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COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

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  1. In breast cancer (BC) Ki-67 cut-off levels, counting methods and inter- and intraobserver variation are still unresolved. To reduce inter-laboratory differences, it has been proposed that cut-off levels for Ki...

    Authors: Anette H. Skjervold, Henrik Sahlin Pettersen, Marit Valla, Signe Opdahl and Anna M. Bofin
    Citation: Diagnostic Pathology 2022 17:45
    Content type: Research Published on:

  2. Ocular cystinosis is a rare autosomal recessive disorder characterized by intralysosomal cystine accumulation in renal, ophthalmic (cornea, conjunctiva), and other organ abnormalities. Patients with ocular cys...

    Authors: Latifa Chkioua, Yessine Amri, Chaima Saheli, Wassila Mili, Sameh Mabrouk, Imen Chabchoub, Hela Boudabous, Wissem Ben Azzouz, Hadhami Ben Turkia, Salima Ferchichi, Neji Tebib, Taieb Massoud, Mohamed Ghorbel and Sandrine Laradi
    Citation: Diagnostic Pathology 2022 17:44
    Content type: Research Published on:

  3. Authors: Yumiko Hori, Katsutoshi Hirose, Michio Ozeki, Kenji Hata, Daisuke Motooka, Shinichiro Tahara, Takahiro Matsui, Masaharu Kohara, Hiroki Higashihara, Yusuke Ono, Kaishu Tanaka, Satoru Toyosawa and Eiichi Morii
    Citation: Diagnostic Pathology 2022 17:43
    Content type: Correction Published on:

    The original article was published in Diagnostic Pathology 2022 17:19

  4. Extraskeletal myxoid chondrosarcomas (EMCs) are solid tumors that have been genetically and biologically characterized. Only a few studies have discussed the role of the KIT gene or CD117 expression in EMCs, iden...

    Authors: Chen Wang, Zhi-Jie You, Xiao-Yan Chen, Jie Lin and Yi-Juan Wu
    Citation: Diagnostic Pathology 2022 17:42
    Content type: Case Report Published on:

  5. Distinguishing benign lesion from early malignancy in melanocytic lesions of the nail unit still remains a diagnostic challenge, both clinically and histopathologically. While several immunohistochemistry (IHC...

    Authors: Young Jae Kim, Chang Jin Jung, Hyoungmin Na, Woo Jin Lee, Sung Eun Chang, Mi Woo Lee, Chan-Sik Park, Youngkyoung Lim and Chong Hyun Won
    Citation: Diagnostic Pathology 2022 17:41
    Content type: Research Published on:

  6. To explore whether the “WSI Stitcher”, a program we developed for reconstructing virtual large slide through whole slide imaging fragments stitching, can improve the efficiency and consistency of pathologists ...

    Authors: Dandan Han, Jun Liao, Meng Zhang, Chenchen Qin, Mengxue Han, Chun Wu, Jinze Li, Jianhua Yao and Yueping Liu
    Citation: Diagnostic Pathology 2022 17:40
    Content type: Research Published on:

  7. IFI16 plays an important role in innate immunity against invasive microbial infection by sensing double-stranded DNA viruses due to caspase-1-dependent inflammasome activation and subsequent maturation and sec...

    Authors: Li Liu, Shuangshuang Xie, Cheng Li, Yue Guo, Xiaoyan Liu, Xiuhua Zhao, Qiang Li and Wenjun Du
    Citation: Diagnostic Pathology 2022 17:39
    Content type: Research Published on:

  9. The occurrence of endocrine cell micronests in ovarian tumors is rarely reported. To our knowledge, there are only three prior cases reported to date: one occurring in an ovarian mucinous cystadenoma, one in a...

    Authors: Katrina Collins, Sheila Segura and Michael Hwang
    Citation: Diagnostic Pathology 2022 17:37
    Content type: Case Report Published on:

  10. The early detection of coronavirus disease (COVID-19) infection to improve disease management becomes the greatest challenge. Despite the high sensitivity of RT-PCR, not only it was reported that 20–67% of inf...

    Authors: Somaye Ghasemi, Narges Nazari Harmooshi and Fakher Rahim
    Citation: Diagnostic Pathology 2022 17:36
    Content type: Research Published on:

  12. Hemangioblastoma is an indolent mesenchymal tumor most frequently occurring in the central nervous system (CNS), but can also arise extraneuraxially, as part of Von Hippel-Lindau (VHL) disease or in sporadic t...

    Authors: Xintong Wang, George K. Haines III, Meenakshi Mehrotra, Jane Houldsworth and Qiusheng Si
    Citation: Diagnostic Pathology 2022 17:34
    Content type: Case Report Published on:

  13. Most of malignant melanomas originate from skin and often metastasize to the lungs, rarely metastasizes to the liver and bone. However, imageology characters of lung metastasis tumor are commonly similar to th...

    Authors: Juan Sun, Yun-Zhu Zhu, Pan-Pan Shao, Jing Ke, Wei Wang, Qiu-Lin Sun, Jia-Bin Li and Jun Cheng
    Citation: Diagnostic Pathology 2022 17:33
    Content type: Case Report Published on:

  14. To improve identification of patients with cutaneous squamous cell carcinoma (SCC) at high risk for metastatic disease, the DecisionDx-SCC assay, a prognostic 40-gene expression profile (40-GEP) test, was deve...

    Authors: Sherri Borman, Jeff Wilkinson, Lauren Meldi-Sholl, Clare Johnson, Kelsey Carter, Kyle R. Covington, Alison L. Fitzgerald, Sarah J. Kurley, Aaron S. Farberg, Matthew S. Goldberg, Federico A. Monzon, Kristen Oelschlager and Robert W. Cook
    Citation: Diagnostic Pathology 2022 17:32
    Content type: Research Published on:

  15. Despite a reported cardiac injury in patients with new coronavirus infection, the possibility and specifics of genuine viral myocarditis in COVID-19 remains not fully clear.

    Authors: Evgeniya Kogan, Yuriy Berezovskiy, Olga Blagova, Anna Kukleva, Lyudmila Semyonova, Evgeniy Gretsov and Atadzhan Ergeshov
    Citation: Diagnostic Pathology 2022 17:31
    Content type: Short report Published on:

  16. Pulmonary enteric adenocarcinoma (PEAC) has distinctive clinical outcomes, radiographic, pathological and molecular characteristics. The prognosis of patients with PEAC was poor. However, molecular profiles an...

    Authors: Min Xie, Dong Chen, Yong Li, Xiansheng Liu, Dong Kuang and Xiaochen Li
    Citation: Diagnostic Pathology 2022 17:30
    Content type: Research Published on:

  17. SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4-deficient thoracic sarcoma (SMARCA4-DTS) is a rare disease that has recently been described as an entity. It is...

    Authors: Yusuke Kito, Keisuke Kawashima, Chiemi Saigo, Masayoshi Hasegawa, Shusuke Nomura, Takuya Mikamo, Yuki Hanamatsu, Yasuhiro Matsuo and Tamostu Takeuchi
    Citation: Diagnostic Pathology 2022 17:29
    Content type: Case Report Published on:

  18. The underlying mechanism of IgA vasculitis (IgAV) and IgA vasculitis with nephritis (IgAVN) remains unclear. Therefore, there are no accurate diagnostic methods. Lipid metabolism is related to many immune rela...

    Authors: Ying Liu, Min Wen, Qingnan He, Xiqiang Dang, Shipin Feng, Taohua Liu, Xuewei Ding, Xiaoyan Li and Xiaojie He
    Citation: Diagnostic Pathology 2022 17:28
    Content type: Research Published on:

  19. Anaplastic lymphoma kinase (ALK) gene rearrangements, have been identified in approximately 2-7% of patients with lung adenocarcinoma (LUAD). However, co-occurrence of double ALK fusions in one patient was rare. ...

    Authors: Hong Tao, Zhe Liu, Jing Mu, Fei Gai, Zhan Huang and Liang Shi
    Citation: Diagnostic Pathology 2022 17:27
    Content type: Case Report Published on:

  20. Large cell neuroendocrine carcinoma (LCNEC) is a high-grade malignant pulmonary neuroendocrine tumour. The distinction of pulmonary large cell carcinoma (LCC) and LCNEC is based on the presence of neuroendocri...

    Authors: Zuoyu Liang, Weiya Wang, Qianrong Hu, Ping Zhou, Ying Zhang, Yuan Tang, Qian Wu, Yiyun Fu, Xue Li, Yang Shao and Lili Jiang
    Citation: Diagnostic Pathology 2022 17:26
    Content type: Research Published on:

  21. Pulmonary carcinoid tumors rarely coexist with non-small cell lung carcinoma, and only nine cases have been reported previously. The pathogenesis and origin of these combined tumors remain unclear because of i...

    Authors: Chihiro Inoue, Sachiko Konosu-Fukaya, Kazuhiro Murakami, Ryoko Saito-Koyama, Hirofumi Watanabe, Hideki Mitomo, Naoya Ishibashi, Takafumi Sugawara, Toshiharu Tabata, Hironobu Sasano and Yasuhiro Nakamura
    Citation: Diagnostic Pathology 2022 17:25
    Content type: Case Report Published on:

  22. Currently, breast cancers are divided into four major molecular subtypes. The distinction between the luminal A and luminal B subtypes is mainly based on the cellular proliferation indices and is assessed by t...

    Authors: Dorsay Sadeghian, Hana Saffar, Pouya Mahdavi Sharif, Vahid Soleimani and Behnaz Jahanbin
    Citation: Diagnostic Pathology 2022 17:24
    Content type: Research Published on:

  23. The incidence of tongue cancer in young adults is on the rise. This trend is more pronounced in females. Although the aetiology is still unclear, there is mounting evidence that genetic syndromes can play a ke...

    Authors: Takako Eva Yabe, Kylie King, Susan Russell, Laveniya Satgunaseelan, Ruta Gupta, James Chen and Bruce Ashford
    Citation: Diagnostic Pathology 2022 17:23
    Content type: Case Report Published on:

  24. SWItch Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex functions collectively as a tumor suppressor and the inactivation of any of its constituent components is frequently associated with tumor ...

    Authors: Wenjuan Xu, Haiying Dong, Guoqing Ru and Ming Zhao
    Citation: Diagnostic Pathology 2022 17:22
    Content type: Case Report Published on:

  25. Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a strong cancer stem cell marker in colorectal cancer; however, there are many unclear aspects of LGR5 expression in pancreatic cancer. It has...

    Authors: Masato Kamakura, Takeshi Uehara, Mai Iwaya, Shiho Asaka, Shota Kobayashi, Tomoyuki Nakajima, Yasuhiro Kinugawa, Tadanobu Nagaya, Takahiro Yoshizawa, Akira Shimizu, Hiroyoshi Ota and Takeji Umemura
    Citation: Diagnostic Pathology 2022 17:21
    Content type: Research Published on:

  26. Ki-67 standard reference card (SRC) and artificial intelligence (AI) software were used to evaluate breast cancer Ki-67LI. We established training and validation sets and studied the repeatability inter-observ...

    Authors: Lina Li, Dandan Han, Yongqiang Yu, Jinze Li and Yueping Liu
    Citation: Diagnostic Pathology 2022 17:20
    Content type: Research Published on:

  27. Fibro-adipose vascular anomaly (FAVA) is a rare and new entity of vascular anomaly. Activating mutations in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene were identified...

    Authors: Yumiko Hori, Katsutoshi Hirose, Michio Ozeki, Kenji Hata, Daisuke Motooka, Shinichiro Tahara, Takahiro Matsui, Masaharu Kohara, Hiroki Higashihara, Yusuke Ono, Kaishu Tanaka, Satoru Toyosawa and Eiichi Morii
    Citation: Diagnostic Pathology 2022 17:19
    Content type: Short report Published on:

    The Correction to this article has been published in Diagnostic Pathology 2022 17:43

  28. As a rare salivary gland malignancy, clear cell carcinoma (CCC) is easily misdiagnosed. This study identified the features that allow better recognition of the clinicopathological and molecular characteristics...

    Authors: Lanlan Xuan, Suxia Wang, Jianguo Wei, Jianwei Yuan and Honggang Liu
    Citation: Diagnostic Pathology 2022 17:18
    Content type: Research Published on:

  29. Immunohistochemistry (IHC) using monoclonal and polyclonal antibodies is a useful diagnostic method for detecting pathogen antigens in fixed tissues, complementing the direct diagnosis of infectious diseases b...

    Authors: Hamadou Oumarou Hama, Gérard Aboudharam, Rémi Barbieri, Hubert Lepidi and Michel Drancourt
    Citation: Diagnostic Pathology 2022 17:17
    Content type: Review Published on:

  30. The human amphoterin-induced gene and open reading frame (AMIGO) was identified as a novel cell adhesion molecule of type I transmembrane protein. AMIGO2 is one of three members of the AMIGO family (AMIGO1, 2,...

    Authors: Keisuke Goto, Mitsuhiko Osaki, Runa Izutsu, Hiroshi Tanaka, Ryo Sasaki, Akimitsu Tanio, Hiroyuki Satofuka, Yasuhiro Kazuki, Manabu Yamamoto, Hiroyuki Kugoh, Hisao Ito, Mitsuo Oshimura, Yoshiyuki Fujiwara and Futoshi Okada
    Citation: Diagnostic Pathology 2022 17:16
    Content type: Short report Published on:

  32. Currently, FLT3 internal tandem duplication (ITD) is tested by fragment analysis. With next-generation sequencing (NGS), however, not only FLT3 ITD but also other mutations can be detected, which can provide more...

    Authors: Jin Ju Kim, Kwang Seob Lee, Taek Gyu Lee, Seungjae Lee, Saeam Shin and Seung-Tae Lee
    Citation: Diagnostic Pathology 2022 17:14
    Content type: Research Published on:

  33. STAT3 plays an important role in cervical cancer. LC3B, the most potential molecular biomarker of autophagy that may promote or inhibit cancer progression, can be downregulated by STAT3. However the role of ST...

    Authors: Lin Wu, Bowen Shen, Junpeng Li, Huirong Zhang, Ke Zhang, Yao Yang, Zhenyu Zu, Dongxiang Shen and Min Luo
    Citation: Diagnostic Pathology 2022 17:13
    Content type: Research Published on:

  34. The aim of this study was to evaluate the clinicopathological factors and prognosis of mucinous carcinoma (MC) with infiltrative invasion, MC with expansile invasion, and high-grade serous carcinoma (HGSC).

    Authors: Taira Hada, Morikazu Miyamoto, Hiroki Ishibashi, Hiroko Matsuura, Soichiro Kakimoto, Hideki Iwahashi, Hitoshi Tsuda and Masashi Takano
    Citation: Diagnostic Pathology 2022 17:12
    Content type: Research Published on:

  35. Hepatitis B Virus (HBV) infection is the major risk factor for hepatocellular carcinoma (HCC) in East Asia. Here we aimed to further investigate the abundance of viral antigen and DNA within HBV-related HCC an...

    Authors: Ye Zheng, Mingzhu Xu, Dong Zeng, Haitao Tong, Yuhan Shi, Yanling Feng and Xiaonan Zhang
    Citation: Diagnostic Pathology 2022 17:11
    Content type: Research Published on:

  36. UPK2 exhibits excellent specificity for urothelial carcinoma (UC). UPK2 evaluation can be useful in making the correct diagnosis of UC. However, UPK2 detection by immunohistochemistry (IHC) has relatively low ...

    Authors: Jiangli Lu, Ming Zhao, Chenyan Wu, Chengbiao Chu, Chris Zhiyi Zhang and Yun Cao
    Citation: Diagnostic Pathology 2022 17:10
    Content type: Research Published on:

  37. Cytomegalovirus (CMV) has been recognized as one of the frequently occurring opportunistic infections (OIs) reported in the patients having human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/...

    Authors: Lei Sun, Jia-min Chen, Kun Yang, Liang Zhang, Zhi-yuan Ma, Xiang-mei Chen, Man Li, Xingang Zhou, Ping Li, Hong-xin Zhao, Jiang Xiao, Li-ming Qi and Peng Wang
    Citation: Diagnostic Pathology 2022 17:9
    Content type: Research Published on:

  38. Yolk sac tumor (YST) is a germ cell tumor. It is primarily located in the gonads but can also occur extragonadally (extragonadal yolk sac tumor - EGYST), most commonly in the pelvis, retroperitoneum or mediast...

    Authors: Vladimír Šámal, Tomáš Jirásek, Vít Paldus, Igor Richter and Ondřej Hes
    Citation: Diagnostic Pathology 2022 17:8
    Content type: Case Report Published on:

  39. A number of biomarkers have the potential of differentiating between primary lung tumours and secondary lung tumours from the gastrointestinal tract, however, a standardised panel for that purpose does not exi...

    Authors: Bachar Alabdullah and Amir Hadji-Ashrafy
    Citation: Diagnostic Pathology 2022 17:7
    Content type: Research Published on:

  40. Desmoplastic small round cell tumor (DSRCT) is a sporadic, highly malignant tumor with a poor prognosis. The abdomen and pelvis have been reported as the primary localization sites. However, to the best of our...

    Authors: Jiayu Zhou, Qingling Li, Baihua Luo, Xiaodan Fu, Chunlin Ou, Xiaomei Gao, Zhijie Xu, Deyun Feng and Keda Yang
    Citation: Diagnostic Pathology 2022 17:6
    Content type: Case Report Published on:

  41. According to 2018 ASCO/CAP guideline, HER2 FISH-equivocal breast cancers will be categorized as HER2 negative except those with IHC 3+. However, whether or not HER2 FISH-equivocal breast cancers was a heteroge...

    Authors: Hui Kong, Qianming Bai, Anqi Li, Xiaoyan Zhou and Wentao Yang
    Citation: Diagnostic Pathology 2022 17:5
    Content type: Research Published on:

  42. NUT (nuclear protein in testis) midline carcinoma (NMC) is a rapidly progressive tumor arising from midline structures. Recent cases have reported that the poor prognosis with a median survival of 6.7 months a...

    Authors: Jin Jiang, Yikun Ren, Chengping Xu and Xing Lin
    Citation: Diagnostic Pathology 2022 17:4
    Content type: Case Report Published on:

  43. Immunodeficient patients, including the recipients of solid organs, exhibit an increase in the incidence of neoplasms. Post-transplant smooth muscle tumor (PTSMT) is a distinct and infrequent entity of these g...

    Authors: Mohammad Hossein Anbardar, Neda Soleimani, Dornaz Safavi, Ahad Eshraghian and Abbas Ayoub
    Citation: Diagnostic Pathology 2022 17:3
    Content type: Case Report Published on:

  44. Synaptophysin (SYN), chromogranin A (CGA), CD56 and insulinoma-associated protein 1 (INSM1) are proposed neuroendocrine (NE) markers used for diagnosis of pulmonary NE tumors. These NE markers have been identi...

    Authors: Lu Yu, Yuting Dong, Jin Xue, Sanpeng Xu, Guoping Wang, Dong Kuang and Yaqi Duan
    Citation: Diagnostic Pathology 2022 17:2
    Content type: Research Published on:

  46. Pseudomyxoma peritonei (PMP) is a complex and partially understood disease defined by mucin deposits in the peritoneal cavity, mostly of appendiceal origin caused by the rupture of a mucocele often containing ...

    Authors: Marie Csanyi-Bastien, France Blanchard, Aude Lamy and Jean-Christophe Sabourin
    Citation: Diagnostic Pathology 2021 16:119
    Content type: Case Report Published on:

  47. Transmission of malignancy is a notable problem that cannot always be absolutely predicted at the time of transplantation. In particular, donor-derived transmission of synovial sarcoma in solid-organ transplan...

    Authors: Jian Zhang, Yang Yang, Ye Tian, Ruifang Xu and Jun Lin
    Citation: Diagnostic Pathology 2021 16:118
    Content type: Case Report Published on:

  48. Pancreatic medullary carcinoma (PMC) is a rare pancreatic tumor, usually showing the presence of microsatellite instability, mostly MLH1 silencing, and a wild-type KRAS mutation status. We report here a PMC ar...

    Authors: Camille Verocq, Marie-Lucie Racu, Dominique Bafort, Gloria Butorano, Luis Perez-Casanova Garcia, Julie Navez, Marc Witterwulghe, Kieran Sheahan, Niall Swan, Jean Closset, Jean-Luc Van Laethem, Calliope Maris and Nicky D’Haene
    Citation: Diagnostic Pathology 2021 16:117
    Content type: Case Report Published on:

  49. As a rare clinical tumor syndrome with an indolent clinical course and lack of pathognomonic symptoms, pseudomyxoma peritonei (PMP) is usually diagnosed at an advanced stage. In-depth pathological analysis is ...

    Authors: Ru Ma, Yu-Lin Lin, Xin-Bao Li, Feng-Cai Yan, Hong-Bin Xu, Zheng Peng and Yan Li
    Citation: Diagnostic Pathology 2021 16:116
    Content type: Research Published on:

  50. Synovial sarcomas are a rare type of high-grade sarcomas with unknown cell origin. They arise predominantly in the soft tissues but rarely in the stomach. We recently encountered a rare case of minute gastric ...

    Authors: Kanako Yoshiyasu, Hiroshi Kono, Yudai Hojo, Yoshinori Ishida, Akio Tamura, Keisuke Nakai, Tadayuki Oshima, Hiroto Miwa, Hisashi Shinohara and Seiichi Hirota
    Citation: Diagnostic Pathology 2021 16:115
    Content type: Case Report Published on:
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Diagnostic Pathology

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