From: Prognostic impact of TAZ and β-catenin expression in adenocarcinoma of the esophagogastric junction
Factors | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |
TAZ | ||||
Positive vs. Negative | 2.740 (1.791-4.192) | <0.001* | 1.879 (1.097-3.218) | 0.022* |
β-catenin (nuclear) | ||||
Positive vs. Negative | 1.572 (1.028-2.402) | 0.037* | ||
β-catenin (membranous) | ||||
Abnormal vs. Normal | 2.153 (1.377-3.367) | <0.001* | ||
TAZ & β-catenin (nuclear) | ||||
Positive vs. All others | 2.482 (1.606-3.837) | <0.001* | ||
TAZ & β-catenin (membranous) | ||||
Abnormal vs. All others | 3.458 (1.732-6.908) | <0.001* | ||
TAZ & β-catenin (nuclear and membranous) | ||||
Abnormal vs. All others | 3.330 (2.082-5.328) | <0.001* | 1.899 (1.053-3.423) | 0.033* |
Tumor size (diameter) | ||||
≥ 3 cm vs. <3 cm | 1.490 (0.886-2.506) | 0.132 | ||
Lymph node status | ||||
Positive vs. Negative | 1.548 (1.006-2.383) | 0.047* | ||
Tumor differentiation | ||||
Poorly vs. Well-differentiated | 2.165 (1.419-3.304) | <0.001* | 1.870 (1.216-2.877) | 0.004* |
Age (years) | ||||
≥ 60 vs. < 60 | 1.216 (0.782-1.890) | 0.386 | ||
Gender | ||||
Male vs. Female | 1.687 (0.918-3.102) | 0.092 | ||
Invation of serosa | ||||
Positive vs. Negative | 1.355 (0.893-2.057) | 0.154 |