Table 2 Correlation between Cyclin D1 and P21 expression in primary PTC lesions and clinicopathological variables
From: Clinical value of Cyclin D1 and P21 in the differential diagnosis of papillary thyroid carcinoma
Clinicopathological factors | n | Cyclin D1 expression(%) | P21 expression(%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Negative | Intermediate | High | χ2 | P-value | Negative | Intermediate | High | χ2 | P-value | ||
Gender | 3.075 | 0.215 | 1.968 | 0.374 | |||||||
Male | 56 | 3(5.36) | 10(17.86) | 43(76.78) | 4(7.14) | 28(50.00) | 24(42.86) | ||||
Female | 144 | 11(7.64) | 41(28.47) | 92(63.89) | 19(13.19) | 60(41.67) | 65(45.14) | ||||
Age (years) | 0.366 | 0.833 | 1.970 | 0.373 | |||||||
< 55 | 166 | 12(7.23) | 41(24.70) | 113(68.07) | 21(12.65) | 70(42.17) | 75(45.18) | ||||
≥ 55 | 34 | 2(5.88) | 10(29.41) | 22(64.71) | 2(5.88) | 18(52.94) | 14(41.18) | ||||
Primary tumor size (cm) | -a | 0.000 | 41.014 | 0.000 | |||||||
< 0.5 | 14 | 3(21.43) | 7(50.00) | 4(28.57) | 4(28.57) | 8(57.14) | 2(14.29) | ||||
≥ 0.5, ≤ 1 | 92 | 8(8.69) | 33(35.87) | 51(55.43) | 15(16.30) | 53(57.61) | 24(26.09) | ||||
> 1, ≤ 2 | 69 | 3(4.35) | 9(13.04) | 57(82.61) | 4(5.80) | 21(30.43) | 44(63.77) | ||||
> 2 | 25 | 0(0.00) | 2(8.00) | 23(92.00) | 0(0.00) | 6(24.00) | 19(76.00) | ||||
Number of tumors | 2.232 | 0.328 | 0.296 | 0.862 | |||||||
Single | 138 | 12(8.70) | 36(26.09) | 90(65.22) | 17(12.32) | 60(43.48) | 61(44.20) | ||||
multiple | 62 | 2(3.23) | 15(24.19) | 45(72.81) | 6(9.68) | 28(45.16) | 28(45.16) | ||||
Histological subtype | -a | 0.104 | 4.429 | 0.109 | |||||||
Classic | 185 | 14(7.57) | 44(23.78) | 127(68.65) | 19(10.27) | 81(43.78) | 85(45.95) | ||||
Follicular variant | 15 | 0(0.00) | 7(46.67) | 8(53.33) | 4(26.67) | 7(46.67) | 4(26.67) | ||||
Chronic lymphocytic thyroiditis | 0.372 | 0.830 | 0.950 | 0.622 | |||||||
Absent | 159 | 12(7.55) | 40(25.16) | 107(67.30) | 19(11.95) | 72(45.28) | 68(42.77) | ||||
Present | 41 | 2(4.88) | 11(26.83) | 28(68.29) | 4(9.76) | 16(39.02) | 21(51.22) | ||||
Lymph node metastasis | 22.764 | 0.000 | 8.266 | 0.016 | |||||||
Absent | 83 | 7(8.43) | 35(42.17) | 41(49.40) | 12(14.46) | 44(53.01) | 27(32.53) | ||||
Present | 117 | 7(5.98) | 16(13.68) | 94(80.34) | 11(9.40) | 44(37.61) | 62(52.99) | ||||
TNM | -a | 0.080 | -a | 0.353 | |||||||
I + II | 196 | 13(6.63) | 50(25.51) | 133(67.86) | 23(11.73) | 85(43.37) | 88(44.90) | ||||
III + IV | 4 | 0(0.00) | 3(75.00) | 1(25.00) | 1(25.00) | 1(25.00) | 2(50.00) | ||||