Fig. 2

Representative images of gastric cancer with distinct EBV-positive and -negative tumor area. Loupe view of hematoxylin and eosin staining image (A) and EBER in situ hybridization result (B). At high magnification, (C) the EBV-positive tumor area shows less differentiated histology with increased lymphocytic infiltration, and (D) the EBV-negative tumor area shows conventional tubular adenocarcinoma histology with lesser degree of lymphocytic infiltration. (E) and (F) are EBER in situ hybridization results that correspond to (C) and (D), respectively. Original magnifications: (C)–(F): ×100