Table 1 Clinicopathologic and molecular features of EWSR1 rearrangement in pulmonary hyalinizing clear cell carcinoma (N = 24)
No. | References | Age | Sex | Site | LN status | Treatment | Outcome | Molecular Testing |
|---|---|---|---|---|---|---|---|---|
1 | Doxtader et al. [12] | 55 | F | trachea | (-) | Resection with radiation therapy | 12 months, alive with no recurrence | EWSR1 rearrangement |
2 | Shah et al. [13] | 32 | M | bronchi | (-) | Resection | 18 months, alive with no recurrence | EWSR1 rearrangement |
3 | Shah et al. [13] | 39 | M | bronchi | (-) | Resection | 18 months, alive with no recurrence | EWSR1 rearrangement |
4 | Garcia et al. [14] | 38 | M | bronchi | NA | Resection | 10 months, alive with no recurrence | EWSR1-ATF1 fusion |
5 | Wang et al. [15] | 53 | M | bronchi | (+) | Resection | 192 months, lung metastasis | EWSR1-ATF1 fusion |
6 | Jeffus et al. [8] | 54 | F | bronchi | (-) | Resection | 16 months, alive with no recurrence | EWSR1-ATF1 fusion |
7 | Shahi et al. [16] | 55 | M | bronchi | (-) | Resection | 20 months, alive with no recurrence | EWSR1 rearrangement |
8 | Takamatsu et al. [9] | 52 | F | bronchi | NA | Resection | 181 months, alive with no recurrence | EWSR1-ATF1 fusion |
9 | Takamatsu et al. [9] | 35 | F | bronchi | (-) | Resection | 79 months, alive with no recurrence | EWSR1-ATF1 fusion |
10 | Takamatsu et al. [9] | 56 | F | bronchi | (+) | Resection | 12 months, alive with no recurrence | EWSR1-ATF1 fusion |
11 | Icard et al. [17] | 66 | F | trachea | NA | Laser therapy and cryotherapy | NA | EWSR rearrangement |
12 | Komatsu et al. [18] | 56 | M | LP | (-) | Resection | 6 months, alive with no recurrence | EWSR1-CREM fusion |
13 | Gubbiotti et al. [10] | 46 | F | trachea | (-) | Resection and chemoradiation | relapse after 4 years, death after 6 years | EWSR1-ATF1 fusion |
14 | Wang et al. [19] | 57 | F | bronchi | (+) | Resection | 3 months, alive with no recurrence | EWSR1-ATF1 fusion |
15–22 | Xue et al. [20] | average: 58 (range: 43–64) | 3 M; 5 F | trachea and bronchi | (+):1/8; (-):7/8 | Resection | 6–45 months, alive with no recurrence (7/7) | EWSR1 rearrangement |
23 | Chapman et al. [21] | 75 | F | LP | (-) | Resection | 8 months, alive with no recurrence | EWSR1 rearrangement |
24 | Present case | 81 | M | bronchi | (+) | Resection | 9 months, alive with no recurrence | EWSR1-ATF1 fusion |