Table 1 Standardized vs non-standardized protocol: Characteristics of 175 re-evaluated periampullary adenocarcinomas
NSP | SP | p-value | All | |
|---|---|---|---|---|
(n = 129) | (n = 46) | (n = 175) | ||
Tumour origin | 0.040 | |||
Duodenum | 9 (7%) | 5 (11%) | 14 (8%) | |
Ampulla, both types | 58 (45%) | 12 (26%) | 70 (40%) | |
Distal Bile Duct | 27 (21%) | 18 (39%) | 45 (26%) | |
Pancreas | 35 (27%) | 11 (24%) | 46 (26%) | |
Tumour size, mm | ||||
M (IQR) | 30 (20–35) | 30 (25–40) | 0.649 | 30 (21–35) |
Larger than 20 mm | 92 (71%) | 42 (91%) | 0.008 | 134 (77%) |
Differentiation, poor | 70 (54%) | 31 (67%) | 0.164 | 101 (58%) |
Lymph nodes | ||||
In PD specimen, M (IQR) | 6 (3–10) | 9 (7–13) | 0.102 | 7 (4–10) |
From PD specimens, M (IQR) | 1 (0–2) | 7 (3–9) | <0.001 | 2 (0–5) |
Total PD specimen, M (IQR) | 8 (5–12) | 16 (12–19) | <0.001 | 11 (6–15) |
≥10 lymph nodes PD specimen, n (%) | 58 (45%) | 40 (87%) | <0.001 | 98 (56%) |
Other local lymph nodes, M (IQR) | 0 (0–1) | 0 (0–1) | 0.400 | 0 (0–1) |
Total, all lymph nodes, M (IQR) | 9 (5–13) | 16 (13–20) | <0.001 | 11 (6–16) |
Involved lymph nodes | ||||
In PD specimen, M (IQR) | 1 (0–2) | 3 (0–4) | 0.001 | 1 (0–3) |
From PD specimen, M (IQR) | 0 (0–0) | 0 (0–1) | 0.024 | 0 (0–0) |
Total PD specimen, M (IQR) | 1 (0–2) | 3 (0–4) | 0.023 | 1 (0–3) |
Other local, M (IQR) | 0 (0–0) | 0 (0–0) | 0.017 | 0 (0–0) |
Total, all involved lymph nodes, M (IQR) | 1 (0–2) | 3 (0–4) | 0.015 | 1 (0–3) |
N-stage, pN1 (for duodenum pN1-N2) | 74 (57%) | 33 (72%) | 0.113 | 107 (61%) |
Margin involvement | <0.001 | |||
R1 | 60 (47%) | 34 (74%) | 94 (54%) | |
Rx (uncertain/unassessable) | 56 (43%) | 0 (0%) | 56 (32%) | |
R0 | 13 (10%) | 12 (26%) | 25 (14%) | |
Perineural infiltration | 71 (55%) | 34 (74%) | 0.035 | 105 (60%) |
Infiltration in lymph vessels | 79 (61%) | 32 (70%) | 0.374 | 111 (63%) |
Infiltration in blood vessels | 38 (29%) | 4 (9%) | 0.004 | 42 (24%) |
Infiltration in peripancreatic fat | 71 (55%) | 36 (78%) | 0.008 | 107 (61%) |
T-stage | 0.074 | |||
pT1 | 8 (6%) | 0 (0%) | 8 (4%) | |
pT2 | 21 (17%) | 3 (6%) | 24 (14%) | |
pT3 | 70 (54%) | 33 (72%) | 103 (59%) | |
pT4 | 30 (23%) | 10 (22%) | 40 (23%) | |
Blocks from PD-specimen | ||||
Regular blocks, Median (IQR) | 15 (12–22) | 23 (20–27) | 0.001 | |
Mean (min - max) | 17 (6–48) | 24 (14–36) | ||
Large blocks, Median (IQR) | 0 (0–2) | 0 (0–0) | <0.001 | |
Mean (min - max) | 1 (0–8) | 0 (0–0) |