Major criteria |
1. BCCs before 20 years of age or excessive numbers of BCCs out of proportion to prior sun exposure and skin type |
2. KCOTs before 20 years of age |
3. Palmar or plantar pits |
4. Lamellar calcification of the falx cerebri |
5. Medulloblastoma, typically desmoplastic |
6. First degree relative with NBCCS |
Minor criteria |
1. Rib abnormalities |
2. Other specific skeletal malformations and radiologic changes (i.e., vertebral anomalies, kyphoscoliosis, short fourth metacarpals, postaxial polydactyly) |
3. Macrocephaly |
4. Cleft lip or palate |
5. Ovarian or cardiac fibroma |
6. Lymphomesenteric cysts |
7. Ocular abnormalities (i.e., strabismus, hypertelorism, congenital cataracts, glaucoma, coloboma) |