Figure 6

Individual CN ratios of selected genes in CUSA and FFPE specimens from all four glioblastomas. A. The CN ratio values for genes with high-level amplifications (CN ratios ≥ 6.0) are shown for individual glioblastomas as indicated along the x- axis. Each gene, except for MDM2, was tested with two probe sets. B. In contrast, the CN ratio values are shown for individual genes that were unaltered within all four glioblastomas. These CN ratios remained in the normal range for all replicates and probe sets in all assays on both types of glioblastoma specimens. Note the marked difference between the ranges of y-axes for A and B. The CN ratios were calculated according to [tumor DNA] / [NB DNA] with averages in 95 % confidence intervals (bars) shown here.