Table 5 CD44 expression stratified by the MYCN amplification status in relation to other histoclinical parameters of pNTs
MYCN amplified | P value | MYCN nonamplified | P value | |||
|---|---|---|---|---|---|---|
CD44 positive | CD44 negative | CD44 positive | CD44 negative | |||
No. (%) | No. (%) | No. (%) | No. (%) | |||
Age (months) | ||||||
< 18 | 1 (20) | 4 (80) | 1** | 4 (80) | 1 (20) | 1** |
≥ 18 | 2 (40) | 3 (60) | 10 (66.7) | 5 (33,3) | ||
INSS stages | ||||||
I, II, IVs | 1 (100) | 0 (0) | 0,3 | 8 (100) | 0 (0) | 0,046 |
III, IV | 2 (22.2) | 7 (77,8) | 7 (53.8) | 6 (46,2) | ||
Metastasis | ||||||
Presence | 2 (25) | 6 (75) | 1 | 6 (50) | 6 (50) | 0,019 |
Absence | 1 (50) | 1 (50) | 9 (100) | 0 (0) | ||
Differentiation level | ||||||
Undifferentiated | 3 (30) | 7 (70) | - | 5 (55.6) | 4 (44.4) | 0,33 |
Differentiated | 0 (0) | 0 (0) | 10 (83.3) | 2 (16.7) | ||
Shimada category | ||||||
Favorable histology | 1 (50) | 1 (50) | 1 | 11 (100) | 0 (0) | 0.004 |
Unfavorable histology | 2 (25) | 6 (75) | 4 (40) | 6 (60) | ||
MKI Index | ||||||
High | 1 (50) | 1 (50) | 0.645* | 5 (71,4) | 2 (28.6) | 0.262* |
Intermediate | 0 (0) | 2 (100) | 2 (50) | 2 (50) | ||
Low | 1 (25) | 3 (75) | 1 (33.3) | 2 (66.7) | ||