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Figure 1 | Diagnostic Pathology

Figure 1

From: Inducible nitric oxide synthase expression in gastric adenocarcinoma: impact on lymphangiogenesis and lymphatic metastasis

Figure 1

iNOS immunoreactivity in gastric carcinoma tissue. (A) A focal/weak/luminal immunoreaction is observed in a well-differentiated adenocarcinoma case. (B) Intense/diffuse/cytoplasmic iNOS immunoreactivity is observed in a poorly differentiated tumor tissue. (C) No iNOS expression was detected in non-neoplastic glands in the same case. (D) Despite focal/weak iNOS immunoreactivity in well-differentiated tumor areas, there is strong iNOS expression in tumor cells of the invasive phenotype. iNOS immunoreactivity is demonstrated in endothelial cells (E) and fibroblasts (F) in the tumor stroma.

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