Articles

Clinicopathologic significance of TRAP1 expression in colorectal cancer: a large scale study of human colorectal adenocarcinoma tissues

Colorectal cancer is the major cause of cancer mortality, despite development of therapeutic strategies. The novel marker tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial heat sho...

Authors: Min Gyoung Pak, Hyong Jong Koh and Mee Sook Roh

A transcriptome profile in hepatocellular carcinomas based on integrated analysis of microarray studies

Despite new treatment options for hepatocellular carcinomas (HCC) recently, 5-year survival remains poor, ranging from 50 to 70%, which may attribute to the lack of early diagnostic biomarkers. Thus, developin...

Authors: Feifei Wang, Ruliang Wang, Qiuwen Li, Xueling Qu, Yixin Hao, Jingwen Yang, Huixia Zhao, Qian Wang, Guanghui Li, Fengyun Zhang, He Zhang, Xuan Zhou, Xioumei Peng, Yang Bian and Wenhua Xiao

Primary mediastinal clear cell sarcoma: a case report and review of the literature

Clear cell sarcoma (CCS) is a rare malignant soft-tissue neoplasm that displays melanocytic markers and exhibits striking histopathological features. The tumour has a predilection for the lower extremities and...

Authors: Long Jin, Yuxia Sui, Haili Zhu, Zhizhong Chen and Shuguang Liu

Double-hit lymphomas: clinical, morphological, immunohistochemical and cytogenetic study in a series of Brazilian patients with high-grade non-Hodgkin lymphoma

Double-hit lymphomas (DHL) are rare high-grade neoplasms characterized by two translocations: one involving the gene MYC and another involving genes BCL2 or BCL6, whose diagnosis depends on cytogenetic examinatio...

Authors: Cristiano Claudino Oliveira, Helena Maciel-Guerra, Luan Kucko, Eric Jun Hirama, Américo Delgado Brilhante, Francisco Carlos Quevedo, Isabela Werneck da Cunha, Fernando Augusto Soares, Ligia Niero-Melo, Patrícia Pintor dos Reis and Maria Aparecida Custodio Domingues

Increased expression of Cks1 protein is associated with lymph node metastasis and poor prognosis in nasopharyngeal carcinoma

The Cks1 protein is an essential factor in regulating cell cycle by mediating the ubiquitination of CDK inhibitor p27^kip1. It has been reported that aberrant expression of Cks1 and p27^kip1 proteins was found in v...

Authors: Lina Xu, Songqing Fan, Jin Zhao, Peng Zhou, Shuzhou Chu, Jiadi Luo, Qiuyuan Wen, Lingjiao Chen, Sailan Wen, Li Wang and Lei Shi

Case report: maternal mosaicism resulting in inheritance of a novel GATA6 mutation causing pancreatic agenesis and neonatal diabetes mellitus

Haploinsufficiency of the GATA6 transcription factor gene was recently found to be the most common cause of pancreatic agenesis, a rare cause of neonatal diabetes mellitus. Although most cases are de novo, we des...

Authors: Daphne Yau, Elisa De Franco, Sarah E. Flanagan, Sian Ellard, Miriam Blumenkrantz and John J. Mitchell

Marginal zone lymphoma-derived interfollicular diffuse large B-cell lymphoma harboring 20q12 chromosomal deletion and missense mutation of BIRC3 gene: a case report

Diffuse large B-cell lymphoma (DLBCL) typically leads to effacement of the nodal architecture by an infiltrate of malignant cells. Rarely (<1%), DLBCL can present with an interfollicular pattern (DLBCL-IF) pre...

Authors: Joseph Hatem, April M. Schrank-Hacker, Christopher D. Watt, Jennifer J. D. Morrissette, Adam I. Rubin, Ellen J. Kim, Sunita D. Nasta, Mariusz A. Wasik and Agata M. Bogusz

Analysis of epithelial-mesenchymal transition markers in the histogenesis of hepatic progenitor cell in HBV-related liver diseases

The origin and heterogeneity of hepatic progenitor cells (HPCs) remain unclear. This study aimed to investigate the involvement of epithelial-mesenchymal transition (EMT) in the histogenesis of HPCs.

Authors: Wei Xu, Nong-Rong Wang, Hua-Feng Wang, Qiong Feng, Jun Deng, Zhi-Qiang Gong, Jian Sun, Xiao-Liang Lou, Xue-Feng Yu, Lv Zhou, Jin-Ping Hu, Xiao-Feng Huang, Xiao-Qing Qi, Yan-Juan Deng, Rui Gong, Yan Guo…

Plasma microRNAs are associated with acute exacerbation in idiopathic pulmonary fibrosis

Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) has high short-term mortality with unknown causes. To predict this malignant condition in clinics is challenging. In this study, we aim to demonstra...

Authors: Haiyan Min, Shanshan Fan, Shiyu Song, Yi Zhuang, Hui Li, Yongzheng Wu, Hourong Cai, Long Yi, Jinghong Dai and Qian Gao

Maxillary calcifying epithelial odontogenic tumor with sinus and buccal vestibule extension: a case report and immunohistochemical study

Calcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasia, locally aggressive, that tends to invade bone and adjacent soft tissues. This case report describes the thirteenth known case of CEOT ...

Authors: Cristina Munteanu, Daniel Pirici, Alex Emilian Stepan, Adrian Camen and Claudiu Margaritescu

Next-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report

Inhibition of the oncogenic fusion-gene EML4-ALK is a current first-line approach for patients with stage IV non-small cell lung cancer. While FISH was established as the gold standard for identifying these pa...

Authors: Anna-Lena Volckmar, Volker Endris, Farastuk Bozorgmehr, Clemens Lier, Carlota Porcel, Martina Kirchner, Jonas Leichsenring, Roland Penzel, Michael Thomas, Peter Schirmacher, Arne Warth and Albrecht Stenzinger

Prognostic significance of mucin expression profiles in breast carcinoma with signet ring cells: a clinicopathological study

Signet ring cells (SRCs) often accompany gastrointestinal carcinoma, referred to as SRC carcinoma; however, breast cancers containing SRCs have not been well characterized, leaving the prognostic significance ...

Authors: Ryuji Ohashi, Ayako Hayama, Keiko Yanagihara, Koji Yamashita, Takashi Sakatani, Hiroyuki Takei and Zenya Naito

Intraosseous inflammatory myofibroblastic tumor of the mandible with a novel ATIC-ALK fusion mutation: a case report

Inflammatory myofibroblastic tumor (IMT) is a rare low-grade malignant neoplasm with a predilection for children and young adults, and typically arises in the lung, abdominopelvic region, and retroperitoneum. ...

Authors: Yoko Tateishi, Koji Okudela, Shigeo Kawai, Takehisa Suzuki, Shigeaki Umeda, Mai Matsumura, Mitomu Kioi and Kenichi Ohashi

Metachronous serous endometrial intraepithelial carcinoma and serous peritoneal carcinoma: analysis of probable independent lesions

Uterine serous endometrial intraepithelial carcinoma (SEIC) is an immediate precursor of invasive carcinoma. The majority of stage IA SEICs are curable, but those with latent peritoneal metastasis and/or capil...

Authors: Mitsuko Furuya, Teiko Sato, Reiko Tanaka, Masafumi Yamamoto, Naho Ruiz Yokota and Etsuko Miyagi

Potential molecular characteristics in situ in response to repetitive UVB irradiation

To identify molecular characteristics in situ in response to repetitive UVB (ultraviolet-B) irradiation.

Authors: Wenqi Chen and Jinhai Zhang

The clinicopathological significance of angiogenesis in hindgut neuroendocrine tumors obtained via an endoscopic procedure

As the World Health Organization grading system for gastroenteropancreatic-neuroendocrine tumors (GEP-NETs) may not always correlate with tumor progression, it is imperative that other independent predictors o...

Authors: Yoichiro Okubo, Osamu Motohashi, Norisuke Nakayama, Ken Nishimura, Rika Kasajima, Yohei Miyagi, Manabu Shiozawa, Emi Yoshioka, Masaki Suzuki, Kota Washimi, Kae Kawachi, Madoka Nito, Yoichi Kameda and Tomoyuki Yokose

Retraction Note: Ulnar malignant peripheral nerve sheath tumour diagnosis in a mixed-breed dog as a model to study human: histologic, immunohistochemical, and clinicopathologic study

Authors: Abbas Tavasoly, Javad Javanbakht, Fariba Khaki, Ehsan Hosseini, Alimohammad Bahrami, Mehdi Aghamohammad Hassan and Mohammadmehdi Mirabad

Retraction note: Investigations of renal function using the level of neutrophil gelatinase-associated lipocalin associated with single-dose of cisplatin during chemotherapy

Authors: Omid Maghsoudi, Seyed Hesamoddin Mirjalili, Mojtaba Dolatabadi, Mostafa Fallah Joshaghani, Mojtaba Zarea, Emad Yahaghi and Aram Mokarizadeh

Retraction note: Serotonin 5-HT⁷ receptor agonist, LP-211, exacerbates Na⁺, K⁺-ATPase/Mg2⁺ ATPase imbalances in spinal cord-injured male rats

Authors: Abbas Norouzi-Javidan, Javad Javanbakht, Fardin Barati, Nahid Fakhraei, Fatemeh Mohammadi and Ahmad Reza Dehpour

Retraction note: Anti-inflammatory and protective investigations on the effects of Theranekron® “an alcoholic extract of the Tarantula cubensis” on wound healing of peritoneal in the rat: an in vivo comparative study

Authors: Farajollah Adib-Hashemi, Farshad Farahmand, Shamim Fattah Hesari, Bijan Rezakhaniha, Ehsan Fallah, Amir Farshid Fayyaz and Masoomeh Dadpay

Retraction note: Effect of platelet-rich plasma on the healing of cutaneous defects exposed to acute to chronic wounds: a clinico-histopathologic study in rabbits

Authors: Omid Ostvar, Sahar Shadvar, Emad Yahaghi, Kamran Azma, Amir Farshid Fayyaz, Koorosh Ahmadi and Iradj Nowrouzian

Retraction note: Neuropathological microscopic features of abortions induced by Bunyavirus/or Flavivirus infections

Authors: Javad Javanbakht, Seyed Hossein Mardjanmehr, Abbas Tavasoly and Mohammad Hossein Nazemshirazi

Retraction Note: Down-regulated microRNA-124 expression as predictive biomarker and its prognostic significance with clinicopathological features in breast cancer patients

Authors: Ali Arabkheradmand, Aghdas Safari, Mehri Seifoleslami, Emad Yahaghi and Masoumeh Gity

Retraction Note: Detection of Helicobacter spp. DNA in the colonic biopsies of stray dogs: molecular and histopathological investigations

Authors: Fatemeh Soghra Abdi, Shahram Jamshidi, Farhad Moosakhani and Farhang Sasani

Retraction note: Up-regulation of miR-130b expression level and down-regulation of miR-218 serve as potential biomarker in the early detection of human osteosarcoma

Authors: Afshin Taheriazam, Amir Jouya Talaei, Mohammad Jamshidi, Mohammadreza Shakeri, Samaneh Khoshbakht, Emad Yahaghi and Marjan Shokrani

Retraction note: Cyto-histopathological and outcome features of the prepuce squamous cell carcinoma of a mixed breed dog

Authors: Javad Yaghoobi Yeganeh Manesh, Radmehr Shafiee, Ali Mohammad Bahrami, Mehdi Pourzaer, Maryam Pourzaer, Behnam Pedram, Javad Javanbakht, Aram Mokarizadeh and Farshid Khadivar

Retraction note: A histopathological analysis of the epidemiology of coronary atherosclerosis: an autopsy study

Authors: Negin Abedinzadeh, Behnam Pedram, Yasan Sadeghian, Seyed Mohamad Hossein Tabatabaei Nodushan, Maryam Gilasgar, Mahsa Darvish and Aram Mokarizadeh

Retraction note: Down-regulated MicroRNA 148b expression as predictive biomarker and its prognostic significance associated with clinicopathological features in non-small-cell lung cancer patients

Authors: Naeemeh Ghasemkhani, Sahar Shadvar, Yasamin Masoudi, Amir Jouya Talaei, Emad Yahaghi, Peyman Karimi Goudarzi and Ebrahim Shakiba

Retraction Note: Comparative value of clinical, cytological, and histopathological features in feline mammary gland tumors; an experimental model for the study of human breast cancer

Authors: Radmehr Shafiee, Javad Javanbakht, Nahid Atyabi, Alimohammad Bahrami, Danial Kheradmand, Reyhaneh Safaei, Farshid Khadivar and Ehsan Hosseini

Retraction note: Cervical type AB thymoma (mixed) tumour diagnosis in a mynah as a model to study human: clinicohistological, immunohistochemical and cytohistopathological study

Authors: Fariba Khaki, Javad Javanbakht, Farhang Sasani, Mohammad Javad Gharagozlou, Alimohammad Bahrami, Hemmat Moslemzadeh and Reza Sheikhzadeh

Retraction note: Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: an experimental study with histopathological evaluation

Authors: Samad Alimohammadi, Rahim Hobbenaghi, Javad Javanbakht, Danial Kheradmand, Reza Mortezaee, Maryam Tavakoli, Farshid Khadivar and Hamid Akbari

Retraction note: Down-regulation of microRNA-26a and up-regulation of microRNA-27a contributes to aggressive progression of human osteosarcoma

Authors: Afshin Taheriazam, Reza Bahador, Seyyed Hasan Karbasy, Seyed Mir Mansoor Moazen Jamshidi, Ali Torkaman, Emad Yahaghi and Mohammadreza Shakeri

Retraction note: Cutaneous mast cell tumor (Mastocytoma): cyto-histopathological and haematological investigations

Authors: Ehsan Hosseini, Behnam Pedram, Ali Mohammad Bahrami, Mohammad Hossein Jaberi Moghaddam, Javad Javanbakht, Fatemeh Emami Ghomi, Najme Jaberi Moghaddam, Mobin Koohestani and Radmehr Shafiee

Retraction Note: High doses of garlic extract significantly attenuated the ratio of serum LDL to HDL level in rat-fed with hypercholesterolemia diet

Authors: Tahereh Ebrahimi, Behnoosh Behdad, Maryam Agha Abbasi, Rahman Ghaffarzadegan Rabati, Amir Farshid Fayyaz, Vahid Behnod and Ali Asgari

Retraction Note: Clinicopathologic characterization of visceral gout of various internal organs – a study of 2 cases from a venom and toxin research center

Authors: Alireza Nasoori, Behnam Pedram, Zahra Kamyabi-Moghaddam, Aram Mokarizadeh, Hamid Pirasteh, Amir Farshid Fayyaz and Mohammad Barat Shooshtari

Retraction note: Decrease expression and clinicopathological significance of miR-148a with poor survival in hepatocellular carcinoma tissues

Authors: Hossein Ajdarkosh, Masoomeh Dadpay, Emad Yahaghi, Elham Rostami Pirzaman, Amir Farshid Fayyaz, Ebrahim Khodaverdi Darian and Aram Mokarizadeh

Retraction Note: Neuropathological and neuroprotective features of vitamin B₁₂ on the dorsal spinal ganglion of rats after the experimental crush of sciatic nerve: an experimental study

Authors: Rahim Hobbenaghi, Javad Javanbakht, Ehan Hosseini, Shahin Mohammadi, Mojtaba Rajabian, Pedram Moayeri and Mehdi Aghamohammad Hassan

Retraction note: Histopathological features of bone regeneration in a canine segmental ulnar defect model

Authors: Rahim Hobbenaghi, Pariya Mahboob, Siamak Saifzadeh, Javad Javanbakht, Javad Yaghoobi Yeganeh Manesh, Rasool Mortezaee, Seyed Rashid Touni, Ehsan Hosseini, Shahin Aghajanshakeri, Milad Moloudizargari and Soheil Javaherypour

Retraction note: Histopathological and clinical evaluation of Kombucha tea and Nitrofurazone on cutaneous full-thickness wounds healing in rats: an experimental study

Authors: Fardin Barati, Javad Javanbakht, Farajollah Adib-Hashemi, Ehsan Hosseini, Reyhaneh Safaeie, Mojtaba Rajabian, Mostafa Razmjoo, Reza Sedaghat and Mehdi Aghamohammad Hassan

The findings of CT and MRI in patients with metanephric adenoma

Metanephric adenoma (MA) is a benign renal tumor that is difficult to distinguish from a malignant tumor via traditional radiography. The diagnosis of MA is often dependent on postsurgical histopathological ex...

Authors: Jing Yan, Jing-Liang Cheng, Chen-Fei Li, Yan-Bang Lian, Yuan Zheng, Xue-Ping Zhang and Chao-Yan Wang

Quality of sweat test (ST) based on the proportion of sweat sodium (Na) and sweat chloride (Cl) as diagnostic parameter of cystic fibrosis: are we on the right way?

To assess the quality of sweat test (ST) based on the proportion of sweat sodium and sweat chloride as diagnostic parameter of cystic fibrosis (CF).

Authors: Alethéa Guimarães Faria, Fernando Augusto Lima Marson, Carla Cristina de Souza Gomez, Maria Ângela Gonçalves de Oliveira Ribeiro, Lucas Brioschi Morais, Maria de Fátima Servidoni, Carmen Sílvia Bertuzzo, Eulália Sakano, Maura Goto, Ilma Aparecida Paschoal, Mônica Corso Pereira, Gabriel Hessel, Carlos Emílio Levy, Adyléia Aparecida Dalbo Contrera Toro, Andressa Oliveira Peixoto, Maria Cristina Ribeiro Simões…

Systematic assessment of HER2/neu in gynecologic neoplasms, an institutional experience

HER2/neu overexpression and/or amplification has been widely studied in a number of solid tumors, primarily in the breast. In gynecologic neoplasms, determination of HER2/neu status has not been well studied as a...

Authors: Jennifer S. Woo, Sophia K. Apple, Peggy S. Sullivan, Jian-Yu Rao, Nora Ostrzega and Neda A. Moatamed

Rapid growth of mitotically active cellular fibroma of the ovary: a case report and review of the literature

Mitotically active cellular fibroma (MACF) of the ovary, characterized by relatively high mitotic activity without severe atypia, represents a relatively new disease entity. MACF is categorized as a benign ova...

Authors: Katsuya Matsuda, Seiko Tateishi, Yuko Akazawa, Akira Kinoshita, Shiko Yoshida, Sachiko Morisaki, Ai Fukushima, Takahiro Matsuwaki, Koh-Ichiro Yoshiura and Masahiro Nakashima

Clinicopathological features and BRAF^V600E mutations in patients with isolated hypothalamic-pituitary Langerhans cell histiocytosis

Isolated hypothalamic-pituitary Langerhans cell histiocytosis (HPLCH) is very rare. We investigated the clinicopathological characteristics, endocrine function changes, BRAF^V600E mutations and treatments of isola...

Authors: Zhen Huo, Tao Lu, Zhiyong Liang, Fan Ping, Jie Shen, Jingjing Lu, Wenbing Ma, Dachun Zhao and Dingrong Zhong

Primary alveolar rhabdomyosarcoma of the bone: two cases and review of the literature

Rhabdomyosarcoma (RMS) is a malignant tumor of mesenchymal origin and comprises the largest category of soft-tissue sarcomas both in children and adolescents. From a pediatric oncology point of view, RMS has t...

Authors: Petra Balogh, Rita Bánusz, Monika Csóka, Zsófia Váradi, Edit Varga and Zoltán Sápi

An Xp11.2 translocation renal cell carcinoma with SMARCB1 (INI1) inactivation in adult end-stage renal disease: a case report

Xp11.2 translocation/transcription factor E3 (TFE3) rearrangement renal cell carcinoma (RCC) is a rare subtype of RCC with limited clinical and pathological data.

Authors: Lu Yu, Jun Li, Sanpeng Xu, Mariajose Navia Miranda, Guoping Wang and Yaqi Duan

Retraction Note: Paediatric Ewing-like sarcoma arising from the cranium – a unique diagnostic challenge

Authors: Ian J. Robertson, Fadel Bennani, Ronan S. Ryan, Waqar Khan and M. Kevin Barry

TP53 gene mutation analysis in chronic lymphocytic leukemia by nanopore MinION sequencing

The assessment of TP53 mutational status is becoming a routine clinical practice for chronic lymphocytic leukemia patients (CLL). A broad spectrum of molecular techniques has been employed so far, including both ...

Authors: Crescenzio Francesco Minervini, Cosimo Cumbo, Paola Orsini, Claudia Brunetti, Luisa Anelli, Antonella Zagaria, Angela Minervini, Paola Casieri, Nicoletta Coccaro, Giuseppina Tota, Luciana Impera, Annamaria Giordano, Giorgina Specchia and Francesco Albano

Development of a programmed cell death ligand-1 immunohistochemical assay validated for analysis of non-small cell lung cancer and head and neck squamous cell carcinoma

A high-quality programmed cell-death ligand 1 (PD-L1) diagnostic assay may help predict which patients are more likely to respond to anti-programmed cell death-1 (PD-1)/PD-L1 antibody-based cancer therapy. Her...

Authors: Marlon C. Rebelatto, Anita Midha, Amita Mistry, Constantine Sabalos, Nicole Schechter, Xia Li, Xiaoping Jin, Keith E. Steele, Paul B. Robbins, John A. Blake-Haskins and Jill Walker

Severe active C3 glomerulonephritis triggered by immune complexes and inactivated after eculizumab therapy

Understanding the role of alternative complement pathway dysregulation in membranoproliferative glomerulonephritis (MPGN) has led to a dramatic shift in its classification into two subgroups: immune complex-me...

Authors: Tanja Kersnik Levart, Dušan Ferluga, Alenka Vizjak, Jerica Mraz and Nika Kojc