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Table 1 Clinical data and histology of Medullomyoblastoma

From: The role of immunohistochemistry in medullomyoblastoma – a case series highlighting divergent differentiation

Case No.

Age#/Sex

Presentation

Duration of symptoms (days)

Imaging (CT/MRI)

Histopathological features

1

28 y/M

Headache, vomiting, ataxic gait

14

Posterior fossa SOL

Predominant areas of PNE cells, nodules of cells showing smooth muscle differentiation, cartilaginous islands

2

6 mon/F

Vomiting, altered sensorium

15

Posterior fossa SOL, hydrocephalus

Predominant areas of PNE cells, RMB areas present, focal cartilaginous and epithelial differentiation

3

4 y/M

Recurrent headache, vomiting

20

Posterior fossa contrast enhancing SOL

Co-dominant RMB and PNE areas, many strap cells present

4

3 y/M

Headache, vomiting, altered sensorium

20

Posterior fossa SOL

Predominant areas of PNE cells, RMB areas present with strap cells

5

4 y/M

Persistant vomiting

60

Posterior fossa SOL, hydrocephalus

Predominant areas of PNE cells, RMB areas with strap cells present

6

8 y/M

Headache, vomiting, vertigo

60

Posterior fossa SOL

Predominant areas comprise of larger atypical cells with vesicular nuclei and moderate amount of cytoplasm, no typical strap cells present, rest of the areas show PNE cells

7

4 y/M

Vomiting, altered sensorium

30

Posterior fossa SOL

Predominant areas of PNE cells, RMB areas show strap cells

  1. PNE – Primitive neuroectodermal; RMB – Rhabdomyoblastic; SOL – Space occupying lesion; Age# y – years & mon-months