Table 1 Specificity/sensitivity/positive predictive value and negative predictive value for each transcript as detected by digital RNA quantification
No (n) | Result (Pos./ Neg.) | Sensitivity (%) | Specificity (%) | PPVa (%) | NPVb (%) | |
|---|---|---|---|---|---|---|
Acute Myeloid Leukemia (AML) | ||||||
AML1-ETO | 8 | 8/0 | 100 | 100 | 100 | 100 |
PML-RARA | 8 | 8/0 | 100 | 100 | 100 | 100 |
CBFB-MYH11 | 7 | 4/3 | 57 | 100 | 100 | 97 |
Acute Lymphoblastic Leukemia (ALL) | ||||||
TCF3-PBX1 | 4 | 3/1 | 75 | 100 | 100 | 99 |
MLL-AF4 | 7 | 6/1 | 85 | 100 | 100 | 99 |
BCR-ABL | 7 | 7/0 | 100 | 100 | 100 | 100 |
ETV6-RUNX1 | 8 | 1/7 | 12 | 92 | 50 | 92 |
AML - Normal Karyotype | 19 | 0/19 | N/A | 100 | N/A | 100 |
AML - Complex Karyotype | 21 | 1/20 | N/A | 99 | N/A | 100 |
Normal Bone Marrow | 5 | 0/5 | N/A | 100 | N/A | 100 |