marina A. Emelyanova, Ivan S. Abramov, Kristina V. Orlova, Ludmila N. Lubchenko, Igor A. Utyashev, Marina B. Doroshenko, Lev V. Demidov and Mamed D. Aliev

    Citation: Diagnostic Pathology 2019 14:21

    Content type: Case Report

    Published on:

  24. Solitary fibrous tumor (SFT) is a ubiquitous mesenchymal neoplasm but it rarely occurs in the parotid gland. The histological features are variable, with the majority having spindle cell morphology and non-spe...

    Authors: Chien-Kuan Lee, Ken-Liao Liu and Sheng-Kai Huang

    Citation: Diagnostic Pathology 2019 14:20

    Content type: Case Report

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  25. Laser-interstitial thermal therapy (LITT) has been supported by some authors as an ablative treatment of glioblastoma multiforme (GBM). Although the effects of LITT have been modeled in vivo, the histologic ef...

    Authors: J. Bradley Elder, Kristin Huntoon, Jose Otero, Behiye Kaya, Jeff Hatef, Mostafa Eltobgy and Russell R. Lonser

    Citation: Diagnostic Pathology 2019 14:19

    Content type: Case Report

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  26. Molecular testing of lung adenocarcinoma for oncogenic driver mutations has become standard in pathology practice. The aim of the study was to analyze the EGFR, KRAS, ALK, RET, ROS1, BRAF, ERBB2, MET and PIK3CA m...

    Authors: Alexandra Grosse, Claudia Grosse, Markus Rechsteiner and Alex Soltermann

    Citation: Diagnostic Pathology 2019 14:18

    Content type: Research

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  27. Retroperitoneal high-grade serous carcinoma (HGSC) is extremely rare and the origin remains unclear. We present a case of retroperitoneal HGSC and coexisting serous tubal intraepithelial carcinoma (STIC), whic...

    Authors: Kazuaki Suda, Hirofumi Nakaoka, Chihiro Hata, Natsumi Yahata, Masanori Isobe, Hitoshi Kameyama, Toshifumi Wakai, Teiichi Motoyama, Ituro Inoue, Kosuke Yoshihara and Takayuki Enomoto

    Citation: Diagnostic Pathology 2019 14:17

    Content type: Case Report

    Published on:

  28. Gliomas with 1p/19q-codeletion as well as mutation of isocitrate dehydrogenase (IDH) 1 are typically characterized as oligodendrogliomas with comparatively good response to treatment with radiation and chemothera...

    Authors: Carlos G. Romo, Doreen N. Palsgrove, Ananyaa Sivakumar, Christen R. Elledge, Lawrence R. Kleinberg, Kaisorn L. Chaichana, Christopher D. Gocke, Fausto J. Rodriguez and Matthias Holdhoff

    Citation: Diagnostic Pathology 2019 14:16

    Content type: Case Report

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  29. Intramuscular myxoma (IM) is a hypocellular benign soft tissue neoplasm characterized by abundant myxoid stroma and occasional hypercellular areas. These tumors can, especially on biopsy material, be difficult...

    Authors: Elise M. Bekers, Astrid Eijkelenboom, Paul Rombout, Peter van Zwam, Suzanne Mol, Emiel Ruijter, Blanca Scheijen and Uta Flucke

    Citation: Diagnostic Pathology 2019 14:15

    Content type: Research

    Published on:

  30. Adenoid cystic carcinoma (ACC) is a salivary gland malignancy with poor long-term survival, which warrants studies aimed at clarifying the pathogenesis of this disease in order to widen the scope of therapeuti...

    Authors: João Augusto Vianna Goulart-Filho, Victor Angelo Martins Montalli, Fabrício Passador-Santos, Ney Soares de Araújo and Vera Cavalcanti de Araújo

    Citation: Diagnostic Pathology 2019 14:14

    Content type: Research

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  31. Clear cell sarcoma of the kidney (CCSK) is a rare malignant pediatric renal neoplasm with a heterogeneous histological appearance which often results in misdiagnosis. There are no specific immunohistochemical ...

    Authors: Nasir Uddin, Khurram Minhas, Jamshid Abdul-Ghafar, Arsalan Ahmed and Zubair Ahmad

    Citation: Diagnostic Pathology 2019 14:13

    Content type: Research

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  32. Primary renal well-differentiated neuroendocrine tumors (WDNETs) also called carcinoid and atypical carcinoid are extremely rare, and little is known about parameters that may predict prognosis at diagnosis.

    Authors: Bohyun Kim, Han-Seong Kim and Kyung Chul Moon

    Citation: Diagnostic Pathology 2019 14:12

    Content type: Research

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  33. Circular RNAs (circRNAs) represent a class of widespread and variety endogenous RNAs that may regulate gene expression. Thousands of mammalian circRNAs harbor miRNA response elements (MREs), suggesting a poten...

    Authors: Xinyi Tang, Jiemin Wang, Xin Xia, Jie Tian, Ke Rui, Huaxi Xu and Shengjun Wang

    Citation: Diagnostic Pathology 2019 14:11

    Content type: Research

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  34. Pathological diagnosis based on core needle biopsy (CNB) should be different from a resected specimen because it is difficult to apply the histological criteria established for resected specimens to CNB due to...

    Authors: Yan Xiong, Limin Yan, Lin Nong, Yalin Zheng and Ting Li

    Citation: Diagnostic Pathology 2019 14:10

    Content type: Research

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  35. Pagetoid spread of urothelial carcinoma (UC) to the lower genital tract is quite a rare and diagnostically challenging condition. Pagetoid urothelial intraepithelial neoplasia extending to the vagina is diffic...

    Authors: Yuki Koyanagi, Chiaki Kubo, Shigenori Nagata, Ayumi Ryu, Koji Hatano, Rieko Kano, Satoshi Tanada, Jun-ichi Ashimura, Atsushi Idota, Shoji Kamiura, Tomoyuki Yamasaki and Shin-ichi Nakatsuka

    Citation: Diagnostic Pathology 2019 14:9

    Content type: Case Report

    Published on:

  37. Currently, ribosome-binding protein 1 (RRBP1) is considered to be a novel oncogene that is overexpressed in colorectal cancer, lung cancer, mammary cancer, esophageal cancer and other carcinomas. However, the ...

    Authors: Shuang Liu, Mu Lin, Hongying Ji, Jing Ding, Jiaqi Zhu, Rong Ma and Fanling Meng

    Citation: Diagnostic Pathology 2019 14:7

    Content type: Research

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  38. Programmed death ligand 1 (PD-L1) is a ligand for the inhibitory programmed cell death protein 1 (PD-1), which are targeted by several anti-PD-1 and PD-L1 drugs for a variety of human cancers. However, only a ...

    Authors: Lulu Rong, Yong Liu, Zhouguang Hui, Zitong Zhao, Yueming Zhang, Bingzhi Wang, Yanling Yuan, Wenbin Li, Lei Guo, Jianming Ying, Yongmei Song, Luhua Wang, Zhongren Zhou, Liyan Xue and Ning Lu

    Citation: Diagnostic Pathology 2019 14:6

    Content type: Research

    Published on:

  39. Mediastinal follicular dendritic cell sarcoma (FDCS) is extremely rare. Due to potential under-recognization of this disease, it happens to be misdiagnosed, especially on core needle biopsy. We report 3 cases ...

    Authors: You-Li Wu, Feng Wu, Cheng-Ping Xu, Guo-Lei Chen, Yu Zhang, Wei Chen, Xiao-Chu Yan and Guang-Jie Duan

    Citation: Diagnostic Pathology 2019 14:5

    Content type: Research

    Published on:

  40. High-grade serous carcinoma, a representative high-grade ovarian carcinoma, is believed to be closely associated with a TP53 mutation. Recently, this category of ovarian carcinoma has gained increasing attention ...

    Authors: Yuichiro Hatano, Maho Tamada, Nami Asano, Yoh Hayasaki, Hiroyuki Tomita, Ken-ichirou Morishige and Akira Hara

    Citation: Diagnostic Pathology 2019 14:4

    Content type: Case Report

    Published on:

  41. Lipopolysaccharide (LPS) from Helicobacter pylori (HP) plays an important role in gastric cancer occurrence and development. Toll-like receptor 4 (TLR4) and myeloid differential protein-2 (MD-2) are also reported...

    Authors: Nan Li, Huanbai Xu, Yurong Ou, Zhenzhong Feng, Qiong Zhang, Qing Zhu and Zhaogen Cai

    Citation: Diagnostic Pathology 2019 14:3

    Content type: Research

    Published on:

  42. Pathological features of prostate cancer in Korean men were analyzed to determine whether identification of tumor volume, Gleason score (GS), focality, and location using radical prostatectomy (RP) specimens c...

    Authors: Young Hyo Choi, Ji Woong Yu, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee and Hwang Gyun Jeon

    Citation: Diagnostic Pathology 2019 14:2

    Content type: Research

    Published on:

  43. Carcinomas composed predominantly or purely of malignant Paneth cells were rarely reported in gastrointestinal system. They have not been reported at gastroesophageal junction nor has the association with Barr...

    Authors: Wenyi Luo, Wayne L. Hofstetter and Dongfeng Tan

    Citation: Diagnostic Pathology 2019 14:1

    Content type: Case Report

    Published on:

  44. Epignathus is a rare congenital orofacial teratoma infrequently associated with intracranial extension. Intracranial extension of an epignathus indicates a poor prognosis; however, only a small number of such ...

    Authors: Mari Kirishima, Sohsuke Yamada, Mitsuhisa Shinya, Shun Onishi, Yuko Goto, Ikumi Kitazono, Tsubasa Hiraki, Michiyo Higashi, Akira I. Hida and Akihide Tanimoto

    Citation: Diagnostic Pathology 2018 13:99

    Content type: Case Report

    Published on:

  45. Alu repeats, belonging to the Short Interspersed Repetitive Elements (SINEs) class, contain about 25% of CpG sites in the human genome. Alu sequences lie in gene-rich regions, so their methylation is an import...

    Authors: Paola Orsini, Luciana Impera, Elisa Parciante, Cosimo Cumbo, Crescenzio F. Minervini, Angela Minervini, Antonella Zagaria, Luisa Anelli, Nicoletta Coccaro, Paola Casieri, Giuseppina Tota, Claudia Brunetti, Alessandra Ricco, Paola Carluccio, Giorgina Specchia and Francesco Albano

    Citation: Diagnostic Pathology 2018 13:98

    Content type: Research

    Published on:

  47. Rapid transmission and high mortality of Ebola virus disease (EVD) highlight a urgent need of large scale, convenient and effective measure for Ebola virus screening. Application of monoclonal antibodies (mAbs...

    Authors: Junjie Zai, Kai Yi, Lilan Xie, Jiping Zhu, Xiaoting Feng and Yaoming Li

    Citation: Diagnostic Pathology 2018 13:96

    Content type: Research

    Published on:

  48. Both Gram-Positive and Gram-Negative bacteria can secrete outer membrane vesicles (OMVs) in their growth and metabolism process. Originally, OMVs were considered as a by-product of bacterial merisis. However, ...

    Authors: Wei Cai, Dinesh Kumar Kesavan, Jie Wan, Mohamed Hamed Abdelaziz, Zhaoliang Su and Huaxi Xu

    Citation: Diagnostic Pathology 2018 13:95

    Content type: Review

    Published on:

  49. Erdheim Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis characterized by widespread tissue infiltration by CD68-positive, CD1a-negative foamy histiocytes. ECD can be difficult to identify, a...

    Authors: Hany I. Sakr, Kaila Buckley, Robert Baiocchi, Weiqiang John Zhao and Jessica A. Hemminger

    Citation: Diagnostic Pathology 2018 13:94

    Content type: Case Report

    Published on:

  50. Neoadjuvant chemotherapy (NACT) has been recently accepted as an effective alternative in patients with locally advanced cervical cancer. However, little is known about the effects of NACT on the immunological...

    Authors: Yun Liang, Weiguo Lü, Xiaofei Zhang and Bingjian Lü

    Citation: Diagnostic Pathology 2018 13:93

    Content type: Research

    Published on:

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Diagnostic Pathology

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