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  1. Content type: Research

    Circular RNAs (circRNAs) represent a class of widespread and variety endogenous RNAs that may regulate gene expression. Thousands of mammalian circRNAs harbor miRNA response elements (MREs), suggesting a poten...

    Authors: Xinyi Tang, Jiemin Wang, Xin Xia, Jie Tian, Ke Rui, Huaxi Xu and Shengjun Wang

    Citation: Diagnostic Pathology 2019 14:11

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  2. Content type: Research

    Pathological diagnosis based on core needle biopsy (CNB) should be different from a resected specimen because it is difficult to apply the histological criteria established for resected specimens to CNB due to...

    Authors: Yan Xiong, Limin Yan, Lin Nong, Yalin Zheng and Ting Li

    Citation: Diagnostic Pathology 2019 14:10

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  3. Content type: Case Report

    Pagetoid spread of urothelial carcinoma (UC) to the lower genital tract is quite a rare and diagnostically challenging condition. Pagetoid urothelial intraepithelial neoplasia extending to the vagina is diffic...

    Authors: Yuki Koyanagi, Chiaki Kubo, Shigenori Nagata, Ayumi Ryu, Koji Hatano, Rieko Kano, Satoshi Tanada, Jun-ichi Ashimura, Atsushi Idota, Shoji Kamiura, Tomoyuki Yamasaki and Shin-ichi Nakatsuka

    Citation: Diagnostic Pathology 2019 14:9

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  4. Content type: Research

    Currently, ribosome-binding protein 1 (RRBP1) is considered to be a novel oncogene that is overexpressed in colorectal cancer, lung cancer, mammary cancer, esophageal cancer and other carcinomas. However, the ...

    Authors: Shuang Liu, Mu Lin, Hongying Ji, Jing Ding, Jiaqi Zhu, Rong Ma and Fanling Meng

    Citation: Diagnostic Pathology 2019 14:7

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  5. Content type: Research

    Programmed death ligand 1 (PD-L1) is a ligand for the inhibitory programmed cell death protein 1 (PD-1), which are targeted by several anti-PD-1 and PD-L1 drugs for a variety of human cancers. However, only a ...

    Authors: Lulu Rong, Yong Liu, Zhouguang Hui, Zitong Zhao, Yueming Zhang, Bingzhi Wang, Yanling Yuan, Wenbin Li, Lei Guo, Jianming Ying, Yongmei Song, Luhua Wang, Zhongren Zhou, Liyan Xue and Ning Lu

    Citation: Diagnostic Pathology 2019 14:6

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  6. Content type: Research

    Mediastinal follicular dendritic cell sarcoma (FDCS) is extremely rare. Due to potential under-recognization of this disease, it happens to be misdiagnosed, especially on core needle biopsy. We report 3 cases ...

    Authors: You-Li Wu, Feng Wu, Cheng-Ping Xu, Guo-Lei Chen, Yu Zhang, Wei Chen, Xiao-Chu Yan and Guang-Jie Duan

    Citation: Diagnostic Pathology 2019 14:5

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  7. Content type: Case Report

    High-grade serous carcinoma, a representative high-grade ovarian carcinoma, is believed to be closely associated with a TP53 mutation. Recently, this category of ovarian carcinoma has gained increasing attention ...

    Authors: Yuichiro Hatano, Maho Tamada, Nami Asano, Yoh Hayasaki, Hiroyuki Tomita, Ken-ichirou Morishige and Akira Hara

    Citation: Diagnostic Pathology 2019 14:4

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  8. Content type: Research

    Lipopolysaccharide (LPS) from Helicobacter pylori (HP) plays an important role in gastric cancer occurrence and development. Toll-like receptor 4 (TLR4) and myeloid differential protein-2 (MD-2) are also reported...

    Authors: Nan Li, Huanbai Xu, Yurong Ou, Zhenzhong Feng, Qiong Zhang, Qing Zhu and Zhaogen Cai

    Citation: Diagnostic Pathology 2019 14:3

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  9. Content type: Research

    Pathological features of prostate cancer in Korean men were analyzed to determine whether identification of tumor volume, Gleason score (GS), focality, and location using radical prostatectomy (RP) specimens c...

    Authors: Young Hyo Choi, Ji Woong Yu, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee and Hwang Gyun Jeon

    Citation: Diagnostic Pathology 2019 14:2

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  10. Content type: Case Report

    Carcinomas composed predominantly or purely of malignant Paneth cells were rarely reported in gastrointestinal system. They have not been reported at gastroesophageal junction nor has the association with Barr...

    Authors: Wenyi Luo, Wayne L. Hofstetter and Dongfeng Tan

    Citation: Diagnostic Pathology 2019 14:1

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  11. Content type: Case Report

    Epignathus is a rare congenital orofacial teratoma infrequently associated with intracranial extension. Intracranial extension of an epignathus indicates a poor prognosis; however, only a small number of such ...

    Authors: Mari Kirishima, Sohsuke Yamada, Mitsuhisa Shinya, Shun Onishi, Yuko Goto, Ikumi Kitazono, Tsubasa Hiraki, Michiyo Higashi, Akira I. Hida and Akihide Tanimoto

    Citation: Diagnostic Pathology 2018 13:99

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  12. Content type: Research

    Alu repeats, belonging to the Short Interspersed Repetitive Elements (SINEs) class, contain about 25% of CpG sites in the human genome. Alu sequences lie in gene-rich regions, so their methylation is an import...

    Authors: Paola Orsini, Luciana Impera, Elisa Parciante, Cosimo Cumbo, Crescenzio F. Minervini, Angela Minervini, Antonella Zagaria, Luisa Anelli, Nicoletta Coccaro, Paola Casieri, Giuseppina Tota, Claudia Brunetti, Alessandra Ricco, Paola Carluccio, Giorgina Specchia and Francesco Albano

    Citation: Diagnostic Pathology 2018 13:98

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  13. Content type: Research

    Rapid transmission and high mortality of Ebola virus disease (EVD) highlight a urgent need of large scale, convenient and effective measure for Ebola virus screening. Application of monoclonal antibodies (mAbs...

    Authors: Junjie Zai, Kai Yi, Lilan Xie, Jiping Zhu, Xiaoting Feng and Yaoming Li

    Citation: Diagnostic Pathology 2018 13:96

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  14. Content type: Review

    Both Gram-Positive and Gram-Negative bacteria can secrete outer membrane vesicles (OMVs) in their growth and metabolism process. Originally, OMVs were considered as a by-product of bacterial merisis. However, ...

    Authors: Wei Cai, Dinesh Kumar Kesavan, Jie Wan, Mohamed Hamed Abdelaziz, Zhaoliang Su and Huaxi Xu

    Citation: Diagnostic Pathology 2018 13:95

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  15. Content type: Case Report

    Erdheim Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis characterized by widespread tissue infiltration by CD68-positive, CD1a-negative foamy histiocytes. ECD can be difficult to identify, a...

    Authors: Hany I. Sakr, Kaila Buckley, Robert Baiocchi, Weiqiang John Zhao and Jessica A. Hemminger

    Citation: Diagnostic Pathology 2018 13:94

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  16. Content type: Research

    Neoadjuvant chemotherapy (NACT) has been recently accepted as an effective alternative in patients with locally advanced cervical cancer. However, little is known about the effects of NACT on the immunological...

    Authors: Yun Liang, Weiguo Lü, Xiaofei Zhang and Bingjian Lü

    Citation: Diagnostic Pathology 2018 13:93

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  17. Content type: Case Report

    Extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT), is a rare aggressive subtype of non-Hodgkin lymphoma characterized by angioinvasion, angiodestruction, necrosis and strong association with Epstein-Barr v...

    Authors: Kyle Devins, Stephen J. Schuster, Gabriel C. Caponetti and Agata M. Bogusz

    Citation: Diagnostic Pathology 2018 13:92

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  18. Content type: Research

    Immunohistochemistry (IHC) for programmed cell death ligand 1 (PD-L1) displays staining diversity. We compared IHC staining of PD-L1 in gastric cancer (GC) by using three commercially available antibody clones...

    Authors: Jing Ma, Jianhui Li, Meirui Qian, Weili Han, Miaomiao Tian, Zengshan Li, Zhe Wang, Shuixiang He and Kaichun Wu

    Citation: Diagnostic Pathology 2018 13:91

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  19. Content type: Research

    In glomerular injury dendrin translocates from the slit diaphragm to the podocyte nucleus, inducing apoptosis. We analyzed dendrin expression in IgA glomerulonephritis and Henoch Schönlein purpura (IgAN/HSP) v...

    Authors: Maja Mizdrak, Katarina Vukojević, Natalija Filipović, Vesna Čapkun, Benjamin Benzon and Merica Glavina Durdov

    Citation: Diagnostic Pathology 2018 13:90

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  20. Content type: Research

    Colorectal sessile serrated adenoma/polyps (SSA/Ps) are considered early precursor lesions in the serrated neoplasia pathway. Recent studies have shown associations of SSA/Ps with lost MLH1 expression, a CpG i...

    Authors: Takashi Murakami, Yoichi Akazawa, Noboru Yatagai, Takafumi Hiromoto, Noriko Sasahara, Tsuyoshi Saito, Naoto Sakamoto, Akihito Nagahara and Takashi Yao

    Citation: Diagnostic Pathology 2018 13:88

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  21. Content type: Research

    Regulated in development and DNA damage response (REDD1), a gene responding to hypoxia or multiple DNA damage events, was recently implicated in cancer development and progression. Previously, in vivo and in vitr...

    Authors: Bin Chang, Jiao Meng, Huimin Zhu, Xiang Du, Lili Sun, Lei Wang, Shugang Li and Gong Yang

    Citation: Diagnostic Pathology 2018 13:87

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  22. Content type: Case Report

    Nephroblastoma (NB) is a malignant embryonal neoplasm derived from nephrogenic blastemal cells. NB usually forms a solid mass, but in extremely rare cases, it may show cystic changes.

    Authors: Nozomu Kurose, Michiho Takenaka, Manabu Yamashita, Chie Shimaguchi, Mariko Nakano, Bryant Britni, Xin Guo, Chizuru Futatsuya, Akihiro Shioya and Sohsuke Yamada

    Citation: Diagnostic Pathology 2018 13:84

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  23. Content type: Research

    Tissue heterogeneity in formalin-fixed paraffin-embedded (FFPE) breast cancer specimens may affect the accuracy of reverse transcription quantitative real-time PCR (RT-qPCR). Herein, we tested the impact of ti...

    Authors: Kerstin Hartmann, Kornelia Schlombs, Mark Laible, Claudia Gürtler, Marcus Schmidt, Ugur Sahin and Hans-Anton Lehr

    Citation: Diagnostic Pathology 2018 13:83

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  24. Content type: Case Report

    Indolent T-cell proliferative disorder of the GIT is a rare and provisional entity in the revised WHO 2016 classification. The patients usually have prolonged survival with persistent disease even without any ...

    Authors: Xingen Wang, Chi-Sing Ng, Cuimin Chen, Guangyin Yu and Weihua Yin

    Citation: Diagnostic Pathology 2018 13:82

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  25. Content type: Research

    Synovial sarcoma is a rare soft tissue tumor which contains the unique SS18-SSX1, SS18-SSX2 – or, rarely, SS18-SSX4 - fusion transcripts. It is well known that some soft tissue tumors, like Ewing sarcomas and ...

    Authors: Dóra Mihály, Noémi Nagy, Gergő Papp, Zsuzsanna Pápai and Zoltán Sápi

    Citation: Diagnostic Pathology 2018 13:81

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  26. Content type: Research

    Heat shock factor 1 (HSF1) was initially identified as a transcription factor encoding heat shock proteins, which assist in refolding or degrading damaged proteins. Recent studies have reported that HSF1 can a...

    Authors: Weigang Dai, Jinning Ye, Zhimei Zhang, Liang Yang, Hui Ren, Hui Wu, Jianhui Chen, Jieyi Ma, Ertao Zhai, Shirong Cai and Yulong He

    Citation: Diagnostic Pathology 2018 13:80

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  27. Content type: Research

    Anaplastic lymphoma kinase (ALK) is a key oncogenic driver in lung adenocarcinoma patients and its fusion proteins are routinely assessed. The microfluidic tissue processor (MTP) device is based on a chip-confine...

    Authors: Saška Brajkovic, Benjamin Pelz, Maria-Giuseppina Procopio, Anne-Laure Leblond, Grégoire Repond, Ariane Schaub-Clerigué, Diego G Dupouy and Alex Soltermann

    Citation: Diagnostic Pathology 2018 13:79

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  28. Content type: Case Report

    Transformation of follicular lymphoma most typically occurs as diffuse large B-cell lymphoma, however other forms of transformation such as classic Hodgkin lymphoma and lymphoblastic transformation can occur. ...

    Authors: Sarah M. Choi, Aleodor A. Andea, Min Wang, Amir Behdad, Lina Shao, Yanming Zhang, Xinyan Lu, David Dittmann, Juan Castro, Yi-Hua Chen and Juehua Gao

    Citation: Diagnostic Pathology 2018 13:78

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  29. Content type: Case Report

    RAF family activating fusions have been described as a potentially targetable molecular finding in a subset of soft tissue sarcomas. To further expand upon the landscape of this genetic feature, we describe a ...

    Authors: J. Kevin Hicks, Evita Henderson-Jackson, Julia Duggan, David M. Joyce and Andrew S. Brohl

    Citation: Diagnostic Pathology 2018 13:77

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  30. Content type: Research

    Automated image analysis enables quantitative measurement of steatosis in histological images. However, spatial heterogeneity of steatosis can make quantitative steatosis scores unreliable. To improve the reli...

    Authors: André Homeyer, Seddik Hammad, Lars Ole Schwen, Uta Dahmen, Henning Höfener, Yan Gao, Steven Dooley and Andrea Schenk

    Citation: Diagnostic Pathology 2018 13:76

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  31. Content type: Correction

    It has been highlighted that the original article [1] contained a typesetting mistake in the family name of Dominique Trudel.

    Authors: Andréanne Gagné, Bernard Têtu, Michèle Orain, Stéphane Turcotte, Marie Plante, Jean Grégoire, Marie-Claude Renaud, Isabelle Bairati and Dominique Trudel

    Citation: Diagnostic Pathology 2018 13:75

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    The original article was published in Diagnostic Pathology 2018 13:57

  32. Content type: Research

    Abnormally sustained immune reactions drive B-cell proliferation in some cases of marginal zone lymphoma but the CD4+ T-cell subsets, which are likely to contribute to the B-cell responses in the tumour microenvi...

    Authors: Katherine Wickenden, Nadia Nawaz, Sami Mamand, Deevia Kotecha, Amy L. Wilson, Simon D. Wagner and Matthew J. Ahearne

    Citation: Diagnostic Pathology 2018 13:74

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  33. Content type: Research

    Clear cell sarcoma of soft tissue (CCSST) and clear cell sarcoma-like gastrointestinal tumor (CCSLGT) are malignant mesenchymal tumors that share some pathological features, but they also have several differen...

    Authors: Keiko Segawa, Shintaro Sugita, Tomoyuki Aoyama, Terufumi Kubo, Hiroko Asanuma, Taro Sugawara, Yumika Ito, Mitsuhiro Tsujiwaki, Hiromi Fujita, Makoto Emori and Tadashi Hasegawa

    Citation: Diagnostic Pathology 2018 13:73

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  34. Content type: Research

    Hepatocellular carcinoma (HCC) is the second leading cause of cancer death in Asia; however, the molecular mechanism in its tumorigenesis remains unclear. Abnormal expression of claudins (CLDNs), a family of t...

    Authors: Lemeng Sun, Liangshu Feng and Jiuwei Cui

    Citation: Diagnostic Pathology 2018 13:72

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  35. Content type: Retraction Note

    This article [1] is retracted at request of the Editor. After publication of this article [1] concerns were raised regarding aspects of the methodology, including the choice of stains being inappropriate or in...

    Authors: Jian Tan, Jianpeng Hu, Yonghui He and Feilun Cui

    Citation: Diagnostic Pathology 2018 13:71

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    The original article was published in Diagnostic Pathology 2015 10:198

  36. Content type: Research

    Non-small cell lung cancer (NSCLC) and melanoma are frequent entities in routine diagnostics. Whereas the differential diagnosis is usually straight forward based on histomorphology, it can be challenging in p...

    Authors: Mark Kriegsmann, Katharina Kriegsmann, Alexander Harms, Rémi Longuespée, Christiane Zgorzelski, Jonas Leichsenring, Thomas Muley, Hauke Winter, Daniel Kazdal, Benjamin Goeppert and Arne Warth

    Citation: Diagnostic Pathology 2018 13:68

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  37. Content type: Research

    Conventional parameters including Ki67, hormone receptor and Her2/neu status are used for risk stratification for breast cancer. The serine protease urokinase plasminogen activator (uPA) and the plasminogen ac...

    Authors: Hans-Ullrich Völker, Michael Weigel, Annette Strehl and Lea Frey

    Citation: Diagnostic Pathology 2018 13:67

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  38. Content type: Research

    Triple-negative breast cancers (TNBCs) are a group of heterogeneous diseases with various morphology, prognosis, and treatment response. Therefore, it is important to identify valuable biomarkers to predict th...

    Authors: Miao Ruan, Tian Tian, Jia Rao, Xiaoli Xu, Baohua Yu, Wentao Yang and Ruohong Shui

    Citation: Diagnostic Pathology 2018 13:66

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  39. Content type: Case Report

    Pilomatricoma is a relatively common benign cutaneous adnexal neoplasm with differentiation towards the hair matrix, inner sheath of hair follicle and hair cortex. Proliferating pilomatricoma is a rare variant...

    Authors: Nozomu Kurose, Manabu Yamashita, Mariko Nakano, Xin Guo, Akihiro Shioya, Satoko Nakada, Hiroshi Minato and Sohsuke Yamada

    Citation: Diagnostic Pathology 2018 13:65

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  40. Content type: Research

    Tumor budding, meaning a detachment of tumor cells at the invasion front of colorectal carcinoma (CRC) into single cells or clusters (<=5 tumor cells), has been shown to correlate to an inferior clinical outco...

    Authors: Cleo-Aron Weis, Jakob Nikolas Kather, Susanne Melchers, Hanaa Al-ahmdi, Marion J. Pollheimer, Cord Langner and Timo Gaiser

    Citation: Diagnostic Pathology 2018 13:64

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  41. Content type: Research

    Breast cancer is by far the most frequent cancer among women. The proliferative index, Ki-67, is more and more taken into consideration for treatment decisions. However, the reliability of the established Ki-6...

    Authors: Essam Ayad, Ahmed Soliman, Shady Elia Anis, Amira Ben Salem, Pengchao Hu and Youhong Dong

    Citation: Diagnostic Pathology 2018 13:63

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  42. Content type: Case Report

    Breast carcinoma with osteoclast-like giant cells (OGCs) is infrequent, being most reported cased described as ductal invasive carcinomas. Invasive pleomorphic lobular carcinoma (PLC) is a distinct morphologic...

    Authors: Lourdes Peña-Jaimes, Irene González-García, María Eugenia Reguero-Callejas, Ignacio Pinilla-Pagnon, Belén Pérez-Mies, Víctor Albarrán-Artahona, Noelia Martínez-Jañez, Juan Manuel Rosa-Rosa and José Palacios

    Citation: Diagnostic Pathology 2018 13:62

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  43. Content type: Research

    Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy. Hypoxia-inducible factors, HIF-1α and HIF-2α, are expressed in the majority of ccRCC. Targeting immune checkpoints with the blockade...

    Authors: Hayriye Tatli Dogan, Merve Kiran, Burak Bilgin, Aydan Kiliçarslan, Mehmet Ali Nahit Sendur, Bülent Yalçin, Arslan Ardiçoglu, Ali Fuat Atmaca and Berrak Gumuskaya

    Citation: Diagnostic Pathology 2018 13:60

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