Clinical and Laboratory Parameters | Patient at time of Hospital admission | Laboratory Normal Range | WHO-HAEM5bv HLH Diagnostic Criteria* |
---|---|---|---|
Body Temperature | 39.0 C | > 38.5 C | |
Spleen Size | 18 cm | > 3 cm below costal margin | |
Automated Complete Blood Count (CBC) Hemoglobin (Hgb) Absolute neutrophils (Abs neut’s) Platelets (Plt) | 11.2 g/dL 2.26 k/µL 67 k/µL | 12.0-15.6 g/dL 1.5–7.7 k/µL 150–370 l/µL | Cytopenias in > 2 cell lines as below** Hgb < 9gm/dL Abs Neut’s < 0.1k/µL Plt < 100,000/µL |
Hemophagocytosis identified on tissue Smears or sections | Identified in lymph node sections | Present | |
NK Cell Activity | 1.3% | 81–100%*** | Low |
Serum Ferritin | 1369.24 ng/ml | 4.6–204 ng/ml | > 500 ng/ml |
CD25 level (soluble interleukin) | NA | NA | > 2.0 mMol/L |
Fasting serum Triglyceride Fibrinogen | 2.43 mMol/L 134 g/dL | < 1.7 mMol/L 200–400 g/dL | Triglyceride > 2.0 mMol/L or Fibrinogen < 150 mg/dL |