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Table 4 Relationship analysis among XIAP/Smac expression, apoptosis index, clinicopathologic parameters and prognosis

From: X-linked inhibitor of apoptosis positive nuclear labeling: a new independent prognostic biomarker of breast invasive ductal carcinoma

 

n*

P value

P value

RR

95%CI

  

(Log rank)

(Cox-reg)

 

Lower

Upper

Age

     

<50

49

    

≥50

53

<0.0001

0.002

9.181

2.332~36.147

Size

     

≤5 cm

77

    

>5 cm

25

0.006

0.065

2.903

0.935~9.016

LN status

     

N0

39

    

N1-3

63

<0.0001

0.012

14.757

1.803~120.750

Grade

     

I

25

    

II-III

77

0.596

0.391

0.555

0.144~2.134

XIAP-C

     

<2

16

    

≥2

86

0.153

0.188

0.398

0.101~1.568

XIAP-N

     

positive

44

    

negative

58

0.039

0.043

3.027

1.033~8.869

Smac

     

<2

68

    

≥2

34

0.595

0.395

0.634

0.222~1.809

ER

     

positive

39

    

negative

63

0.965

0.774

1.181

0.379~3.681

PR

     

positive

44

    

negative

58

0.861

0.779

1.177

0.378~3.662

HER2

     

<2

31

    

≥2

71

0.182

0.082

3.522

0.853~14.538

AI

     

<1.32

65

    

≥1.32

37

0.648

0.658

1.244

0.474~3.264

  1. n*: number of cases. RR: relative risk. CI: confidence interval. LN: lymph node. AI: apoptosis index. XIAP-C and XIAP-N denoted cytoplasmic immune staining score and nuclear labeling of XIAP, respectively. P-values (two sided) < 0.05 were highlighted in bold.
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Diagnostic Pathology

ISSN: 1746-1596

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