Table 4 Malignancies with Negative (n = 24) Internal (in-house) results Pan-TRK IHC expression and NTRK results
Tumor location | Tumor diagnosis | NTRK analysis | Pan-TRK IHC Reference lab | Pan-TRK IHC In-house |
|---|---|---|---|---|
Breast (n = 1) | Invasive carcinoma, exclude secretory carcinoma | ETV6-NTRK3 FISH negative | - | Negative |
Lung (n = 1) | BRG-1 deficient tumor | - | Negative | Negative |
Lung (n = 7) | Pulmonary adenocarcinoma | - | Negative | Negative |
Pericardial fluid (n = 1) | Pulmonary adenocarcinoma | - | Negative | Negative |
Lymph node (n = 1) | Adenocarcinoma with Neuroendocrine differentiation | - | Negative | Negative |
Lymph node (n = 2) | Pulmonary adenocarcinoma | - | Negative | Negative |
Lung (n = 1) | Colorectal adenocarcinoma | - | Negative | Negative |
Bone (n = 1) | Poorly differentiated carcinoma | - | Negative | Negative |
Bone (n = 1) | Pulmonary Adenocarcinoma | - | Negative | Negative |
Soft tissue (n = 1) | Pulmonary mucinous adenocarcinoma | - | Negative | Negative |
Lymph node (n = 1) | Pulmonary adenocarcinoma | - | Negative | Negative |
Lymph node (n = 1) | Urothelial adenocarcinoma | - | Negative | Negative |
Lung (n = 1) | Adenocarcinoma, unknown origin | - | Negative | Negative |
Pleural fluid (n = 2) | Pulmonary adenocarcinoma | - | Negative | Negative |
Lung, FNA (n = 1) | Pulmonary adenocarcinoma | - | Equivocal (focal) | Negative |
Lung (n = 1) | Adenocarcinoma, Meningothelial-like nodule | Negative for NTRK1-3 fusion by NGS | Positive | Negative |