Table 3 Cases with positive FISH
From: “Evaluation of ROS1 expression and rearrangements in a large cohort of early-stage lung cancer”
Case | FISH signals (%) | IHC H-score TMA/Fullslide | IHC heterogeneity | DNA-NGS | RNA-NGS | Histology | pStage | Age/ sex | Smoking status/ Pack-year | |
|---|---|---|---|---|---|---|---|---|---|---|
D4D6 | SP384 | |||||||||
1 | 39 | 240/300 | 300/300 | No | TP53 AKT2 CNV | ROS1-CD74 | Adenocarcinoma (mucinous component) | IIb | 75.1/male | Former smoker/12.3 |
2 | 28 | 0/0 | 0/0 | No | Fail | Fail | Squamous carcinoma | IIIa | 69.4/male | Former smoker/34.5 |
3 | 16 | 0/0 | 0/0 | No | Fail | Negative | Adenosquamous | IIb | 58.1/female | Current smoker/55 |
4 | 64 | 300/300 | 300/300 | No | SETD2, TSC2, TP53 | ROS1-CD74 | Adenocarcinoma (Solid) | IIIa | 61.6/female | Never smoker/0 |
5 | 53 | 200/300 | 200/300 | No | PTCH1, TP53 | ROS1-CD74 | Adenocarcinom (mucinous component) | IIb | 61.7/female | Current smoker/23.5 |