Fig. 3

Gross and histological features of renal and liver malakoplakia. A A sallow, solid mass (red arrow) is evident in the kidney cortex (red triangle). It is invading the perirenal adipose tissue and is adherent to part of the liver (red star). B Clear boundary between the mass and the surrounding renal tissue, forming a thick fibrous pseudocapsule (H&E, magnification × 50). C Histocytes and von Hansemann cells distributed in sheets, with poor intercellular adhesion, abundant cytoplasm, eosinophilic and perivascular infiltration of lymphocytes, plasma cells, and neutrophils (H&E, magnification × 100). D Circular M-G bodies in the intracellular and extracellular interstitium, showing annular lamellar bodies with a bull’s eye or hawk’s eye appearance (H&E, magnification × 600). E Histiocytes showing diffuse cytoplasmic CD68 staining (magnification × 100). F Histiocytes showing diffuse cytoplasmic CD163 staining (magnification × 100)