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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Validation and interpretation of Pan-TRK immunohistochemistry: a practical approach and challenges with interpretation

Fig. 2

Cases with various NTRK gene alterations. A, Representative H&E image of malignant peripheral nerve sheath tumor (MPNST). B, Strong membranous staining in a MPSNT harboring TPM4-NTRK3 fusion (Original magnification × 200, inset × 400). C-D, High grade ovarian serous carcinoma with focal punctate staining in areas with a microcystic pattern. This case revealed a NTRK1 truncation at intron 2 on NGS testing (Original magnification × 200, inset × 400)

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Diagnostic Pathology

ISSN: 1746-1596

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