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  1. Research

    GATA3 is a sensitive marker for primary genital extramammary paget disease: an immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15

    GATA-binding protein 3 (GATA3) has been identified as a sensitive marker for breast carcinoma but its sensitivity in primary genital extramammary Paget diseases (EMPDs) has not been well studied.

    Ming Zhao, Lixin Zhou, Li Sun, Yan Song, Yunquan Guo, Xun Zhang, Feng Zhao, Peng Wang, Junqiu Yue, Dongfeng Niu, Zhongwu Li, Xiaozheng Huang, Qiang Kang, Lin Jia, Jinping Lai and Dengfeng Cao

    Diagnostic Pathology 2017 12:51

    Published on: 10 July 2017

  2. Case Report

    A rare case of malignant solitary fibrous tumor in prostate with review of the literature

    Solitary fibrous tumor is an uncommon soft tissue neoplasm with intermediate biological behavior, which rarely metastasizes. Malignant solitary fibrous tumor, although not clearly defined, is rarely described ...

    Andrea Ronchi, Elvira La Mantia, Vincenzo Gigantino, Sisto Perdonà, Marco De Sio, Gaetano Facchini, Renato Franco and Annarosaria De Chiara

    Diagnostic Pathology 2017 12:50

    Published on: 7 July 2017

  3. Research

    Identification and in silico characterization of p.G380R substitution in FGFR3, associated with achondroplasia in a non-consanguineous Pakistani family

    The dimerization efficiency of FGFR3 transmembrane domain plays a critical role in the formation of a normal skeleton through the negative regulation of bone development. Recently, gain-of-function mutations i...

    Muhammad Ajmal, Asif Mir, Muhammad Shoaib, Salman Akbar Malik and Muhammad Nasir

    Diagnostic Pathology 2017 12:47

    Published on: 5 July 2017

  4. Research

    HNF4A expression as a potential diagnostic tool to discriminate primary gastric cancer from breast cancer metastasis in a Brazilian cohort

    Among the many challenges in cancer diagnosis is the early distinction between metastatic cancer and a secondary tumor. This difficulty stems from the lack of markers that offer high sensitivity and specificit...

    Patrícia Chaves de Freitas Campos Jucá, Stephany Corrêa, Giselle Maria Vignal, Maria Theresa de Souza Accioly, Suzana Angélica Silva Lustosa, Eliana Abdelhay and Delcio Matos

    Diagnostic Pathology 2017 12:43

    Published on: 5 June 2017

  5. Research

    Tumor containing fragment number influences immunohistochemistry positive rate of HER2 in biopsy specimens of gastric cancer

    HER2 assessment in biopsy specimens of gastric cancer (GC) is challenging because of the intratumoral heterogeneity. False negative results may be get because of limited biopsy material. The aim of this study ...

    Chen Xu, Yalan Liu, Xiaowen Ge, Dongxian Jiang, Ying Zhang, Yuan Ji, Jun Hou, Jie Huang, Jieakesu Su, Haiying Zeng, Jing Qin and Yingyong Hou

    Diagnostic Pathology 2017 12:41

    Published on: 26 May 2017

  6. Case Report

    Intestinal differentiated mucinous adenocarcinoma of the endometrium with sporadic MSI high status: a case report

    Intestinal differentiation of primary mucinous adenocarcinoma of the uterine corpus is exceedingly rare in comparison to the approximately 25% rate in endocervical and ovarian mucinous carcinoma. Additionally,...

    Mafalda Trippel, Sara Imboden, Andrea Papadia, Michael D. Mueller, Nando Mertineit, Kirsi Härmä, Alina Nicolae, Erik Vassella and Tilman T. Rau

    Diagnostic Pathology 2017 12:39

    Published on: 12 May 2017

  7. Case Report

    Primary Ewing’s sarcoma/primitive neuroectodermal tumor of the ileum: case report of a 16-year-old Chinese female and literature review

    Ewing’s sarcoma (ES) and primitive neuroectodermal tumors (PNET) are closely related tumors. Although soft tissue ES/PNET are common in clinical practice, they are rare in the small intestine. Because of the a...

    Teng Li, Fang Zhang, Yarui Cao, Shoubin Ning, Yongmin Bi, Weicheng Xue and Li Ren

    Diagnostic Pathology 2017 12:37

    Published on: 4 May 2017

  8. Case Report

    Primary extragenital endometrial stromal sarcoma of the lung: first reported case and review of literature

    Endometrial stromal sarcomas arising in extrauterine and extraovarian sites, in the absence of a primary uterine lesion are quite rare, especially in the absence of endometriosis. They usually present as an ab...

    Lara Alessandrini, Francesco Sopracordevole, Giulio Bertola, Simona Scalone, Martina Urbani, Gianmaria Miolo, Tiziana Perin, Fabrizio Italia and Vincenzo Canzonieri

    Diagnostic Pathology 2017 12:36

    Published on: 2 May 2017

  9. Case Report

    Case report: ACTH-secreting pituitary carcinoma metastatic to the liver in a patient with a history of atypical pituitary adenoma and Cushing’s disease

    Pituitary carcinoma is a rare entity requiring the presence of metastasis to confirm its malignant potential. We report a case of pituitary carcinoma and discuss the diagnosis and management of this lesion in ...

    Amy S. Joehlin-Price, Douglas A. Hardesty, Christina A. Arnold, Lawrence S. Kirschner, Daniel M. Prevedello and Norman L. Lehman

    Diagnostic Pathology 2017 12:34

    Published on: 18 April 2017

  10. Review

    Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge

    Oral squamous cell carcinoma (OSCC) accounts over 90% of malignant neoplasms of the oral cavity. This pathological entity is associated to a high mortality rate that has remained unchanged over the past decade...

    Maria Noel Marzano Rodrigues Petruzzi, Karen Cherubini, Fernanda Gonçalves Salum and Maria Antonia Zancanaro de Figueiredo

    Diagnostic Pathology 2017 12:32

    Published on: 5 April 2017

  11. Research

    Targeted sequencing may facilitate differential diagnostics of pulmonary tumours: a case series

    Histopathological diagnosis is important for prognostication and choice of treatment in patients with cancer in the lung. Metastases to the lungs are common and need to be distinguished from primary lung cance...

    Kajsa Ericson-Lindquist, Anna Johansson, Per Levéen, Göran Elmberger, Göran Jönsson, Johan Staaf and Hans Brunnström

    Diagnostic Pathology 2017 12:31

    Published on: 27 March 2017

  12. Case Report

    Malignant gastrointestinal neuroectodermal tumor: a case report and review of the literature

    Malignant gastrointestinal neuroectodermal tumor (GNET) is an extremely rare entity that was first described by Zambrano et al. in 2003 as “Clear cell sarcoma-like tumor of the gastrointestinal tract”. It shar...

    Mohammed J. Alyousef, Jumana A. Alratroot, Tarek ElSharkawy, Mohamed A. Shawarby, Mohammad A. Al hamad, Tarek M. Hashem and Ahmed Alsayyah

    Diagnostic Pathology 2017 12:29

    Published on: 20 March 2017

  13. Case Report

    Cerebellar ependymoma with overlapping features of clear-cell and tanycytic variants mimicking hemangioblastoma: a case report and literature review

    Imaging and histology of clear-cell ependymoma and cerebellum-based hemangioblastoma are similar; distinguishing between them is a diagnostic challenge.

    Xiu-Peng Zhang, Yang Liu, Di Zhang, Qin Zheng, Chen Wang, Liang Wang, Qing-Chang Li, Xue-Shan Qiu and En-Hua Wang

    Diagnostic Pathology 2017 12:28

    Published on: 20 March 2017

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