Articles

ALK expressed in a gastrointestinal stromal tumor harboring PDGFRA p. D842V mutation:a case report

Gastrointestinal stromal tumors (GISTs) are the most common type of adult mesenchymal neoplasms. The events that drive GIST oncogenesis are primarily KIT or PDGFRA mutations, which lead to the susceptibility of t...

Authors: Jun Fan, Ming Yang, Bo Huang, Zhenkao Wang, Danju Luo, Jiwei Zhang, Peng Zhang, Heshui Shi, Yan Li and Xiu Nie

Cutaneous pilomatrical carcinosarcoma: a case report with molecular analysis and literature review

Cutaneous pilomatrical carcinosarcoma (CS) is a very rare biphasic tumor composed of admixed epithelial and mesenchymal malignant cells, with limited information on its pathogenesis. We report a case of piloma...

Authors: Thi My Hanh Luong, Yuko Akazawa, Zhanna Mussazhanova, Katsuya Matsuda, Nozomi Ueki, Shiro Miura, Toshihide Hara, Hiroko Yokoyama and Masahiro Nakashima

Targeted literature review on use of tumor mutational burden status and programmed cell death ligand 1 expression to predict outcomes of checkpoint inhibitor treatment

To achieve optimal outcomes, an individual approach is needed in the treatment and care of patients. The potential value of tumor mutational burden (TMB) status and/or programmed cell death ligand 1 (PD-L1) ex...

Authors: Tina Krieger, Isobel Pearson, Judith Bell, Jim Doherty and Paul Robbins

Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report

Precision medicine based on genomic analysis of germline or tumor tissue is attracting attention. However, there is no consensus on how to apply the results of genomic analysis to treatment.

Authors: Hiroshi Hongo, Takeo Kosaka, Eriko Aimono, Hiroshi Nishihara and Mototsugu Oya

Uterine intravenous leiomyomatosis with an isolated large metastasis to the right atrium: a case report

An intravenous leiomyomatosis is a special type of uterine leiomyoma characterized by the formation of benign leiomyomatous tissue within the vascular wall. Although histologically benign, intracardiac metasta...

Authors: Mitsutake Yano, Tomomi Katoh, Yoshie Nakajima, Shiro Iwanaga, Rei Kin, Eito Kozawa and Masanori Yasuda

Myoepithelioma-like tumor of the vulvar region: a case report in China and review of the literature

Myoepithelioma-like tumor of the vulvar region (MELTVR) is a recently described mesenchymal neoplasm which typically arising in vulvar regions of adult women.

Authors: Yan Xu, Hui Gao and Jin-Li Gao

Orbital involvement by NUT midline carcinoma: new presentation and encouraging outcome managed by radiotherapy combined with tyrosine kinase inhibitor: a case report

NUT midline carcinoma (NMC) is a poorly differentiated squamous cancer with a median survival at less than 7 months. NMC is resistant to conventional chemotherapies and characterized by rearrangement of the NUT g...

Authors: Peiwei Chai, Chuandi Zhou, Renbing Jia and Yefei Wang

Causes of misdiagnoses by thyroid fine-needle aspiration cytology (FNAC): our experience and a systematic review

FNA is a simple, safe, cost-effective and accurate diagnostic tool for the initial screening of patients with thyroid nodules. The aims of this study were to determine the diagnostic utility of FNAC performed ...

Authors: Yanli Zhu, Yuntao Song, Guohui Xu, Zhihui Fan and Wenhao Ren

Next generation diagnostic pathology: use of digital pathology and artificial intelligence tools to augment a pathological diagnosis

Authors: Anil V. Parwani

Primary epithelioid rhabdomyosarcoma of the stomach: a case report and review of literature

Epithelioid rhabdomyosarcoma is a rare tumor that generally occurs in the bladder, the parotid gland, or the skin of the neck. We describe an unusual case of primary epithelioid rhabdomyosarcoma of the stomach...

Authors: Yangkun Wang, Pei Guo, Zhishang Zhang, Runde Jiang and Zuguo Li

MicroRNA-937 is overexpressed and predicts poor prognosis in patients with colon cancer

Colon cancer is a heterogeneous tumor and a leading cause of cancer-related mortality. MicroRNA (miRNA) has been proposed as the biomarker in cancers. The aim of this study was to investigate the clinical sign...

Authors: Huiya Liu, Lin Ma, Ling Wang and Yizuo Yang

Splenic cord capillary hemangioma with non-islet cell tumor hypoglycemia: a case report

Splenic cord capillary hemangioma is a rare benign vascular lesion classified as a splenic hamartoma. On the other hand, non-islet cell tumor hypoglycemia (NICTH) is one of the rare causes of spontaneous hypog...

Authors: Tatsuaki Daimon, Takeo Kosaka, Minoru Horinaga, Junichi Saito, Yoshito Ueyama, Shoji Matsuzaki and Mototsugu Oya

Protein tyrosine phosphatase PTPN1 modulates cell growth and associates with poor outcome in human neuroblastoma

Protein tyrosine phosphatases (PTPs) regulate neuronal differentiation and survival, but their expression patterns and functions in human neuroblastoma (NB) are scarcely known. Here, we have investigated the f...

Authors: Caroline E. Nunes-Xavier, Olaia Aurtenetxe, Laura Zaldumbide, Ricardo López-Almaraz, Asier Erramuzpe, Jesús M. Cortés, José I. López and Rafael Pulido

Comparative pathologic analysis of mediastinal B-cell lymphomas: selective expression of p63 but no GATA3 optimally differentiates primary mediastinal large B-cell lymphoma from classic Hodgkin lymphoma

Interpretation of mediastinal biopsy is often challenging even for experienced pathologists especially when a hematolymphoid neoplasm is suspected. Primary mediastinal large B-cell lymphoma (PMLBCL) and classi...

Authors: Hyun-Jung Kim, Hee Kyung Kim, Gyeongsin Park, Soo Kee Min, Hee Jeong Cha, Hyekyung Lee, Suk Jin Choi, Hee Young Na, Ji-Young Choe and Ji Eun Kim

MicroRNA-1298 is downregulated in non-small cell lung cancer and suppresses tumor progression in tumor cells

MicroRNAs (miRNAs) have been reported to serve pivotal roles in tumorigenesis. This study sough to assess the expression and clinical significance of microRNA-1298 (miR-1298) in patients with non-small cell lu...

Authors: Zhonghai Du, Jun Wu, Juan Wang, Yan Liang, Sensen Zhang, Zhimei Shang and Wenchao Zuo

Concordance between sequential transbronchial lung cryobiopsy and surgical lung biopsy in patients with diffuse interstitial lung disease

Increasing evidence indicates the utility of transbronchial lung cryobiopsy (TBLC) for the diagnosis of interstitial lung disease (ILD). However, only one study has compared TBLC and surgical lung biopsy (SLB)...

Authors: Yoshiaki Zaizen, Yasuo Kohashi, Kishio Kuroda, Kazuhiro Tabata, Yuka Kitamura, Akira Hebisawa, Yuji Saito and Junya Fukuoka

Chest wall lymph node metastasis from follicular thyroid carcinoma: a rare case report

Distant metastases from follicular thyroid carcinoma are mainly hematogenous and are commonly observed in the lungs and bones. Other rare sites are the parotid gland, skin, brain, ovary, adrenal gland, kidney,...

Authors: Taolang Li, Zhiyuan Ma, Chengli Lu, Quanzhong Zhou, Zelong Feng, Xinglong Wu, Yi Luo, Dan Li, Xiaoming Cheng and Xuemei Liu

Uterine lesions with sex cord-like architectures: a systematic review

Sex cord-like elements are rarely observed in uterine lesions, but these morphological patterns could appear in a variety of uterine tumors and non-tumorous lesions. In this review, we collected the literature...

Authors: Meng Jia, Ping-Li Sun and Hongwen Gao

Expression of P63 and its correlation with prognosis in diffuse large B-cell lymphoma: a single center experience

Large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma among adults. In some cases, DLBCL may seem similar to carcinoma cells, presenting a round, oval, or polygonal shape and clear nu...

Authors: Wan-Ming Hu, Jie-Tian Jin, Chen-Yan Wu, Jia-Bin Lu, Li-Hong Zhang, Jing Zeng and Su-Xia Lin

Signet ring cell variant of follicular thyroid carcinoma: Report of two cases with focus on morphological, expressional and genetic characteristics

Follicular thyroid carcinoma (FTC) is a neoplasm that presents with a micro-follicular growth pattern and a neutrally stained cytoplasm. Seldom, FTCs display unusual morphological characteristics – but given t...

Authors: Martin Hysek, Kenbugul Jatta, Adam Stenman, Eva Darai-Ramqvist, Jan Zedenius, Anders Höög and C. Christofer Juhlin

Vulvar myeloid sarcoma as the presenting symptom of acute myeloid leukemia: a case report and literature review of Chinese patients, 1999–2018

Myeloid sarcoma (MS), which represents a rare malignancy that comprises of myeloid blasts occurring at extra-medullary sites, closely correlates with the onset and relapse of acute myeloid leukemia (AML) and o...

Authors: Xilin Zhang, Peichen Huang, Zhuo Chen, Xinling Bi, Ying Wang and Jianhua Wu

Vulvar Paget disease secondary to high-grade urothelial carcinoma with underlying massive vascular embolization and cervical involvement: case report of unusual presentation

Vulvar extramammary Paget disease is a rare chronic condition, that presents with non-specific symptoms such as pruritus and eczematous lesions. Because most of these lesions are noninvasive, the distinction b...

Authors: Walquiria Quida Salles Pereira Primo, Guttenberg Rodrigues Pereira Primo, Dunya Bachour Basilio, Karime Kalil Machado, Jesus Paula Carvalho and Filomena M. Carvalho

The role of p-Stat3 Y705 immunohistochemistry in glioblastoma prognosis

In spite of the multimodal treatment used today, glioblastoma is still the most aggressive and lethal cerebral tumour. To increase survival in these patients, novel therapeutic targets must be discovered. Sign...

Authors: Sergiu Susman, Radu Pîrlog, Daniel Leucuța, Andrei Otto Mitre, Vlad Adrian Padurean, Carmen Melincovici, Ioana Moldovan, Doinița Crișan and Stefan Ioan Florian

Clinical, genetic, and molecular characterization of hyperphosphatasia with mental retardation: a case report and literature review

Hyperphosphatasia with mental retardation syndrome (HPMRS) is a recessive disorder characterized by high blood levels of alkaline phosphatase together with typical dysmorphic signs such as cleft palate, intell...

Authors: Layal Abi Farraj, Wassim Daoud Khatoun, Naji Abou Chebel, Victor Wakim, Katia Dawali and Michella Ghassibe-Sabbagh

A unique uterine cervical “teratocarcinosarcoma”: a case report

Teratocarcinosarcoma (TCS) is a rare aggressive tumor of the nasal cavity and paranasal sinuses and has both epithelial and two or more mesenchymal components. In other organs, 5 cases of ovarian tumors closel...

Authors: Kozue Ito, Mitsutake Yano, Aiko Ogasawara, Maiko Miwa, Eito Kozawa and Masanori Yasuda

MicroRNA 3113-5p is a novel marker for early cardiac ischemia/reperfusion injury

Ischemia/reperfusion (I/R) injury of heart is one of the major causes of acute cardiac injury, which may result in worsening or even loss of heart function. With novel microRNAs being evolutionarily discovered...

Authors: Yuanyuan Chen, Xing Ye and Fengping Yan

PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance

Protein arginine methyltransferase-1 (PRMT1) is associated with the progression of various tumor types and the process of epithelial to mesenchymal transition (EMT). However, the expression of PRMT1 in renal c...

Authors: Jelena Filipović, Martina Bosić, Sanja Ćirović, Maja Životić, Duško Dunđerović, Dejan Đorđević, Snežana Živković-Perišić, Aleksandar Lipkovski and Jasmina Marković-Lipkovski

miR-132 serves as a diagnostic biomarker in gestational diabetes mellitus and its regulatory effect on trophoblast cell viability

Gestational diabetes mellitus (GDM) leads to poor pregnancy outcomes. Strategies that improve trophoblast cell function are important methods for GDM treatment. This study aimed to investigate the expression a...

Authors: Xuegui Zhou, Cuiping Xiang and Xiaoxia Zheng

Overexpression of carboxypeptidase X M14 family member 2 predicts an unfavorable prognosis and promotes proliferation and migration of osteosarcoma

Carboxypeptidase X, M14 family member 2 (CPXM2), has been associated with several human developmental disorders. However, whether CPXM2 is involved in oncogenesis or tumor progression remains unclear. Currentl...

Authors: Xin Zhao, Ronghang Li, Qian Wang, Minfei Wu and Yanbing Wang

MicroRNA-99b predicts clinical outcome of osteosarcoma and suppresses tumor cell proliferation, migration and invasion

Osteosarcoma (OS) is a malignancy predominantly occurred in children and adolescents. Numerous microRNAs are involved in the pathogenesis of various cancers. This study aimed to investigate the expression prof...

Authors: Xin Shi and Xingfa Guan

A rare simultaneous coexistence of epithelioid gastrointestinal stromal tumors and schwannoma in the stomach: a case report

Gastrointestinal stromal tumors (GISTs), a type of mesenchymal tumor in the gastrointestinal tract, are believed to be closely associated with PDGFRA and C-KIT mutations. Schwannoma in the stomach, which is an...

Authors: Yuxin Li, Yongliang Teng, Xiaofei Wei, Zhuang Tian, Yuqing Cao, Xiaona Liu and Xiumei Duan

Clinicopathologic and microenvironmental analysis of primary cutaneous CD30-positive lymphoproliferative disorders: a 26 year experience from an academic medical center in Brazil

Primary cutaneous CD30+ lymphoproliferative disorders (pc-CD30-LPD) are a group of clonal T cell lymphoproliferative disorders that despite very similar tumor histology follow different and characteristic clin...

Authors: Cristiane Rúbia Ferreira, Shuchun Zhao, José Antonio Sanches, Denis Miyashiro, Jade Cury-Martins, Raymundo Soares Azevedo, Maria C. N. Zerbini, Yasodha Natkunam and Dita Gratzinger

Treg/Th17 imbalance and its clinical significance in patients with hepatitis B-associated liver cirrhosis

Recent studies have shown that T cell-mediated cellular immune mechanisms play important roles in the progression of hepatitis B to liver cirrhosis, but the underlying mechanisms remain unclear. This present s...

Authors: Yong-Ting Lan, Zhen-li Wang, Peng Tian, Xiao-Na Gong, Yu-Chen Fan and Kai Wang

Plasmacytoid urothelial carcinoma: a rapid autopsy case report with unique clinicopathologic and genomic profile

Rapid (“warm”) autopsies of patients with advanced metastatic cancer provide important insight into the natural history, pathobiology and histomorphology of disease in treatment-resistant tumors. Plasmacytoid ...

Authors: Caroline T. Simon, Stephanie L. Skala, Paul D. Killen, Javed Siddiqui, Xuhong Cao, Yuanyuan Qiao, Hikmat Al-Ahmadie, Sandra I. Camelo-Piragua, Jeffrey Jentzen, Arul M. Chinnaiyan, Saravana M. Dhanasekaran, Zachery R. Reichert and Rohit Mehra

ALK-TPM3 rearrangement in adult renal cell carcinoma: a case report and literature review

Translocation-associated renal cell carcinoma involving ALK (ALK-tRCC) is a rare subtype of adult renal cell carcinoma (RCC) reported in recent years. It was recognized as a group of emerging /provisional RCC ...

Authors: Jing Yang, Lei Dong, Hong Du, Xiu-bo Li, Yan-xiao Liang and Guo-rong Liu

Ipsilateral breast metastasis after axillary dissection caused by epithelioid sarcoma: a case report and pathological investigation

Epithelioid sarcoma (ES) is a rare malignant soft tissue tumor, commonly occurring in distal extremities, such as fingers, hands and wrists. For oncologists and surgeons, a female patient with enlarged axillar...

Authors: Luyan Chen, Li Wang, Xiaochen Zhang, Minya Yao and Peifen Fu

JAZF1–SUZ12 endometrial stromal sarcoma forming subserosal masses with extraordinary uptake of fluorodeoxyglucose on positron emission tomography: a case report

Low-grade endometrial stromal sarcoma (ESS) is rare mesenchymal neoplasm, recently specified as harboring JAZF1–SUZ12 rearrangement. Typical JAZF1–SUZ12 ESS is slow growing, in which high uptake of fluorodeoxyglu...

Authors: Koto Fujiishi, Shigenori Nagata, Rieko Kano, Chiaki Kubo, Maasa Shirayanagi, Megumi Ozaki, Takashi Yamamoto, Katsuyuki Nakanishi, Shoji Kamiura and Shin-ichi Nakatsuka

Downregulation of miR-29c-3p is associated with a poor prognosis in patients with laryngeal squamous cell carcinoma

Laryngeal squamous cell carcinoma (LSCC) is considered to be a common malignancy of the head and neck with poor prognosis for its late diagnosis, metastasis and recurrence. Growing evidence demonstrates that t...

Authors: Ruihua Fang, Yongjin Huang, Jinghua Xie, Jianzhong Zhang and Xiaobin Ji

Elevated expression of mcl-1 inhibits apoptosis and predicts poor prognosis in patients with surgically resected non-small cell lung cancer

Mcl-1, an anti-apoptotic member of bcl-2 family, together with cleaved poly (ADC-ribose) polymerase (c-PARP) can serve as a marker of cell apoptosis. Previously we reported that treatment of Mnk inhibitor CGP5...

Authors: Qiuyuan Wen, Yuting Zhan, Hongmei Zheng, Hongjing Zang, Jiadi Luo, Yuting Zhang, Weiyuan Wang, Juan Feng, Junmi Lu, Lingjiao Chen and Songqing Fan

Increased expression of miR-601 is associated with poor prognosis and tumor progression of gastric cancer

MicroRNAs (miRNAs) have been considered to participate in many tumorigenesis, including gastric cancer (GC). Abnormal expression of miR-601 has been reported in GC, but its role is not clear. The goal of this ...

Authors: Cuili Min, Aixia Zhang and Jing Qin

LncRNA DNM3OS promotes proliferation and inhibits apoptosis through modulating IGF1 expression by sponging MiR-126 in CHON-001 cells

As a degenerative disease, osteoarthritis (OA) greatly affects aged population. The human chondrocyte cell line CHON-001, derived from normal human articular cartilage, has been widely used in vitro in osteoar...

Authors: Di Ai and Fang Yu

Low ERCC1 expression is a good predictive marker in lung adenocarcinoma patients receiving chemotherapy based on platinum in all TNM stages - a single-center study

High ERCC1 expression is thought to be related with resistance to chemotherapy based on platinum. The aim of this study was to present our institutional observations regarding to the association of ERCC1 and o...

Authors: Marina Piljić Burazer, Suzana Mladinov, Antonela Matana, Sendi Kuret, Joško Bezić and Merica Glavina Durdov

Two cases of lung neuroendocrine carcinoma with carcinoid morphology

The category of grade 3 neuroendocrine tumor (NET G3) was newly introduced in the 2017 World Health Organization (WHO 2017) classification of neuroendocrine neoplasms of the pancreas. Pancreatic NET G3 shows a...

Authors: Kenji Inafuku, Tomoyuki Yokose, Hiroyuki Ito, Daisuke Eriguchi, Joji Samejima, Takuya Nagashima, Haruhiko Nakayama, Masaki Suzuki, Kouzo Yamada and Munetaka Masuda

OLIG2 is a novel immunohistochemical marker associated with the presence of PAX3/7-FOXO1 translocation in rhabdomyosarcomas

The most frequent histological types of rhabdomyosarcoma (RMS) in children are embryonal (ERMS) and alveolar (ARMS) tumours. The majority of ARMS are characterized by the presence of PAX3/7-FOXO1 gene fusion a...

Authors: Magdalena Kaleta, Anna Wakulińska, Agnieszka Karkucińska-Więckowska, Bożenna Dembowska-Bagińska, Wiesława Grajkowska, Maciej Pronicki and Maria Łastowska

Liver metastatic basaloid squamous cell carcinoma with negative expression of pancytokeratin: a case report and literature review

Basaloid squamous cell carcinoma (BSCC) is a rare subtype of squamous cell carcinoma with a high rate of distant metastasis. BSCC occurs most commonly in the esophagus, lungs, and head and neck. However, BSCC ...

Authors: Linxiu Liu, Xuemin Xue and Liyan Xue

Targeted sequencing identifies the mutational signature of double primary and metastatic malignancies: a case report

The accurate identification of the tissue of origin is critical for optimal management of cancer patients particularly those who develop multiple malignancies; however, conventional diagnostic methods at times...

Authors: Chuangzhou Rao, Liangqin Nie, Xiaobo Miao, Analyn Lizaso and Guofang Zhao

A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma

To evaluate the clinical utility of LIM Domain Only 2 (LMO2) negative and CD38 positive in diagnosis of Burkitt lymphoma (BL).

Authors: Yifei Liu, Tingting Bian, Yanlin Zhang, Yuanyuan Zheng, Jianguo Zhang, Xiaoge Zhou and Jianlan Xie

Concordance among four commercially available, validated programmed cell death ligand-1 assays in urothelial carcinoma

Antibodies targeting the programmed cell death-1 (PD-1)/PD-ligand 1 (PD-1/PD-L1) checkpoint have shown promising clinical activity in patients with advanced urothelial carcinoma (UC). Expression of PD-L1 in UC...

Authors: Magdalena Zajac, Marietta Scott, Marianne Ratcliffe, Paul Scorer, Craig Barker, Hytham Al-Masri, Marlon C. Rebelatto and Jill Walker

An association between crypt apoptotic bodies and mucosal flattening in celiac disease patients exposed to dietary gluten

Celiac disease (CD) is characterized histologically by inflammation and villous atrophy. Villous atrophy is thought to result from a disruption of epithelial cellular proliferation and death. Epithelial cells ...

Authors: Michael Lee, Shane Betman, Alina Iuga, Hui-Min Yang, Jude Fleming, Peter H. R. Green, Benjamin Lebwohl and Stephen M. Lagana

Genetic and molecular bases of esophageal Cancer among Iranians: an update

Esophageal cancer is one of the leading causes of cancer related deaths among the Iranians. There is still a high ratio of mortality and low 5 years survival which are related to the late onset and diagnosis. ...

Authors: Mohammad Reza Abbaszadegan, Vahideh Keyvani and Meysam Moghbeli