Fig. 2
From: Adenocarcinoma of the cervix involving the fallopian tube mucosa: report of a case
Staining pattern of the tubal metastasis. The higher power image of the tubal lesion, hematoxylin and eosin (400x, original magnification). Immunohistochemical stains of the tubal tumor show the contrast with the normal tubal tissue. p16 is strongly diffusely positive in the tumor unlike the normal mucosa (400x, original magnification); p53 shows a wild type pattern similar to the normal mucosa (400x, original magnification); Estrogen receptor (ER) is negative in the tumor tissue in contrast to the normal (400x, original magnification). This pattern contrasts with the expected pattern for high grade serous carcinoma arising in the fallopian tube which would typically show positive staining for ER and p53 (mutated)