| Reader A | Reader B | Reader C | |||
---|---|---|---|---|---|---|
 | Gene-protein BISH (N = 183) | Single BISH (N = 183) | Gene-protein BISH (N = 183) | Single BISH (N = 183) | Gene-protein BISH (N = 183) | Single BISH (N = 183) |
HER2 mean | ||||||
n | 179 | 166 | 179 | 172 | 180 | 173 |
Mean (SD) | 4.273 (4.208) | 4.643 (4.567) | 5.199 (6.280) | 5.452 (6.693) | 3.333 (2.851) | 3.176 (2.362) |
Median | 2.200 | 2.225 | 1.900 | 1.900 | 2.000 | 1.950 |
Min, max | 1.00, 21.10 | 1.00, 22.60 | 1.00, 40.20 | 1.00, 40.40 | 1.00, 16.25 | 1.20, 11.10 |
CEN17 mean | ||||||
n | 179 | 166 | 179 | 172 | 180 | 173 |
Mean (SD) | 1.803 (0.496) | 1.868 (0.501) | 1.566 (0.356) | 1.540 (0.339) | 1.606 (0.335) | 1.613 (0.296) |
Median | 1.650 | 1.750 | 1.500 | 1.450 | 1.550 | 1.550 |
Min, max | 1.00, 3.50 | 1.00, 3.95 | 1.00, 2.80 | 1.00, 2.95 | 1.05, 2.60 | 1.00, 2.65 |
HER2 /CEN17 ratio | ||||||
n | 179 | 166 | 179 | 172 | 180 | 173 |
Mean (SD) | 2.485 (2.613) | 2.521 (2.533) | 3.344 (3.952) | 3.637 (4.620) | 2.100 (1.802) | 2.004 (1.564) |
Median | 1.170 | 1.190 | 1.310 | 1.355 | 1.255 | 1.240 |
Min, max | 0.67, 10.82 | 0.76, 11.02 | 0.67, 19.14 | 0.60, 26.06 | 0.74, 8.46 | 0.82, 9.25 |
Amplification status, n (%) | ||||||
Amplified | 46 (25.1) | 46 (25.1) | 49 (26.8) | 50 (27.3) | 47 (25.7) | 43 (23.5) |
Non-amplified | 133 (72.7) | 120 (65.6) | 130 (71.0) | 122 (66.7) | 133 (72.7) | 130 (71.0) |
N/A | 4 (2.2) | 17 (9.3) | 4 (2.2) | 11 (6.0) | 3 (1.6) | 10 (5.5) |