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Fig. 3 | Diagnostic Pathology

Fig. 3

From: The multi-omics analyses of acsl1 reveal its translational significance as a tumor microenvironmental and prognostic biomarker in clear cell renal cell carcinoma

Fig. 3

DNA methylation modification was associated with ACSL1 silence. (A) Changes of 8 DNA methylation-associated genes between ACSL1-low and ACSL1-high expression subgroups in ccRCC. Correlation of ACSL1 mRNA expression with TET2, TET3, TRDMT1 on the right. *P < 0.05; **P < 0.01; ***P < 0.001; -, not significant. (B) Comparison of DNA methylation probes between healthy and tumorous samples: cg03498175 (ACSL1) and cg08823975 (ACSL1) exhibited higher methylation levels in tumor tissues, P < 0.0001. (C) A waterfall plot of the methylation level of the ACSL1 subregions in ccRCC is presented. The association between methylation levels of different ACSL1 probes with expression and survival were analyzed

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Diagnostic Pathology

ISSN: 1746-1596

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