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Table 3 Meta-analysis of NQO1 Pro187Ser polymorphism and breast cancer risk

From: The NQO1 Pro187Ser polymorphism and breast cancer susceptibility: evidence from an updated meta-analysis

Analysis

No. of studies

Ser/Ser vs. Pro/Pro (Homozygote)

Ser/Pro vs. Pro/Pro (Heterozygote)

Ser/Ser + Ser/Pro vs. Pro/Pro (Dominant model)

Ser/Ser vs. Ser/Pro + Pro/Pro (Recessive model)

OR (95% CI)

P/P Q

OR (95% CI)

P/P Q

OR (95% CI)

P/P Q

OR (95% CI)

P/P Q

Overall

10

1.251 (0.843-1.856)

0.266/0.004

1.015 (0.860-1.198)

0.860/0.033

1.058 (0.899-1.245)

0.498/0.023

1.317 (0.919-1.887)

0.133/0.007

Ethnicity

         

Caucasian

6

1.725 (0.884-3.368)

0.110/0.003

1.145 (1.008-1.301)

0.038/0.505

1.177 (1.041-1.331)

0.009/0.358

1.654 (0.847-3.232)

0.141/0.003

Asian

3

0.785 (0.571-1.080)

0.137/0.676

0.926 (0.771-1.124)

0.309/0.225

0.941 (0.790-1.129)

0.310/0.536

1.008 (0.765-1.329)

0.955/0.195

Arab

1

1.362 (0.525-3.533)

0.526/─

1.168 (0.687-1.986)

0.565/─

1.202 (0.731-1.976)

0.469/─

1.290 (0.506-3.286)

0.594/─

Menopausal status

         

Premenopausal

2

1.124 (0.681-1.853)

0.648/0.299

1.110 (0.900-1.368)

0.330/0.431

1.104 (0.902-1.352)

0.337/0.604

1.160 (0.719-1.871)

0.544/0.147

Postmenopausal

2

0.637 (0.356-1.140)

0.129/0.833

0.950 (0.737-1.225)

0.694/0.187

0.918 (0.718-1.174)

0.495/0.113

0.762 (0.445-1.305)

0.322/0.482

Quality score

         

≥7

6

1.287 (0.746-2.221)

0.364/0.112

1.062 (0.864-1.307)

0.567/0.376

1.107 (0.897-1.365)

0.343/0.147

1.315 (0.817-2.117)

0.260/0.231

<7

4

1.251 (0.627-2.496)

0.524/0.021

0.942 (0.698-1.271)

0.694/0.070

0.983 (0.738-1.309)

0.906/0.071

1.368 (0.701-2.669)

0.358/0.015

Source of control

         

HB

4

1.099 (0.604-2.001)

0.757/0.017

0.966 (0.823-1.140)

0.311/0.301

0.912 (0.744-1.125)

0.179/0.252

1.344 (0.784-2.304)

0.283/0.015

PB

6

1.419 (0.802-2.511)

0.230/0.124

1.180 (1.035-1.344)

0.013/0.782

1.191 (1.050-1.350)

0.007/0.385

1.335 (0.767-2.323)

0.308/0.230

HWE in controls

         

Yes

8

1.450 (0.878-2.395)

0.147/0.004

1.080 (0.906-1.287)

0.389/0.069

1.136 (0.964-1.340)

0.128/0.079

1.463 (0.931-2.299)

0.099/0.011

No

2

0.791 (0.539-1.162)

0.232/0.378

0.800 (0.609-1.050)

0.108/0.389

0.788 (0.609-1.021)

0.091/0.607

0.926 (0.656-1.308)

0.663/0.105

  1. P Q P values of Q-test for heterogeneity test. OR, odds ratio; CI, confidence intervals; HB, Hospital–based studies; PB, Population-based studies; HWE, Hardy–Weinberg equilibrium.
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Diagnostic Pathology

ISSN: 1746-1596

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