Genomic amplification patterns of human telomerase RNA gene and C-MYC in liquid-based cytological specimens used for the detection of high-grade cervical intraepithelial neoplasia

Table 2 TERC and C-MYC positivity rates for various histological diagnoses

Histological diagnosis	Case no.	TERC positive			C-MYC positive
		Case no.	%	P	Case no.	%	P
Normal	164	15	9.2		34	20.7
CIN1†	29	5	17.2		9	31.0
CIN2	21	16	76.2		15	71.4
CIN3	22	22	100.0		18	81.8
SCC	7	7	100.0		7	100.0
Normal vs. CIN1		> 0.05			> 0.05
CIN1 vs. CIN2+		< 0.01*			< 0.01*
Normal/CIN1 vs. CIN2+		< 0.01*			< 0.01*

† CIN1 includes lesions previously classified as mild dysplasia, koilocytotic atypia, koilocytosis and flat condyloma
* P < 0.05: statistically significant difference between 2 categories

ISSN: 1746-1596