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  1. Content type: Case Report

    KIAA1549-BRAF fusion is the most common genetic event in pilocytic astrocytoma (PA), and leads to activation of the mitogen activated protein kinase (MAPK) signaling pathway. Fusions o...

    Authors: Jeffrey Helgager, Hart G. Lidov, Navin R. Mahadevan, Mark W. Kieran, Keith L. Ligon and Sanda Alexandrescu

    Citation: Diagnostic Pathology 2017 12:82

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  2. Content type: Case Report

    TP53 mutations are rarely identified in low grade endometrioid carcinoma of the endometrium, and their pathogenic significance in such tumors is evidenced by the fact that TP53 aberrat...

    Authors: Oluwole Fadare and Vinita Parkash

    Citation: Diagnostic Pathology 2017 12:81

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  3. Content type: Research

    Steatosis is routinely assessed histologically in clinical practice and research. Automated image analysis can reduce the effort of quantifying steatosis. Since reproducibility is essential for practical use, ...

    Authors: André Homeyer, Patrik Nasr, Christiane Engel, Stergios Kechagias, Peter Lundberg, Mattias Ekstedt, Henning Kost, Nick Weiss, Tim Palmer, Horst Karl Hahn, Darren Treanor and Claes Lundström

    Citation: Diagnostic Pathology 2017 12:80

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  4. Content type: Case Report

    Maffucci syndrome is a congenital, non-hereditary mesodermal dysplasia characterized by multiple enchondromas and hemangiomas. The presence of visceral vascular lesions in this syndrome is exceedingly rare.

    Authors: Xiao-Dan Huang, Hao-Sen Jiao, Zheng Yang, Chuang-Qi Chen, Yu-Long He and Xin-Hua Zhang

    Citation: Diagnostic Pathology 2017 12:79

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  5. Content type: Research

    Composite intestinal adenoma-microcarcinoid (CIAM) is a rare colorectal lesion that mostly comprises a conventional adenomatous component with a minute proportion of neuroendocrine (NE) component. Although mic...

    Authors: Mi-Jung Kim, Eun-Jung Lee, Do Sun Kim, Doo Han Lee, Eui Gon Youk and Hyun-Jung Kim

    Citation: Diagnostic Pathology 2017 12:78

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  6. Content type: Case Report

    Renal cell carcinoma most commonly metastasizes to the lungs, skeleton or liver. Metastatic renal cell carcinoma to the breast is very rare, especially for clear cell carcinoma, and few cases regarding this co...

    Authors: Yanjun Xu, Rui Hou, Qijie Lu, Yifan Deng and Bin Hu

    Citation: Diagnostic Pathology 2017 12:76

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  7. Content type: Case Report

    A small number of rhabdomyosarcoma (RMS) cases involve the bone marrow. A leukemic presentation of RMS has been reported in a few case series, although almost all cases of leukemic RMS are not completely mimic...

    Authors: Osamu Imataki, Makiko Uemura, Shumpei Uchida, Shigeyuki Yokokura, Akihiro Takeuchi, Ryo Ishikawa, Akihiro Kondo, Kayoko Seo and Norimitsu Kadowaki

    Citation: Diagnostic Pathology 2017 12:77

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  8. Content type: Case Report

    Spontaneous isolated dissection of the superior mesenteric artery (SMA) can lead to bowel ischemia, aneurysm rupture, or even death. Studies have suggested that mechanical or hemodynamic stress on the vascular...

    Authors: Nobuhiro Akuzawa, Makoto Kurabayashi, Tsukasa Suzuki, Daisuke Yoshinari, Mitsunobu Kobayashi, Yoshifumi Tanahashi, Fujio Makita and Ryusei Saito

    Citation: Diagnostic Pathology 2017 12:74

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  9. Content type: Case Report

    Dieulafoy’s lesion, also known as a caliber-persistent artery, is a shallow, small, and rare lesion that occurs along the lesser curvature of proximal stomach. It is rare for a Dieulafoy’s lesion to present as...

    Authors: Hsi-Lan Huang, Chi Yan Leung and Chien-Jui Cheng

    Citation: Diagnostic Pathology 2017 12:73

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  10. Content type: Research

    Immune checkpoint blockade targeting PD-1/PD-L1 has shown efficacy in several types of cancers. However, the correlation between PD-L1/PD-1 expression and the specific clinicopathological features in papillary...

    Authors: Yanhua Bai, Dongfeng Niu, Xiaozheng Huang, Ling Jia, Qiang Kang, Fangyuan Dou, Xinqiang Ji, Weicheng Xue, Yiqiang Liu, Zhongwu Li, Qin Feng, Dongmei Lin and Kennichi Kakudo

    Citation: Diagnostic Pathology 2017 12:72

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  11. Content type: Case Report

    Hyalinizing clear cell carcinoma (HCCC) is a rare low-grade tumour of salivary glands that was first described as a distinct entity in 1994 by Milchgrub et al. EWSR1-ATF1 fusion was found to be specific for this ...

    Authors: Batool M. AlAli, Mohammed J. Alyousef, Ahmad Salah Kamel, Mohammad A. Al hamad, Mohammad H. Al-Bar and Roaa M. Algowiez

    Citation: Diagnostic Pathology 2017 12:70

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  12. Content type: Research

    Immune cell infiltrates (ICI) of tumors are scored by pathologists around tumor glands. To obtain a better understanding of the immune infiltrate, individual immune cell types, their activation states and loca...

    Authors: Zhaoxuan Ma, Stephen L. Shiao, Emi J. Yoshida, Steven Swartwood, Fangjin Huang, Michael E. Doche, Alice P. Chung, Beatrice S. Knudsen and Arkadiusz Gertych

    Citation: Diagnostic Pathology 2017 12:69

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  13. Content type: Case Report

    Inflammatory myofibroblastic tumor (IMT) of the stomach is extremely rare in adults and exhibits a variable biological behavior that ranges from frequently benign lesions to more aggressive variants. Here we r...

    Authors: Jun Fan, Bo Huang, Xiuping Yang, Ming Yang, Jun He and Xiu Nie

    Citation: Diagnostic Pathology 2017 12:68

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  14. Content type: Methodology

    Precise prognostic and predictive variables allowing improved post-operative treatment stratification are missing in patients treated for stage II colon cancer (CC). Investigation of tumor infiltrating lymphoc...

    Authors: Ann C. Eriksen, Johnnie B. Andersen, Martin Kristensson, René dePont Christensen, Torben F. Hansen, Sanne Kjær-Frifeldt and Flemming B. Sørensen

    Citation: Diagnostic Pathology 2017 12:65

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  15. Content type: Research

    Immunohistochemical staining with conventional anti-β-catenin antibody has been applied as a diagnostic tool for desmoid-type fibromatosis (DF). This study aimed to evaluate the diagnostic and prognostic value...

    Authors: Tomohisa Sakai, Yoshihiro Nishida, Shunsuke Hamada, Hiroshi Koike, Kunihiro Ikuta, Takehiro Ota and Naoki Ishiguro

    Citation: Diagnostic Pathology 2017 12:66

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  16. Content type: Case Report

    Mesonephric adenocarcinoma (MA) is a rare tumor believed to arise from mesonephric remnants occurring mostly in the uterine cervix and, to a lesser extent, the corpus. Since the first case report of MA in the ...

    Authors: Hiroka Ando, Yuko Watanabe, Minori Ogawa, Hiromi Tamura, Tomomi Deguchi, Kayo Ikeda, Mayumi Fujitani, Mitsunori Shioji, Tomoko Tsujie, Reiko Doi, Akinori Wakimoto and Shiro Adachi

    Citation: Diagnostic Pathology 2017 12:63

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  17. Content type: Case Report

    Intravascular large B-cell lymphoma (IVLBCL) is a subtype of diffuse large B-cell lymphoma (DLBCL) that is rare and highly aggressive and that may progressively involve many organs. CNS (central nervous system...

    Authors: Bo Luo, Jia-mei Chen, Jie Liu, Wen-he Li, Yu-xiang Shi, Pan Zeng, Yong-hui Xie and Hong-feng Zhang

    Citation: Diagnostic Pathology 2017 12:64

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  18. Content type: Research

    Ciliated muconodular papillary tumors (CMPTs) are newly recognized rare peripheral lung nodules that are histologically characterized by ciliated columnar, goblet, and basal cells. Although recent studies have...

    Authors: Emiko Udo, Bungo Furusato, Kazuko Sakai, Leah M Prentice, Tomonori Tanaka, Yuka Kitamura, Tomoshi Tsuchiya, Naoya Yamasaki, Takeshi Nagayasu, Kazuto Nishio and Junya Fukuoka

    Citation: Diagnostic Pathology 2017 12:62

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  19. Content type: Case Report

    Abernethy malformation is a rare congenital anomaly characterised by the partial or complete absence of the portal vein and the subsequent development of an extrahepatic portosystemic shunt. Caroli’s disease i...

    Authors: Xiao-xiao Mi, Xiao-guang Li, Zi-rong Wang, Ling Lin, Chun-hai Xu and Jun-ping Shi

    Citation: Diagnostic Pathology 2017 12:61

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  20. Content type: Review

    Pleural angiosarcoma is a rare tumor that causes diffuse pleural thickening and effusion, mimicking mesothelioma. Immunohistochemistry is needed to highlight endothelial differentiation. We describe the first ...

    Authors: Daniela Cabibi, Giulia Pipitone, Rossana Porcasi, Sabrina Ingrao, Ignazio Benza, Calogero Porrello, Massimo Cajozzo and Antonino Giulio Giannone

    Citation: Diagnostic Pathology 2017 12:60

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  21. Content type: Research

    A 15-gene expression profile test has been clinically validated and is widely utilized in newly diagnosed uveal melanoma (UM) patients to assess metastatic potential of the tumor. As most patients are treated ...

    Authors: Kristen M. Plasseraud, Jeff K. Wilkinson, Kristen M. Oelschlager, Trisha M. Poteet, Robert W. Cook, John F. Stone and Federico A. Monzon

    Citation: Diagnostic Pathology 2017 12:59

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  22. Content type: Case Report

    Gangliocytic paraganglioma (GP) is a rare neuroendocrine neoplasm, which occurs mostly in the periampullary portion of the duodenum; the majority of the reported cases of duodenal GP has been of benign nature ...

    Authors: Keisuke Nonaka, Yoko Matsuda, Akira Okaniwa, Atsuko Kasajima, Hironobu Sasano and Tomio Arai

    Citation: Diagnostic Pathology 2017 12:57

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  23. Content type: Research

    Advancing knowledge in molecular pathogenesis of hepatocellular carcinoma (HCC) opens up new horizons in the diagnostic, prognostic and therapeutic perspectives. Assessing the expression of molecular targets p...

    Authors: Regina Cheuk-lam Lo, Carmen Oi-ning Leung, Kenneth Siu-ho Chok and Irene Oi-lin Ng

    Citation: Diagnostic Pathology 2017 12:56

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  24. Content type: Methodology

    Fusion genes generated from chromosomal translocation play an important role in hematological malignancies. Detection of fusion genes currently employ use of either conventional RT-PCR methods or fluorescent i...

    Authors: Xiaodong Lyu, Xianwei Wang, Lina Zhang, Zhenzhu Chen, Yu Zhao, Jieying Hu, Ruihua Fan and Yongping Song

    Citation: Diagnostic Pathology 2017 12:55

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  25. Content type: Research

    Histologic grade is the most important predictor of the clinical outcome of non-muscle invasive (Ta, T1) papillary urothelial carcinoma (NMIPUCa), but its ambiguous criteria diminish its power to predict recur...

    Authors: Ji Eun Kwon, Nam Hoon Cho, Yeong-Jin Choi, So Dug Lim, Yong Mee Cho, Sun Young Jun, Sanghui Park, Young A. Kim, Sung-Sun Kim, Mi Sun Choe, Jung-dong Lee, Dae Yong Kang, Jae Y. Ro and Hyun-Jung Kim

    Citation: Diagnostic Pathology 2017 12:54

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  26. Content type: Case Report

    Invasive pleomorphic lobular carcinoma (PLC) is an aggressive subtype of invasive lobular carcinoma of the breast, which has its own histopathological and biological features. The metastatic patterns for PLC a...

    Authors: Xiangjie Sun, Ke Zuo, Dan Huang, Baohua Yu, Yufan Cheng and Wentao Yang

    Citation: Diagnostic Pathology 2017 12:52

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  27. Content type: Research

    GATA-binding protein 3 (GATA3) has been identified as a sensitive marker for breast carcinoma but its sensitivity in primary genital extramammary Paget diseases (EMPDs) has not been well studied.

    Authors: Ming Zhao, Lixin Zhou, Li Sun, Yan Song, Yunquan Guo, Xun Zhang, Feng Zhao, Peng Wang, Junqiu Yue, Dongfeng Niu, Zhongwu Li, Xiaozheng Huang, Qiang Kang, Lin Jia, Jinping Lai and Dengfeng Cao

    Citation: Diagnostic Pathology 2017 12:51

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  28. Content type: Case Report

    Solitary fibrous tumor is an uncommon soft tissue neoplasm with intermediate biological behavior, which rarely metastasizes. Malignant solitary fibrous tumor, although not clearly defined, is rarely described ...

    Authors: Andrea Ronchi, Elvira La Mantia, Vincenzo Gigantino, Sisto Perdonà, Marco De Sio, Gaetano Facchini, Renato Franco and Annarosaria De Chiara

    Citation: Diagnostic Pathology 2017 12:50

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  29. Content type: Research

    Nerve growth factor (NGF) is a neurotrophic factor which regulates cell development and proliferation. Recently, it has been suggested that NGF induces heme oxygenase-1 (HO1) expression, and that both NGF and ...

    Authors: Sang Jae Noh, Kyoung Min Kim and Kyu Yun Jang

    Citation: Diagnostic Pathology 2017 12:48

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  30. Content type: Research

    The dimerization efficiency of FGFR3 transmembrane domain plays a critical role in the formation of a normal skeleton through the negative regulation of bone development. Recently, gain-of-function mutations i...

    Authors: Muhammad Ajmal, Asif Mir, Muhammad Shoaib, Salman Akbar Malik and Muhammad Nasir

    Citation: Diagnostic Pathology 2017 12:47

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  31. Content type: Case Report

    Aggressive natural killer cell leukemia/lymphoma (ANKL) is a rare and highly aggressive NK cell neoplasm with a short clinical course and poor prognosis and is often misdiagnosed and confused with NK/T cell ly...

    Authors: Xiaoke Jin, Youhai Xu, Jun Zhang, Guangxi Li, Dongping Huang, Yuqiong Yang and Hesheng He

    Citation: Diagnostic Pathology 2017 12:46

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  32. Content type: Research

    To support a hypothesis that there is an intrinsic interplay between coronary artery disease (CAD) and type 2 diabetes (T2D), we used RNA-seq to identify unique gene expression signatures of CAD, T2D, and coex...

    Authors: Rui Gong, Menghui Chen, Cuizhao Zhang, Manli Chen and Haibin Li

    Citation: Diagnostic Pathology 2017 12:44

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  33. Content type: Research

    Among the many challenges in cancer diagnosis is the early distinction between metastatic cancer and a secondary tumor. This difficulty stems from the lack of markers that offer high sensitivity and specificit...

    Authors: Patrícia Chaves de Freitas Campos Jucá, Stephany Corrêa, Giselle Maria Vignal, Maria Theresa de Souza Accioly, Suzana Angélica Silva Lustosa, Eliana Abdelhay and Delcio Matos

    Citation: Diagnostic Pathology 2017 12:43

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  34. Content type: Research

    Adaptor proteins bridge the gap between cell surface receptors and their downstream signaling elements. The clinicopathological and prognostic values of adaptor proteins remain poorly understood. The purpose o...

    Authors: Lili Wang, Junliang Lu, Huanwen Wu, Li Wang, Xiaolong Liang, Zhiyong Liang and Tonghua Liu

    Citation: Diagnostic Pathology 2017 12:42

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  35. Content type: Research

    HER2 assessment in biopsy specimens of gastric cancer (GC) is challenging because of the intratumoral heterogeneity. False negative results may be get because of limited biopsy material. The aim of this study ...

    Authors: Chen Xu, Yalan Liu, Xiaowen Ge, Dongxian Jiang, Ying Zhang, Yuan Ji, Jun Hou, Jie Huang, Jieakesu Su, Haiying Zeng, Jing Qin and Yingyong Hou

    Citation: Diagnostic Pathology 2017 12:41

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  36. Content type: Case Report

    Intestinal differentiation of primary mucinous adenocarcinoma of the uterine corpus is exceedingly rare in comparison to the approximately 25% rate in endocervical and ovarian mucinous carcinoma. Additionally,...

    Authors: Mafalda Trippel, Sara Imboden, Andrea Papadia, Michael D. Mueller, Nando Mertineit, Kirsi Härmä, Alina Nicolae, Erik Vassella and Tilman T. Rau

    Citation: Diagnostic Pathology 2017 12:39

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  37. Content type: Case Report

    Metastatic pulmonary calcification (MPC) is rarely reported in primary hyperparathyroidism, especially MPC develops quickly. We report such a case here with a literature review.

    Authors: Hui-ming Sun, Fei Chen, Hong-lin Yin, Xiao-yong Xu, Hong-bing Liu and Bei-lei Zhao

    Citation: Diagnostic Pathology 2017 12:38

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  38. Content type: Case Report

    Ewing’s sarcoma (ES) and primitive neuroectodermal tumors (PNET) are closely related tumors. Although soft tissue ES/PNET are common in clinical practice, they are rare in the small intestine. Because of the a...

    Authors: Teng Li, Fang Zhang, Yarui Cao, Shoubin Ning, Yongmin Bi, Weicheng Xue and Li Ren

    Citation: Diagnostic Pathology 2017 12:37

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  39. Content type: Case Report

    Endometrial stromal sarcomas arising in extrauterine and extraovarian sites, in the absence of a primary uterine lesion are quite rare, especially in the absence of endometriosis. They usually present as an ab...

    Authors: Lara Alessandrini, Francesco Sopracordevole, Giulio Bertola, Simona Scalone, Martina Urbani, Gianmaria Miolo, Tiziana Perin, Fabrizio Italia and Vincenzo Canzonieri

    Citation: Diagnostic Pathology 2017 12:36

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  40. Content type: Case Report

    Extranodal follicular dendritic cell sarcoma (FDCS) is a very rare malignancy with a variable clinical course. It is often not considered and has the potential to result in a misdiagnosis of other common sarco...

    Authors: Guang-Jie Duan, You-Li Wu, Hui Sun, Lang Lang, Zhi-Wen Chen and Xiao-Chu Yan

    Citation: Diagnostic Pathology 2017 12:35

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  41. Content type: Case Report

    Pituitary carcinoma is a rare entity requiring the presence of metastasis to confirm its malignant potential. We report a case of pituitary carcinoma and discuss the diagnosis and management of this lesion in ...

    Authors: Amy S. Joehlin-Price, Douglas A. Hardesty, Christina A. Arnold, Lawrence S. Kirschner, Daniel M. Prevedello and Norman L. Lehman

    Citation: Diagnostic Pathology 2017 12:34

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  42. Content type: Research

    Pituitary adenoma (PA) is a benign primary tumor that arises from the pituitary gland and is associated with ophthalmological, neurological and endocrinological abnormalities. However, causes that increase tum...

    Authors: Paulina Vaitkiene, Indre Valiulyte, Brigita Glebauskiene and Rasa Liutkeviciene

    Citation: Diagnostic Pathology 2017 12:33

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