Table 3 “Submucosa invasion-associated” pathologic factors in 616 validation cohorts
From: Poorly differentiated component in gastric pinch biopsies predicts submucosal invasion
Variables | Depth of invasion | P value | |
|---|---|---|---|
Submucosa (%) | Mucosa (%) | ||
WHO histologic grade | <0.0001 | ||
Well | 114 (59.1) | 322 (76.1) | |
Moderate | 34 (17.6) | 47 (11.1) | |
Poor | 45 (23.3) | 54 (12.8) | |
Poorly differentiated tumor | <0.0001 | ||
Absent | 99 (51.3) | 301 (71.2) | |
Present | 94 (48.7) | 122 (28.8) | |
Islands of muscularis mucosa | 0.0008 | ||
Absent | 160 (82.9) | 389 (92.0) | |
Present | 33 (17.1) | 34 (8.0) | |
Cribriform pattern | 0.9943 | ||
Absent | 188 (97.4) | 412 (97.4) | |
Present | 5 (2.6) | 11 (2.6) | |
Papillary architecture | 0.1327 | ||
Absent | 132 (68.4) | 314 (74.2) | |
Present | 61 (31.6) | 109 (25.8) | |
Intraglandular eosinophilic necrotic debris | 0.5814 | ||
Absent | 128 (66.3) | 290 (68.6) | |
Present | 65 (33.7) | 133 (31.4) | |
Desmoplastic reaction | 0.0934 | ||
Absent | 190 (98.4) | 422 (99.8) | |
Present | 3 (1.6) | 1 (0.2) | |
Total numbers | 193 | 423 | |