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  1. Madelung’s disease or multiple symmetric lipomatosis (MSL) is a rare disorder of unknown etiology which typically presents symmetrically subcutaneous accumulation of non-encapsulated adipose tissue which slowl...

    Authors: Maddalena Borriello, Alessandro Lucidi, Arnaldo Carbone, Vito Iannone and Gabriella Ferrandina
    Citation: Diagnostic Pathology 2012 7:116
    Content type: Case Report Published on:

  2. Special AT-rich sequence-binding protein 1 (SATB1) is a global gene regulator that has been reported to confer malignant behavior and associate with poor prognosis in several cancer forms. SATB1 expression has...

    Authors: Björn Nodin, Henrik Johannesson, Sakarias Wangefjord, Darran P O’Connor, Kajsa Ericson Lindquist, Mathias Uhlén, Karin Jirström and Jakob Eberhard
    Citation: Diagnostic Pathology 2012 7:115
    Content type: Research Published on:

  3. Primary lymphoma of adrenal glands is rare, and non-B-cell lymphoma associated with pyothorax is also very rare. Here we report the first autopsy case of non-B-cell lymphoma in bilateral adrenal glands of a 79...

    Authors: Tomohide Tsukahara, Akira Takasawa, Masaki Murata, Kazuyoshi Okumura, Masato Nakayama, Noriyuki Sato and Tadashi Hasegawa
    Citation: Diagnostic Pathology 2012 7:114
    Content type: Case Report Published on:

  4. Giant cell angioblastoma (GCAB) is an extremely rare soft tissue tumor of early childhood and only five cases have been described to date. As such the clinical, pathological, and prognostic features are poorly...

    Authors: Rong-Jun Mao, Zhi-Ming Jiang, Hui-Zhen Zhang, Xiong-Zeng Zhu and Qing-Ling Zhang
    Citation: Diagnostic Pathology 2012 7:113
    Content type: Case Report Published on:

  6. Previous studies have demonstrated that claudin-6 functions as a cancer suppressor in human MCF-7 breast cancer cells. The growth inhibitory effect could be attributed to inhibition of cell proliferation and i...

    Authors: Yaxiong Guo, Xiaoming Xu, Zhijing Liu, Ting Zhang, Xiaowei Zhang, Liping Wang, Min Wang, Yuanyuan Liu, Yan Lu, Yunpeng Liu and Chengshi Quan
    Citation: Diagnostic Pathology 2012 7:111
    Content type: Research Published on:

  7. Determining the primary site of metastatic cancer with confidence can be challenging. Pathologists commonly use a battery of immunohistochemical (IHC) stains to determine the primary site. Gene expression prof...

    Authors: Anand Kulkarni, Raji Pillai, Ashley M Ezekiel, W David Henner and Charles R Handorf
    Citation: Diagnostic Pathology 2012 7:110
    Content type: Short report Published on:

  8. Pathologic diagnosis of stage I idiopathic membranous nephropathy (MN-I) requires electron microscopy or immunohistochemistry that shows a glomerular capillary staining pattern of IgG and C3. However, it is no...

    Authors: Rui Zhang, Zhi-yong Zheng, Jian-song Lin, Li-juan Qu and Feng Zheng
    Citation: Diagnostic Pathology 2012 7:109
    Content type: Research Published on:

  9. We present a case of a 62-year-old man who underwent total hip arthroplasty for treatment of pathologic femoral neck fracture associated with adefovir dipivoxil-induced osteomalacia. He had a 13-month history ...

    Authors: Motoyuki Tanaka, Takao Setoguchi, Yasuhiro Ishidou, Yoshiya Arishima, Masataka Hirotsu, Yoshinobu Saitoh, Shunsuke Nakamura, Hironori Kakoi, Satoshi Nagano, Masahiro Yokouchi, Junichi Kamizono and Setsuro Komiya
    Citation: Diagnostic Pathology 2012 7:108
    Content type: Case Report Published on:

  10. Persistent polyclonal B-cell lymphocytosis (PPBL) is rare and intriguing hematological disorder predominantly reported in young to middle- aged smoking women. It is characterized by persistent moderate polyclo...

    Authors: Ping Sun and Ridas Juskevicius
    Citation: Diagnostic Pathology 2012 7:107
    Content type: Case Report Published on:

  11. The current paper describes a case of prostatic adenocarcinoma metastatic to the skin presenting as an extrammamary Paget's disease, a very rare and poorly characterised morphological entity. We report a case ...

    Authors: Eugen Bogdan Petcu, Aldo Gonzalez-Serva, Robert G Wright, Mark Slevin and Klara Brinzaniuc
    Citation: Diagnostic Pathology 2012 7:106
    Content type: Case Report Published on:

  12. Glandular lesions are often problematic for diagnostic cervical pathology. The survival of patients with adenocarcinoma is significantly poorer than that of patient with squamous cell carcinoma. One reason for...

    Authors: Johji Imura, Yoshiaki Uchida, Kazuhiro Nomoto, Kazuhito Ichikawa, Shigeki Tomita, Tatsuo Iijima and Takahiro Fujimori
    Citation: Diagnostic Pathology 2012 7:105
    Content type: Research Published on:

  13. The main focus of several studies concerned with cancer progression and metastasis is to analyze the mechanisms that allow cancer cells to interact and quickly adapt with their environment. Integrins, a family...

    Authors: Petra Barros dos Santos, Juliana S Zanetti, Alfredo Ribeiro-Silva and Eduardo IC Beltrão
    Citation: Diagnostic Pathology 2012 7:104
    Content type: Research Published on:

  14. Protein kinase RNA (PKR-regulated) is a double-stranded RNA activated protein kinase whose expression is induced by interferon. The role of PKR in cell growth regulation is controversial, with some studies sup...

    Authors: Amal A Mohamed, Ola H Nada and Mohamed A El Desouky
    Citation: Diagnostic Pathology 2012 7:103
    Content type: Research Published on:

  15. Neuroendocrine tumor (NET) in adenoma of the gastrointestinal tract is a rare mixed glandular-endocrine neoplasm and has uncommonly been described mostly in the colon. Histologically, this tumor is composed of...

    Authors: Sun-Mi Lee, Soomin Ahn, Yun Kyung Lee, Kee-Taek Jang, Cheol Keun Park and Kyoung-Mee Kim
    Citation: Diagnostic Pathology 2012 7:102
    Content type: Case Report Published on:

  16. In this study, the clinical and morphological features of vesiculobullous lesions observed in Kaposi sarcoma are analyzed, and the features of bullous Kaposi sarcoma cases are emphasized.

    Authors: Nilüfer Onak Kandemir, Figen Barut, Banu Doğan Gün, Nilgün Solak Tekin, Sevinç Hallaç Keser and Şükrü Oğuz Özdamar
    Citation: Diagnostic Pathology 2012 7:101
    Content type: Research Published on:

  17. Autoimmune sclerosing cholangitis is an overlap syndrome characterized by features of both autoimmune hepatitis and primary sclerosing cholangitis, the latter usually involving the large bile ducts. Autoimmune...

    Authors: Erling Peter Larsen, Allan Bayat and Mogens Vyberg
    Citation: Diagnostic Pathology 2012 7:100
    Content type: Case Report Published on:

  20. To distinguish between malignant and benign lesions of the thyroid gland histological demonstration is often required since the fine-needle aspiration biopsy method applied pre-operatively has some limitations...

    Authors: Leandro Luongo de Matos, Adriana Braz Del Giglio, Carolina Ogawa Matsubayashi, Michelle de Lima Farah, Auro Del Giglio and Maria Aparecida da Silva Pinhal
    Citation: Diagnostic Pathology 2012 7:97
    Content type: Review Published on:

  21. L1 cell adhesion molecule (L1CAM), as a member of the immunoglobulin superfamily, has recently been observed in a variety of human malignancies. However, no data of L1CAM are available for hepatocellular carci...

    Authors: Xiaodong Guo, Lu Xiong, Lin Zou, Ting Sun, Jing Zhang, Hanwei Li, Ruiyun Peng and Jingmin Zhao
    Citation: Diagnostic Pathology 2012 7:96
    Content type: Research Published on:

  22. Papillary renal cell carcinoma (RCC) represents a rare tumor, which is divided, based on histological criteria, into two subtypes. In contrast to type I papillary RCC type II papillary RCC shows a worse progno...

    Authors: Carl Ludwig Behnes, Bernhard Hemmerlein, Arne Strauss, Heinz-Joachim Radzun and Felix Bremmer
    Citation: Diagnostic Pathology 2012 7:95
    Content type: Research Published on:

  23. A 78-year-old Japanese male noticed a difficulty in the beginning of standing up, followed by 7a progressive numbness of extremities with pain, Bell’s palsy, dysarthria, and difficulty in swallowing. A clinici...

    Authors: Sohsuke Yamada, Akihide Tanimoto, Atsunori Nabeshima, Takashi Tasaki, Ke-Yong Wang, Shohei Kitada, Hirotsugu Noguchi and Yasuyuki Sasaguri
    Citation: Diagnostic Pathology 2012 7:94
    Content type: Case Report Published on:

  24. Hemophilia A is an X linked recessive hemorrhagic disorder caused by mutations in the F8 gene that lead to qualitative and/or quantitative deficiencies of coagulation factor VIII (FVIII). Molecular diagnosis of h...

    Authors: Hejer Elmahmoudi, Houssein Khodjet-el-khil, Edvard Wigren, Asma Jlizi, Kaouther Zahra, Dorothé Pellechia, Christine Vinciguerra, Balkis Meddeb, Amel Ben Ammar Elggaaied and Emna Gouider
    Citation: Diagnostic Pathology 2012 7:93
    Content type: Research Published on:

  25. Inherited factor VII (FVII) deficiency is a rare disorder characterized by a bleeding phenotype varying from mild to severe. To date, more than 200 mutations have been described along the F7 gene encoding for FVI...

    Authors: Hejer Elmahmoudi, Fatma Ben-lakhal, Wijden Elborji, Asma Jlizi, Kaouther Zahra, Rim Sassi, Moez Zorgan, Balkis Meddeb, Amel Elgaaied Ben Ammar and Emna Gouider
    Citation: Diagnostic Pathology 2012 7:92
    Content type: Research Published on:

  26. The differences between invasive lobular and ductal carcinomas affect the diagnostic and therapeutic management for patients with breast cancer. In most cases, this can be accomplished because of distinct hist...

    Authors: Hacer Haltas, Reyhan Bayrak, Sibel Yenidunya, Dilek Kosehan, Meral Sen and Kayihan Akin
    Citation: Diagnostic Pathology 2012 7:91
    Content type: Case Report Published on:

  27. Translationally Controlled Tumour protein is a multifunctional calcium binding protein which has an important role in apoptosis, calcium levels balance and immunological response. The aim of this study was to ...

    Authors: Cinzia Batisti, Maria R Ambrosio, Bruno J Rocca, Gian M Tosi, Jean C Sanchez, Felice Arcuri, Marcella Cintorino and Sergio A Tripodi
    Citation: Diagnostic Pathology 2012 7:90
    Content type: Research Published on:

  28. Squamous metaplasia presenting in noninvasive mucinous cystic neoplasm (MCN) of the pancreas is extremely rare. We described a case of 39-year-old Chinese female with a 5-year history of a slow growing mass in...

    Authors: Peifeng Li, Yingmei Wang, Qingqing Zhang, Yixiong Liu, Yang Lv and Zhe Wang
    Citation: Diagnostic Pathology 2012 7:89
    Content type: Case Report Published on:

  29. Coronary artery disease (CAD) is a multifactorial disease where genetic and environmental factors interact in complex ways to cause the disease. Heat shock protein genes are involved in the progress of CAD. Th...

    Authors: Mohamed Yahia Hrira, Latifa Chkioua, Afef Slimani, Henda Chahed, Habib Mosbah, Hamda Ben Khaldoun, Salima Ferchichi, Faouzi Addad and Abdelhedi Miled
    Citation: Diagnostic Pathology 2012 7:88
    Content type: Research Published on:

  30. Chronic obstructive pulmonary disease (COPD) is a disorder associated to cigarette smoke and lung cancer (LC). Since epigenetic changes in oncogenes and tumor suppressor genes (TSGs) are clearly important in t...

    Authors: Leda Guzmán, María Soledad Depix, Ana María Salinas, Rosa Roldán, Francisco Aguayo, Alejandra Silva and Raul Vinet
    Citation: Diagnostic Pathology 2012 7:87
    Content type: Research Published on:

  31. The immunohistochemical demonstration of Enhancer of zeste homologue 2 (EZH2) proved to be a useful marker in several tumor types. It has been described to distinguish reliably hepatocellular carcinomas from l...

    Authors: Szofia Hajósi-Kalcakosz, Katalin Dezső, Edina Bugyik, Csaba Bödör, Sándor Paku, Zoltán Pávai, Judit Halász, Krisztina Schlachter, Zsuzsa Schaff and Péter Nagy
    Citation: Diagnostic Pathology 2012 7:86
    Content type: Research Published on:

  32. A 54 year old lady presented for routine excision of a scalp lesion thought clinically to represent a sebaceous cyst of the right occiput. 4 years earlier she underwent total abdominal hysterectomy and right s...

    Authors: Shane Corcoran, Aisling M Hogan, Tamas Nemeth, Fadel Bennani, Francis J Sullivan, Waqar Khan and Kevin Barry
    Citation: Diagnostic Pathology 2012 7:85
    Content type: Case Report Published on:

  34. Inflammatory myofibroblastic tumor is a rare benign lesion whose tumor origin is now proven. It represents 0.7% of all lung tumors. We report the case of a three-year-old child who suffered from a chronic coug...

    Authors: Nawal Hammas, Laila Chbani, Mohammed Rami, Meryem Boubbou, Sara Benmiloud, Youssef Bouabdellah, Siham Tizniti, Mustapha Hida and Afaf Amarti
    Citation: Diagnostic Pathology 2012 7:83
    Content type: Case Report Published on:

  35. Malignant melanoma is the most lethal form of skin cancer with a variable clinical course even in patients with thin melanomas and localized disease. Despite increasing insights into melanoma biology, no progn...

    Authors: Björn Nodin, Marie Fridberg, Liv Jonsson, Julia Bergman, Mathias Uhlén and Karin Jirström
    Citation: Diagnostic Pathology 2012 7:82
    Content type: Research Published on:

  36. Immunohistochemistry using antibody cocktails against basal cell specific and cancer-associated markers is important in the diagnosis of prostate carcinoma in needle biopsies. We compared the usefulness for de...

    Authors: Parag Deepak Dabir, Peter Ottosen, Søren Høyer and Stephen Hamilton-Dutoit
    Citation: Diagnostic Pathology 2012 7:81
    Content type: Research Published on:

  37. Fascin and CD44v6 may have significant roles as biomarkers in tumour progression and metastasis. In endometrioid carcinomas, the fascin expression profile is less defined, and the significance of CD44v6 is unc...

    Authors: Banu Dogan Gun, Burak Bahadir, Sibel Bektas, Figen Barut, Gamze Yurdakan, Nilufer Onak Kandemir and Sukru Oguz Ozdamar
    Citation: Diagnostic Pathology 2012 7:80
    Content type: Research Published on:

  38. Peripheral T-cell lymphomas not otherwise specified are generally considered aggressive non-Hodgkin lymphomas, because of poor natural outcome and response to therapy. They show a complex karyotype without any...

    Authors: Gabriella Aquino, Renato Franco, Fioravante Ronconi, Annamaria Anniciello, Luigi Russo, Annarosaria De Chiara and Luigi Panico
    Citation: Diagnostic Pathology 2012 7:79
    Content type: Case Report Published on:

  39. Bisphosphonates are recommended in the treatment of osteoporosis and some cancers, in which case they prevent the appearance of bone metastasis. The patients taking bisphosphonates are at increased risk of dev...

    Authors: Eugen B Petcu, Saso Ivanovski, Robert G Wright, Mark Slevin, Rodica I Miroiu and Klara Brinzaniuc
    Citation: Diagnostic Pathology 2012 7:78
    Content type: Letter to the Editor Published on:

  40. Paragangliomas are rare neoplasms arising from undifferentiated cells of the primitive neural crest. We report a case of a 57-year-old patient with renal pigmented paraganglioma that was an incidental finding....

    Authors: Ling Zhao, Jie Luo, Honglei Zhang and Jiping Da
    Citation: Diagnostic Pathology 2012 7:77
    Content type: Case Report Published on:

  41. Gastrointestinal (GI) lymphomas are very common types of extranodal lymphomas, and we hypothesize there are regional differences in subtype, distribution in the GI tract, and epidemiological features among the...

    Authors: Joshua Warrick, Jingqin Luo, Diane Robirds, Julie Branson, John L Frater, Friederike Kreisel, Anjum Hassan and TuDung T Nguyen
    Citation: Diagnostic Pathology 2012 7:76
    Content type: Research Published on:

  42. Acute promyelocytic leukemia is a cytogenetically well defined entity. Nevertheless, some features observed at diagnosis are related to a worse outcome of the patients.

    Authors: Mariana R. B. De Mello, Dulcineia M Albuquerque, Fernanda Gonçalves Pereira-Cunha, Krizzia B Albanez, Katia B. B. Pagnano, Fernando F Costa, Konradin Metze and Irene Lorand-Metze
    Citation: Diagnostic Pathology 2012 7:75
    Content type: Research Published on:

  43. Primary malignant melanoma of the duodenum is an unusual oncologic entity. Patients usually present the similar clinical symptoms like other common tumors in this site. And there are no specific radiological f...

    Authors: Hongxia Li, Qinhe Fan, Zhen Wang, Hai Xu, Xiao Li, Weiming Zhang and Zhihong Zhang
    Citation: Diagnostic Pathology 2012 7:74
    Content type: Case Report Published on:

  44. After skin cancer, breast cancer is the most common malignancy in women. Tumors of unknown origin account for 5-15% of malignant neoplasms, with 1.5% being breast cancer. An immunohistochemical panel with conv...

    Authors: Maria de las Mercedes Noriega, Fernando Paesani, Florencia Perazzo, Néstor Lago, Hugo Krupitzki, Silvana Nieto, Alejandro Garcia, Alejandra Avagnina, Boris Elsner and Valeria Cecilia Denninghoff
    Citation: Diagnostic Pathology 2012 7:73
    Content type: Research Published on:

  46. It is not clear if sentinel lymph node (SLN) mapping can improve outcomes in patients with colorectal cancers. The purpose of this study was to determine the prognostic values of ex vivo sentinel lymph node (S...

    Authors: Fu-Long Wang, Fang Shen, De-Sen Wan, Zhen-Hai Lu, Li-Ren Li, Gong Chen, Xiao-Jun Wu, Pei-Rong Ding, Ling-Heng Kong and Zhi-Zhong Pan
    Citation: Diagnostic Pathology 2012 7:71
    Content type: Research Published on:

  48. Immunohistochemical (IHC) assays performed on formalin-fixed paraffin-embedded (FFPE) tissue sections traditionally have been semi-quantified by pathologist visual scoring of staining. IHC is useful for valida...

    Authors: Anthony E Rizzardi, Arthur T Johnson, Rachel Isaksson Vogel, Stefan E Pambuccian, Jonathan Henriksen, Amy PN Skubitz, Gregory J Metzger and Stephen C Schmechel
    Citation: Diagnostic Pathology 2012 7:42
    Content type: Research Published on:

  49. The aberrant expression of regenerating islet-derived family member, 4 (Reg IV) has been found in various human cancers. However, the roles of Reg IV gene and its encoding product in human glioma have not been...

    Authors: Qi Wang, Jianping Deng, Jun Yuan, Liang Wang, Zhenwei Zhao, Shiming He, Yongsheng Zhang and Yanyang Tu
    Citation: Diagnostic Pathology 2012 7:69
    Content type: Research Published on:

  50. The prediction of pathological outcomes prior to surgery remains a challenging problem for the appropriate surgical indication of prostate cancer. This study was performed to identify preoperative values predi...

    Authors: Fumio Ishizaki, Noboru Hara, Hiroshi Koike, Makoto Kawaguchi, Akira Tadokoro, Itsuhiro Takizawa, Tsutomu Nishiyama, Kota Takahashi and Rudolf Hohenfellner
    Citation: Diagnostic Pathology 2012 7:68
    Content type: Research Published on:
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Diagnostic Pathology

ISSN: 1746-1596

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