LMP1 and LMP2A are potential prognostic markers of extranodal NK/T-cell lymphoma, nasal type (ENKTL)

Diagnostic Pathology

Table 1 Clinical and histologic features of 16 patients with ENKTL

Patient no.	Age	Sex	Primary sites	Ann Arbor stage	LDH level	B symptoms	IPI	Therapy	Response to treatment	LMP1 expression (IHS)	LMP2A expression (IHS)
1	36	M	Nasal cavity	II	Normal	Positive	LI	CHOP + FLAG	PR	6	6
2	36	M	Oropharynx	III	High	Positive	HI	CHOP	PR	4	2
3	57	M	Nasal cavity	II	Normal	Negative	HI	Surgery + CHOP	CR	2	1
4	55	M	Larynx	I	Normal	Positive	LI	Surgery + CHOP	PR	8	1
5	49	F	Nasal cavity	II	High	Negative	L	Surgery	NR	1	4
6	51	M	Nasal cavity	I	High	Negative	LI	CHOP + Radiotherapy	PR	2	1
7	67	M	Nasal cavity	II	Normal	Positive	HI	CHOP + GDP + CVAD	CR	9	4
8	25	M	Oropharynx, palate	II	Normal	Negative	L	CHOPE + ICE + Radiotherapy	CR	1	9
9	71	M	Nasal cavity	I	High	Positive	LI	CHOP + SMILE	CR	4	2
10	36	M	Nasal cavity	II	Normal	Negative	L	CHOP	PR	6	1
11	63	M	Nasal cavity	I	Normal	Negative	L	CEVP + Radiotherapy	PR	2	1
12	56	M	Nasal cavity	II	Normal	Positive	LI	Surgery + CHOP	PR	3	2
13	66	F	Larynx	II	High	Positive	HI	Surgery	CR	6	8
14	47	M	Nasopharynx	I	Normal	Negative	L	VEPA + Radiotherapy	CR	8	1
15	51	F	Nasal cavity	III	Normal	Positive	HI	DICE + SMILE	PR	9	9
16	27	M	Nasal cavity	II	Normal	Negative	LI	Surgery + CHOP	CR	3	6

LDH: lactate dehydrogenase; IPI: international prognostic index; IHS: immunohistochemistry score; LMP1: latent membrane protein 1; LMP2A: latent membrane protein 2A; L: low risk; LI: low-intermiediate risk; HI: high-intermiediate risk; CR: complete remission; PR: partial remission; NR: no response; CHOP: cyclophosphamide, hydroxydaunomycin, oncovin, prednisone; FLAG: fludarabine, arabinosylcytosine, granulocyte colony-stimulating factor; GDP: gemcitabine, dexamethasone, cisplatin; CVAD: cyclophosphamide, vindesine sulfate, adriamycin, cisplatin; CHOPE: cyclophosphamide, hydroxydaunomycin, oncovin, prednisone, etoposide; ICE: ifosfamide, cisplatin, etoposide; SMILE: steroid, methotrexate, ifosfamide, l-asparaginase, etoposide; CEVP: cyclophosphamide, epirubicin, vincristine, prednisone; VEPA: vincristine, cyclophosphamide, doxorubicin, predonisolone; DICE: dexamethasone, ifosfamide, cisplatin, etoposide.

ISSN: 1746-1596