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Table 3 Differential diagnosis by immunohistochemistry of GCE with other tumors that may have giant cells

From: Immunohistochemical features of giant cell ependymoma of the filum terminale with unusual clinical and radiological presentation

Marker

GCE

Paraganglioma

MPNST

Metastatic melanoma

Adrenal carcinoma

Urothelial carcinoma

S-100 protein

+

+

+/-

+/-

-

-

GFAP

+

-

-

-

-

-

CD56

+

+

-

-

-

-

CD99

+

-

-

-

-

-

Bcl-2

+

-

-

-

-

-

Cyclin D1

+

-

-

-

-

-

Inhibin

-

-

-

-

+

-

HMB45

-

-

-

+

-

-

Melan A

-

-

-

+

-

-

Chromogranin

-

+

-

-

-

-

Synaptophysin

-

+

-

-

-

-

CKAE1/AE3

-

-

-

-

+

-

EMA

+/-

-

-

-

+

-

CK20

-

-

-

-

-

+

Uroplakin III

-

-

-

-

-

+

GATA3

-

-

-

-

-

+

PAX5

-

-

-

-

-

+

  1. CK cytokeratin, EMA epithelial membrane antigen,GFAP Glial fibrillary acidic protein
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Diagnostic Pathology

ISSN: 1746-1596

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