Fig. 7From: Cytokeratin7 and cytokeratin19 expression in high grade cervical intraepithelial neoplasm and squamous cell carcinoma and their possible association in cervical carcinogenesisExpression pattern of CK7, CK19, p16, and HR HPV in squamous cell carcinoma (SCC). HE staining shows SCC with solid tumor nests (SCC#8) (a), SCC with cystic change (SCC#19) (b), and SCC with glandular differentiation (SCC#29) (c). CK7 staining is negative in SCC#8 (d) and diffusely positive in SCC#19 (e) and SCC#29 (f). CK19 staining pattern is patchy in SCC#8 (g) and SCC#19 (h), and diffuse in SCC#29 (i). p16 staining is diffusely positive with variable intensity in SCC#8 (j), SCC#19 (k), and SCC#29 (l). HPV is present in mixture of episomal and integrated form in SCC#8 (m) and predominant episomal form in the cystic tumor nest and cellular debris shedding within the cystic space of SCC#19 (n), and integrated form in SCC#29 (o). Original magnifications: (a), (c), (d), (f), (g), (i), (j), (l), (m), and (o) x400; (b), (e), (h), (k) and (n) x200Back to article page