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  1. Content type: Research

    Small cell carcinoma of the uterine cervix is a rare and highly malignant tumor, and its etiopathogenesis is strongly related to high-risk HPV infections.

    Authors: Peifeng Li, Jing Ma, Xiumin Zhang, Yong Guo, Yixiong Liu, Xia Li, Danhui Zhao and Zhe Wang

    Citation: Diagnostic Pathology 2018 13:31

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  2. Content type: Research

    Telepathology (TP) provides remote pathology services for primary diagnosis practices, including intraoperative consultation of surgical pathology; it has not been widely implemented in China. In this study, t...

    Authors: Yingxin Huang, Yan Lei, Qi Wang, Dazhou Li, Lili Ma, Lili Guo, Minshan Tang, Guanglong Liu, Qianwen Yan, Lan Shen, Guihui Tong, Zhiliang Jing, Yan Zhang and Yongjian Deng

    Citation: Diagnostic Pathology 2018 13:29

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  3. Content type: Case Report

    Epithelioid cell histiocytoma (ECH), which is also known as epithelioid benign fibrous histiocytoma, has been classified as a rare variant of fibrous histiocytoma (FH). However, the recent detection of ALK pro...

    Authors: Ryuko Nakayama, Yuki Togashi, Satoko Baba, Yo Kaku, Yuki Teramoto, Takaki Sakurai, Hironori Haga and Kengo Takeuchi

    Citation: Diagnostic Pathology 2018 13:28

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  4. Content type: Case Report

    The diagnosis of granulomatous amoebic encephalitis is challenging for clinicians because it is a rare and lethal disease. Previous reports have indicated that Acanthamoeba with some specific genotypes tend to ca...

    Authors: Takahiro Matsui, Tetsuo Maeda, Shinsuke Kusakabe, Hideyuki Arita, Kenji Yagita, Eiichi Morii and Yuzuru Kanakura

    Citation: Diagnostic Pathology 2018 13:27

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  5. Content type: Retraction Note

    The editor has retracted this article [1] because it shows significant overlap with the following articles (amongst others) [2, 3]. None of the authors responded to correspondence regarding this retraction.

    Authors: Huifen Li, Weihua Huang and Rongcheng Luo

    Citation: Diagnostic Pathology 2018 13:26

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    The original article was published in Diagnostic Pathology 2015 10:117

  6. Content type: Research

    The translocation t(14;18)(q32;q21) is the genetic hallmark of follicular lymphoma (FL) and can be observed in 85–90% of cases. Whether the translocation is restricted to cells with germinal center B-cell phen...

    Authors: Perikles Kosmidis, Barbara Mankel, Falko Fend and Patrick Adam

    Citation: Diagnostic Pathology 2018 13:25

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  7. Content type: Case Report

    Although p53 signature, benign-appearing epithelial cells with p53 diffuse expression, is frequently found in the fallopian tubes, the clinical and pathological significance of this lesion in the case of high-...

    Authors: Yuichiro Hatano, Shinya Fukuda, Hiroshi Makino, Hiroyuki Tomita, Ken-ichirou Morishige and Akira Hara

    Citation: Diagnostic Pathology 2018 13:24

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  8. Content type: Research

    Hepatic steatosis renders hepatocytes vulnerable to injury, resulting in the progression of preexisting liver disease. Previous animal and cell culture studies implicated mammalian target of rapamycin (mTOR), ...

    Authors: Euno Choi, Won Kim, Sae Kyung Joo, Sunyoung Park, Jeong Hwan Park, Yun Kyung Kang, So-Young Jin and Mee Soo Chang

    Citation: Diagnostic Pathology 2018 13:23

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  9. Content type: Research

    The G protein-coupled bile acid receptor (TGR5) is a cell surface receptor which induces the production of intracellular cAMP and promotes epithelial-mesenchymal transition in gastric cancer cell lines. TGR5 i...

    Authors: Chaohui Lisa Zhao, Ali Amin, Yiang Hui, Dongfang Yang and Weibiao Cao

    Citation: Diagnostic Pathology 2018 13:22

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  10. Content type: Research

    Tumour budding (TB) and Tumour Stroma Ratio (TSR) may be rewarding in the treatment stratification of patients with stage II colon cancer. However, lack of standardization may exclude these parameters from bei...

    Authors: Ann C. Eriksen, Johnnie B. Andersen, Jan Lindebjerg, René dePont Christensen, Torben F. Hansen, Sanne Kjær-Frifeldt and Flemming B. Sørensen

    Citation: Diagnostic Pathology 2018 13:20

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  11. Content type: Research

    Detection of HER2/neu receptor overexpression and/or amplification is a prerequisite for efficient anti-HER2 treatment of breast and gastric carcinomas. Immunohistochemistry (IHC) of the HER2 protein is the mo...

    Authors: Andreas H. Scheel, Frédérique Penault-Llorca, Wedad Hanna, Gustavo Baretton, Peter Middel, Judith Burchhardt, Manfred Hofmann, Bharat Jasani and Josef Rüschoff

    Citation: Diagnostic Pathology 2018 13:19

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  12. Content type: Case Report

    Ischemic fasciitis is a distinctive pseudosarcomatous entity with a marked predilection for elderly and physically debilitated or immobilized patients. The etiology of these lesions is unknown but felt to be r...

    Authors: Taha Sachak, Nyla A. Heerema, Joel Mayerson, Jason E. Payne, Anil Parwani and O. Hans Iwenofu

    Citation: Diagnostic Pathology 2018 13:18

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  13. Content type: Research

    The clinicopathological features and Epstein-Barr virus (EBV) infection status of lymphoma in children and adolescents in South China is under-researched. South China is a well-known high-incidence area of EBV...

    Authors: Changfei Qin, Yuhua Huang, Yanfen Feng, Min Li, Na Guo and Huilan Rao

    Citation: Diagnostic Pathology 2018 13:17

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  14. Content type: Case Report

    Plasma cell myeloma (PCM) is a neoplasm of terminally differentiated B lymphocytes with molecular heterogeneity. Although therapy-related myeloid neoplasms are common in plasma cell myeloma patients after chem...

    Authors: Jonathon H. Gralewski, Ginell R. Post, Frits van Rhee and Youzhong Yuan

    Citation: Diagnostic Pathology 2018 13:15

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  15. Content type: Case Report

    Mast cell leukemia (MCL) is a very rare form of systemic mastocytosis (SM) and accounts for less than 0.5% of all mastocytosis. The diagnosis of MCL requires the presence of SM criteria, accompanied by leukemi...

    Authors: Yalin Zheng, Lin Nong, Li Liang, Wei Wang and Ting Li

    Citation: Diagnostic Pathology 2018 13:14

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  16. Content type: Research

    The DecisionDx-Melanoma test provides prognostic information for patients with cutaneous melanoma (CM). Using formalin-fixed paraffin-embedded primary tumor tissue, the RT-PCR-based test classifies patients in...

    Authors: Robert W. Cook, Brooke Middlebrook, Jeff Wilkinson, Kyle R. Covington, Kristen Oelschlager, Federico A. Monzon and John F. Stone

    Citation: Diagnostic Pathology 2018 13:13

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  17. Content type: Review

    The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer ty...

    Authors: Margarita Udall, Maria Rizzo, Juliet Kenny, Jim Doherty, SueAnn Dahm, Paul Robbins and Eric Faulkner

    Citation: Diagnostic Pathology 2018 13:12

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  18. Content type: Research

    Several studies have suggested that claudin proteins, which are the main components of tight junction structures, are related to the regulation of cell polarity and cell differentiation.

    Authors: Xiaowei Zhang, Haiming Wang, Qian Li, Yunpeng Liu, Peiqing Zhao and Tao Li

    Citation: Diagnostic Pathology 2018 13:11

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    The Retraction Note to this article has been published in Diagnostic Pathology 2018 13:40

  19. Content type: Case Report

    Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare malignancy, recently recognized as a provisional entity by the World Health Organization. Although increasing data have been publis...

    Authors: Ricardo Garcia Pastorello, Felipe D’Almeida Costa, Cynthia A. B. T. Osório, Fabiana B. A. Makdissi, Stephania Martins Bezerra, Marina de Brot, Antonio Hugo J. F. M. Campos, Fernando Augusto Soares and José Vassallo

    Citation: Diagnostic Pathology 2018 13:10

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  20. Content type: Research

    Nephroblastoma or Wilms tumor is the most frequent kidney cancer in children and accounts for 98% of kidney tumors in this age group. Despite favorable prognosis, a subgroup of these patients progresses to rec...

    Authors: Ana Paula Percicote, Gabriel Lazaretti Mardegan, Elizabeth Schneider Gugelmim, Sergio Ossamu Ioshii, Ana Paula Kuczynski, Seigo Nagashima and Lúcia de Noronha

    Citation: Diagnostic Pathology 2018 13:9

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  21. Content type: Research

    Human intestinal spirochetosis (IS) has been recognized for decades, but whether it represents commensalism or a pathogenic process remains controversial. IS is diagnosed on routine stains with confirmation by...

    Authors: Rondell P. Graham, Bita V. Naini, Sejal S. Shah, Christina A. Arnold, Rajesh Kannangai, Michael S. Torbenson and Dora M. Lam-Himlin

    Citation: Diagnostic Pathology 2018 13:7

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  22. Content type: Case Report

    IgG4-related disease often forms a mass and the affected lesion is clinically removed because the mass cannot be differentiated from a neoplasm. Affected lesions commonly occur in the pancreas, hepatobiliary t...

    Authors: Atsuko Masunaga, Fumihiro Ishibashi, Eitetsu Koh, Takashi Oide, Yasuo Sekine and Kenzo Hiroshima

    Citation: Diagnostic Pathology 2018 13:6

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  23. Content type: Research

    Programmed death ligand 1 (PD-L1) has shown potential as a therapeutic target in numerous solid tumors. Its prognostic significance has also been established in pancreatic ductal adenocarcinoma (PDAC). The pre...

    Authors: Xiaolong Liang, Jian Sun, Huanwen Wu, Yufeng Luo, Lili Wang, Junliang Lu, Zhiwen Zhang, Junchao Guo, Zhiyong Liang and Tonghua Liu

    Citation: Diagnostic Pathology 2018 13:5

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  24. Content type: Research

    Identification of predictive molecular alterations in lung adenocarcinoma is essential for accurate therapeutic decisions. Although several molecular approaches are available, a number of issues, including tum...

    Authors: Eleonora Bonaparte, Chiara Pesenti, Laura Fontana, Rossella Falcone, Leda Paganini, Anna Marzorati, Stefano Ferrero, Mario Nosotti, Paolo Mendogni, Claudia Bareggi, Silvia Maria Sirchia, Silvia Tabano, Silvano Bosari and Monica Miozzo

    Citation: Diagnostic Pathology 2018 13:4

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  25. Content type: Research

    Extra-mammary Paget’s disease of the vulva (EMPDV) is an infrequent chronic disease that often recurs. The aim of the study was to assess the presence of neoangiogenesis and the expression of epithelial-mesenc...

    Authors: Lara Alessandrini, Nicolò Clemente, Tiziana Perin, Giorgio Giorda, Vincenzo Canzonieri and Francesco Sopracordevole

    Citation: Diagnostic Pathology 2018 13:2

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  26. Content type: Case Report

    A proper balance between the activator and the repressor form of GLI3, a zinc-finger transcription factor downstream of hedgehog signaling, is essential for proper development of various organs during developm...

    Authors: Saki Ito, Riko Kitazawa, Ryuma Haraguchi, Takeshi Kondo, Ayaka Ouchi, Yasuo Ueda and Sohei Kitazawa

    Citation: Diagnostic Pathology 2018 13:1

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  27. Content type: Research

    The nucleolus is an organelle that is an ultrastructural element of the cell nucleus observed in H&E staining as a roundish body stained with eosin due to its high protein content. Changes in the nucleoli cyto...

    Authors: Piotr Donizy, Przemyslaw Biecek, Agnieszka Halon, Adam Maciejczyk and Rafal Matkowski

    Citation: Diagnostic Pathology 2017 12:88

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  28. Content type: Research

    Mounting evidence has shown that KRAS and BRAF are somatic mutations associated with low grade serous carcinoma (LGSC) of the ovary. However, the frequency of KRAS or BRAF mutation was variable in literatures,...

    Authors: Yan Xu, Rui Bi, Yaoxing Xiao, Xiaoyu Tu, Ming Li, Anqi Li, Ling Shan, Shuling Zhou and Wentao Yang

    Citation: Diagnostic Pathology 2017 12:87

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  29. Content type: Case Report

    Renal transplant recipients have increased risk for developing malignant diseases because of immunosuppression or donor-to-recipient transmission. Malignant rhabdoid tumor (MRT) is a rare, highly aggressive an...

    Authors: Jing Xiong, Tiefen Su, Pengcheng Zhu, Qilin Ao, Qiurong Ruan and Guoping Wang

    Citation: Diagnostic Pathology 2017 12:86

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  30. Content type: Case Report

    Although adenocarcinomas showing neuroendocrine differentiation or those mixed with high-grade neuroendocrine carcinoma (NEC) are sometimes encountered, composite tumors comprising neuroendocrine tumor (NET) G...

    Authors: Hiromi Kanno-Okada, Tomoko Mitsuhashi, Katsuhiro Mabe, Tadakazu Shimoda and Yoshihiro Matsuno

    Citation: Diagnostic Pathology 2017 12:85

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  31. Content type: Research

    Hematoxylin-eosin (HE) staining of a full-thickness rectal wall fragment is classically used for the diagnosis of Hirschsprung disease (HD). However, this technique requires large fragments for a better diagno...

    Authors: Suellen Serafini, Maria Mercês Santos, Ana Cristina Aoun Tannuri, Maria Claudia Nogueira Zerbini, Maria Cecília de Mendonça Coelho, Josiane de Oliveira Gonçalves and Uenis Tannuri

    Citation: Diagnostic Pathology 2017 12:84

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  32. Content type: Case Report

    Plasmablastic lymphoma (PBL) is relatively new clinical entity described as a distinct subtype of diffuse large B-cell lymphoma (DLBCL). It is characterized by its aggressive nature and proliferation of large ...

    Authors: Ita Hadžisejdić, Emina Babarović, Luka Vranić, Antica Duletić Načinović, Ksenija Lučin, Maja Krašević and Nives Jonjić

    Citation: Diagnostic Pathology 2017 12:83

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  33. Content type: Case Report

    KIAA1549-BRAF fusion is the most common genetic event in pilocytic astrocytoma (PA), and leads to activation of the mitogen activated protein kinase (MAPK) signaling pathway. Fusions o...

    Authors: Jeffrey Helgager, Hart G. Lidov, Navin R. Mahadevan, Mark W. Kieran, Keith L. Ligon and Sanda Alexandrescu

    Citation: Diagnostic Pathology 2017 12:82

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  34. Content type: Case Report

    TP53 mutations are rarely identified in low grade endometrioid carcinoma of the endometrium, and their pathogenic significance in such tumors is evidenced by the fact that TP53 aberrat...

    Authors: Oluwole Fadare and Vinita Parkash

    Citation: Diagnostic Pathology 2017 12:81

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  35. Content type: Research

    Steatosis is routinely assessed histologically in clinical practice and research. Automated image analysis can reduce the effort of quantifying steatosis. Since reproducibility is essential for practical use, ...

    Authors: André Homeyer, Patrik Nasr, Christiane Engel, Stergios Kechagias, Peter Lundberg, Mattias Ekstedt, Henning Kost, Nick Weiss, Tim Palmer, Horst Karl Hahn, Darren Treanor and Claes Lundström

    Citation: Diagnostic Pathology 2017 12:80

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  36. Content type: Case Report

    Maffucci syndrome is a congenital, non-hereditary mesodermal dysplasia characterized by multiple enchondromas and hemangiomas. The presence of visceral vascular lesions in this syndrome is exceedingly rare.

    Authors: Xiao-Dan Huang, Hao-Sen Jiao, Zheng Yang, Chuang-Qi Chen, Yu-Long He and Xin-Hua Zhang

    Citation: Diagnostic Pathology 2017 12:79

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  37. Content type: Research

    Composite intestinal adenoma-microcarcinoid (CIAM) is a rare colorectal lesion that mostly comprises a conventional adenomatous component with a minute proportion of neuroendocrine (NE) component. Although mic...

    Authors: Mi-Jung Kim, Eun-Jung Lee, Do Sun Kim, Doo Han Lee, Eui Gon Youk and Hyun-Jung Kim

    Citation: Diagnostic Pathology 2017 12:78

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  38. Content type: Case Report

    A small number of rhabdomyosarcoma (RMS) cases involve the bone marrow. A leukemic presentation of RMS has been reported in a few case series, although almost all cases of leukemic RMS are not completely mimic...

    Authors: Osamu Imataki, Makiko Uemura, Shumpei Uchida, Shigeyuki Yokokura, Akihiro Takeuchi, Ryo Ishikawa, Akihiro Kondo, Kayoko Seo and Norimitsu Kadowaki

    Citation: Diagnostic Pathology 2017 12:77

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  39. Content type: Case Report

    Renal cell carcinoma most commonly metastasizes to the lungs, skeleton or liver. Metastatic renal cell carcinoma to the breast is very rare, especially for clear cell carcinoma, and few cases regarding this co...

    Authors: Yanjun Xu, Rui Hou, Qijie Lu, Yifan Deng and Bin Hu

    Citation: Diagnostic Pathology 2017 12:76

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  40. Content type: Case Report

    Spontaneous isolated dissection of the superior mesenteric artery (SMA) can lead to bowel ischemia, aneurysm rupture, or even death. Studies have suggested that mechanical or hemodynamic stress on the vascular...

    Authors: Nobuhiro Akuzawa, Makoto Kurabayashi, Tsukasa Suzuki, Daisuke Yoshinari, Mitsunobu Kobayashi, Yoshifumi Tanahashi, Fujio Makita and Ryusei Saito

    Citation: Diagnostic Pathology 2017 12:74

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  41. Content type: Case Report

    Dieulafoy’s lesion, also known as a caliber-persistent artery, is a shallow, small, and rare lesion that occurs along the lesser curvature of proximal stomach. It is rare for a Dieulafoy’s lesion to present as...

    Authors: Hsi-Lan Huang, Chi Yan Leung and Chien-Jui Cheng

    Citation: Diagnostic Pathology 2017 12:73

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  42. Content type: Research

    Immune checkpoint blockade targeting PD-1/PD-L1 has shown efficacy in several types of cancers. However, the correlation between PD-L1/PD-1 expression and the specific clinicopathological features in papillary...

    Authors: Yanhua Bai, Dongfeng Niu, Xiaozheng Huang, Ling Jia, Qiang Kang, Fangyuan Dou, Xinqiang Ji, Weicheng Xue, Yiqiang Liu, Zhongwu Li, Qin Feng, Dongmei Lin and Kennichi Kakudo

    Citation: Diagnostic Pathology 2017 12:72

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  43. Content type: Case Report

    Hyalinizing clear cell carcinoma (HCCC) is a rare low-grade tumour of salivary glands that was first described as a distinct entity in 1994 by Milchgrub et al. EWSR1-ATF1 fusion was found to be specific for this ...

    Authors: Batool M. AlAli, Mohammed J. Alyousef, Ahmad Salah Kamel, Mohammad A. Al hamad, Mohammad H. Al-Bar and Roaa M. Algowiez

    Citation: Diagnostic Pathology 2017 12:70

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  44. Content type: Case Report

    Inflammatory myofibroblastic tumor (IMT) of the stomach is extremely rare in adults and exhibits a variable biological behavior that ranges from frequently benign lesions to more aggressive variants. Here we r...

    Authors: Jun Fan, Bo Huang, Xiuping Yang, Ming Yang, Jun He and Xiu Nie

    Citation: Diagnostic Pathology 2017 12:68

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