Table 1 Prostein immunostaining in human tumors
Prostein immunostaining result | |||||||
|---|---|---|---|---|---|---|---|
Tumor entity | on TMA (n) | analyzable (n) | negative (%) | weak (%) | moderate (%) | strong (%) | |
Tumors of the skin | Pilomatricoma | 35 | 35 | 94.3 | 2.9 | 2.9 | 0.0 |
Basal cell carcinoma | 89 | 58 | 100.0 | 0.0 | 0.0 | 0.0 | |
Benign nevus | 29 | 25 | 100.0 | 0.0 | 0.0 | 0.0 | |
Squamous cell carcinoma of the skin | 145 | 129 | 99.2 | 0.8 | 0.0 | 0.0 | |
Malignant melanoma | 65 | 61 | 100.0 | 0.0 | 0.0 | 0.0 | |
Malignant melanoma lymph node metastasis | 86 | 73 | 100.0 | 0.0 | 0.0 | 0.0 | |
Merkel cell carcinoma | 48 | 48 | 100.0 | 0.0 | 0.0 | 0.0 | |
Tumors of the head and neck | Squamous cell carcinoma of the larynx | 109 | 96 | 100.0 | 0.0 | 0.0 | 0.0 |
Squamous cell carcinoma of the pharynx | 60 | 51 | 96.1 | 3.9 | 0.0 | 0.0 | |
Oral squamous cell carcinoma (floor of the mouth) | 130 | 115 | 100.0 | 0.0 | 0.0 | 0.0 | |
Pleomorphic adenoma of the parotid gland | 50 | 48 | 100.0 | 0.0 | 0.0 | 0.0 | |
Warthin tumor of the parotid gland | 104 | 100 | 100.0 | 0.0 | 0.0 | 0.0 | |
Adenocarcinoma, NOS (Papillary Cystadenocarcinoma) | 14 | 10 | 80.0 | 10.0 | 10.0 | 0.0 | |
Salivary duct carcinoma | 15 | 12 | 100.0 | 0.0 | 0.0 | 0.0 | |
Acinic cell carcinoma of the salivary gland | 181 | 144 | 55.6 | 22.2 | 18.1 | 4.2 | |
Adenocarcinoma NOS of the salivary gland | 109 | 85 | 90.6 | 3.5 | 4.7 | 1.2 | |
Adenoid cystic carcinoma of the salivary gland | 180 | 113 | 100.0 | 0.0 | 0.0 | 0.0 | |
Basal cell adenocarcinoma of the salivary gland | 25 | 23 | 100.0 | 0.0 | 0.0 | 0.0 | |
Basal cell adenoma of the salivary gland | 101 | 85 | 100.0 | 0.0 | 0.0 | 0.0 | |
Epithelial-myoepithelial carcinoma of the salivary gland | 53 | 51 | 100.0 | 0.0 | 0.0 | 0.0 | |
Mucoepidermoid carcinoma of the salivary gland | 343 | 291 | 92.4 | 3.4 | 4.1 | 0.0 | |
Myoepithelial carcinoma of the salivary gland | 21 | 18 | 100.0 | 0.0 | 0.0 | 0.0 | |
Myoepithelioma of the salivary gland | 11 | 9 | 100.0 | 0.0 | 0.0 | 0.0 | |
Oncocytic carcinoma of the salivary gland | 12 | 12 | 100.0 | 0.0 | 0.0 | 0.0 | |
Polymorphous adenocarcinoma, low grade, of the salivary gland | 41 | 27 | 100.0 | 0.0 | 0.0 | 0.0 | |
Pleomorphic adenoma of the salivary gland | 53 | 40 | 100.0 | 0.0 | 0.0 | 0.0 | |
Tumors of the lung, pleura and thymus | Adenocarcinoma of the lung | 196 | 187 | 95.7 | 2.1 | 0.5 | 1.6 |
Squamous cell carcinoma of the lung | 80 | 71 | 100.0 | 0.0 | 0.0 | 0.0 | |
Small cell carcinoma of the lung | 16 | 16 | 100.0 | 0.0 | 0.0 | 0.0 | |
Mesothelioma, epithelioid | 40 | 29 | 96.6 | 3.4 | 0.0 | 0.0 | |
Mesothelioma, biphasic | 77 | 71 | 98.6 | 1.4 | 0.0 | 0.0 | |
Thymoma | 29 | 28 | 100.0 | 0.0 | 0.0 | 0.0 | |
Lung, neuroendocrine tumor (NET) | 29 | 27 | 55.6 | 14.8 | 29.6 | 0.0 | |
Tumors of the female genital tract | Squamous cell carcinoma of the vagina | 78 | 65 | 100.0 | 0.0 | 0.0 | 0.0 |
Squamous cell carcinoma of the vulva | 157 | 141 | 100.0 | 0.0 | 0.0 | 0.0 | |
Squamous cell carcinoma of the cervix | 136 | 126 | 100.0 | 0.0 | 0.0 | 0.0 | |
Adenocarcinoma of the cervix | 23 | 20 | 90.0 | 10.0 | 0.0 | 0.0 | |
Endometrioid endometrial carcinoma | 338 | 272 | 96.7 | 2.6 | 0.4 | 0.4 | |
Endometrial serous carcinoma | 86 | 62 | 95.2 | 3.2 | 0.0 | 1.6 | |
Carcinosarcoma of the uterus | 57 | 47 | 97.9 | 2.1 | 0.0 | 0.0 | |
Endometrial carcinoma, high grade, G3 | 13 | 10 | 100.0 | 0.0 | 0.0 | 0.0 | |
Endometrial clear cell carcinoma | 9 | 5 | 100.0 | 0.0 | 0.0 | 0.0 | |
Endometrioid carcinoma of the ovary | 130 | 111 | 96.4 | 3.6 | 0.0 | 0.0 | |
Serous carcinoma of the ovary | 580 | 540 | 98.3 | 1.5 | 0.2 | 0.0 | |
Mucinous carcinoma of the ovary | 101 | 86 | 73.3 | 12.8 | 14.0 | 0.0 | |
Clear cell carcinoma of the ovary | 51 | 51 | 98.0 | 2.0 | 0.0 | 0.0 | |
Carcinosarcoma of the ovary | 47 | 46 | 100.0 | 0.0 | 0.0 | 0.0 | |
Granulosa cell tumor of the ovary | 44 | 38 | 100.0 | 0.0 | 0.0 | 0.0 | |
Leydig cell tumor of the ovary | 4 | 4 | 100.0 | 0.0 | 0.0 | 0.0 | |
Sertoli cell tumor of the ovary | 1 | 1 | 100.0 | 0.0 | 0.0 | 0.0 | |
Sertoli Leydig cell tumor of the ovary | 3 | 3 | 100.0 | 0.0 | 0.0 | 0.0 | |
Steroid cell tumor of the ovary | 3 | 3 | 100.0 | 0.0 | 0.0 | 0.0 | |
Brenner tumor | 41 | 41 | 100.0 | 0.0 | 0.0 | 0.0 | |
Tumors of the breast | Invasive breast carcinoma of no special type | 1764 | 1656 | 95.5 | 3.8 | 0.7 | 0.1 |
Lobular carcinoma of the breast | 363 | 336 | 97.9 | 2.1 | 0.0 | 0.0 | |
Medullary carcinoma of the breast | 34 | 33 | 93.9 | 3.0 | 0.0 | 3.0 | |
Tubular carcinoma of the breast | 29 | 25 | 100.0 | 0.0 | 0.0 | 0.0 | |
Mucinous carcinoma of the breast | 65 | 52 | 98.1 | 1.9 | 0.0 | 0.0 | |
Phyllodes tumor of the breast | 50 | 40 | 100.0 | 0.0 | 0.0 | 0.0 | |
Tumors of the digestive system | Adenomatous polyp, low-grade dysplasia | 50 | 50 | 100.0 | 0.0 | 0.0 | 0.0 |
Adenomatous polyp, high-grade dysplasia | 50 | 50 | 100.0 | 0.0 | 0.0 | 0.0 | |
Adenocarcinoma of the colon | 2483 | 2220 | 78.8 | 17.7 | 2.9 | 0.5 | |
Gastric adenocarcinoma, diffuse type | 215 | 192 | 92.7 | 6.8 | 0.5 | 0.0 | |
Gastric adenocarcinoma, intestinal type | 215 | 203 | 85.2 | 10.3 | 4.4 | 0.0 | |
Gastric adenocarcinoma, mixed type | 62 | 62 | 85.5 | 12.9 | 1.6 | 0.0 | |
Adenocarcinoma of the esophagus | 83 | 66 | 97.0 | 3.0 | 0.0 | 0.0 | |
Squamous cell carcinoma of the esophagus | 76 | 59 | 100.0 | 0.0 | 0.0 | 0.0 | |
Squamous cell carcinoma of the anal canal | 91 | 80 | 100.0 | 0.0 | 0.0 | 0.0 | |
Cholangiocarcinoma | 58 | 56 | 96.4 | 3.6 | 0.0 | 0.0 | |
Gallbladder adenocarcinoma | 51 | 48 | 79.2 | 12.5 | 8.3 | 0.0 | |
Gallbladder Klatskin tumor | 42 | 31 | 93.5 | 6.5 | 0.0 | 0.0 | |
Hepatocellular carcinoma | 312 | 270 | 91.9 | 6.3 | 1.5 | 0.4 | |
Ductal adenocarcinoma of the pancreas | 659 | 625 | 61.3 | 28.8 | 8.0 | 1.9 | |
Pancreatic/Ampullary adenocarcinoma | 98 | 94 | 67.0 | 24.5 | 5.3 | 3.2 | |
Acinar cell carcinoma of the pancreas | 18 | 18 | 100.0 | 0.0 | 0.0 | 0.0 | |
Gastrointestinal stromal tumor (GIST) | 62 | 61 | 100.0 | 0.0 | 0.0 | 0.0 | |
Appendix, neuroendocrine tumor (NET) | 25 | 20 | 0.0 | 0.0 | 0.0 | 0.0 | |
Colorectal, neuroendocrine tumor (NET) | 12 | 11 | 100.0 | 0.0 | 0.0 | 0.0 | |
Ileum, neuroendocrine tumor (NET) | 53 | 53 | 100.0 | 0.0 | 0.0 | 0.0 | |
Pancreas, neuroendocrine tumor (NET) | 101 | 95 | 84.2 | 6.3 | 9.5 | 0.0 | |
Colorectal, neuroendocrine carcinoma (NEC) | 14 | 12 | 100.0 | 0.0 | 0.0 | 0.0 | |
Ileum, neuroendocrine carcinoma (NEC) | 8 | 8 | 100.0 | 0.0 | 0.0 | 0.0 | |
Gallbladder, neuroendocrine carcinoma (NEC) | 4 | 4 | 75.0 | 0.0 | 25.0 | 0.0 | |
Pancreas, neuroendocrine carcinoma (NEC) | 14 | 14 | 100.0 | 0.0 | 0.0 | 0.0 | |
Tumors of the urinary system | Non-invasive papillary urothelial carcinoma, pTa G2 low grade | 177 | 172 | 97.7 | 1.7 | 0.6 | 0.0 |
Non-invasive papillary urothelial carcinoma, pTa G2 high grade | 141 | 139 | 100.0 | 0.0 | 0.0 | 0.0 | |
Non-invasive papillary urothelial carcinoma, pTa G3 | 219 | 128 | 98.4 | 1.6 | 0.0 | 0.0 | |
Urothelial carcinoma, pT2-4 G3 | 735 | 630 | 96.3 | 3.0 | 0.5 | 0.2 | |
Squamous cell carcinoma of the bladder | 22 | 18 | 100.0 | 0.0 | 0.0 | 0.0 | |
Small cell neuroendocrine carcinoma of the bladder | 23 | 23 | 100.0 | 0.0 | 0.0 | 0.0 | |
Sarcomatoid urothelial carcinoma | 25 | 19 | 100.0 | 0.0 | 0.0 | 0.0 | |
Urothelial carcinoma of the kidney pelvis | 62 | 54 | 100.0 | 0.0 | 0.0 | 0.0 | |
Clear cell renal cell carcinoma | 1287 | 1135 | 99.7 | 0.3 | 0.0 | 0.0 | |
Papillary renal cell carcinoma | 368 | 325 | 96.9 | 2.2 | 0.9 | 0.0 | |
Clear cell (tubulo) papillary renal cell carcinoma | 26 | 24 | 100.0 | 0.0 | 0.0 | 0.0 | |
Chromophobe renal cell carcinoma | 170 | 149 | 100.0 | 0.0 | 0.0 | 0.0 | |
Oncocytoma | 257 | 228 | 99.6 | 0.4 | 0.0 | 0.0 | |
Tumors of the male genital organs | Adenocarcinoma of the prostate, Gleason 3 + 3 | 83 | 74 | 0.0 | 0.0 | 0.0 | 100.0 |
Adenocarcinoma of the prostate, Gleason 4 + 4 | 80 | 64 | 1.6 | 1.6 | 0.0 | 96.9 | |
Adenocarcinoma of the prostate, Gleason 5 + 5 | 85 | 74 | 2.7 | 2.7 | 9.5 | 85.1 | |
Adenocarcinoma of the prostate (recurrence) | 258 | 207 | 5.3 | 17.4 | 15.0 | 62.3 | |
Small cell neuroendocrine carcinoma of the prostate | 19 | 18 | 100.0 | 0.0 | 0.0 | 0.0 | |
Seminoma | 682 | 673 | 94.5 | 5.1 | 0.4 | 0.0 | |
Embryonal carcinoma of the testis | 54 | 49 | 100.0 | 0.0 | 0.0 | 0.0 | |
Leydig cell tumor of the testis | 31 | 23 | 100.0 | 0.0 | 0.0 | 0.0 | |
Sertoli cell tumor of the testis | 2 | 1 | 100.0 | 0.0 | 0.0 | 0.0 | |
Sex cord stromal tumor of the testis | 1 | 1 | 100.0 | 0.0 | 0.0 | 0.0 | |
Spermatocytic tumor of the testis | 1 | 1 | 100.0 | 0.0 | 0.0 | 0.0 | |
Yolk sac tumor | 53 | 45 | 100.0 | 0.0 | 0.0 | 0.0 | |
Teratoma | 53 | 45 | 100.0 | 0.0 | 0.0 | 0.0 | |
Squamous cell carcinoma of the penis | 92 | 71 | 100.0 | 0.0 | 0.0 | 0.0 | |
Tumors of endocrine organs | Adenoma of the thyroid gland | 113 | 110 | 100.0 | 0.0 | 0.0 | 0.0 |
Papillary thyroid carcinoma | 391 | 354 | 99.7 | 0.3 | 0.0 | 0.0 | |
Follicular thyroid carcinoma | 154 | 146 | 100.0 | 0.0 | 0.0 | 0.0 | |
Medullary thyroid carcinoma | 111 | 105 | 100.0 | 0.0 | 0.0 | 0.0 | |
Parathyroid gland adenoma | 43 | 32 | 100.0 | 0.0 | 0.0 | 0.0 | |
Anaplastic thyroid carcinoma | 45 | 42 | 97.6 | 2.4 | 0.0 | 0.0 | |
Adrenal cortical adenoma | 50 | 48 | 100.0 | 0.0 | 0.0 | 0.0 | |
Adrenal cortical carcinoma | 28 | 28 | 100.0 | 0.0 | 0.0 | 0.0 | |
Phaeochromocytoma | 50 | 50 | 100.0 | 0.0 | 0.0 | 0.0 | |
Tumors of haemotopoetic and lymphoid tissues | Hodgkin Lymphoma | 103 | 94 | 100.0 | 0.0 | 0.0 | 0.0 |
Small lymphocytic lymphoma, B-cell type (B-SLL/B-CLL) | 50 | 39 | 100.0 | 0.0 | 0.0 | 0.0 | |
Diffuse large B cell lymphoma (DLBCL) | 113 | 92 | 97.8 | 2.2 | 0.0 | 0.0 | |
Follicular lymphoma | 88 | 65 | 100.0 | 0.0 | 0.0 | 0.0 | |
T-cell Non Hodgkin lymphoma | 25 | 20 | 100.0 | 0.0 | 0.0 | 0.0 | |
Mantle cell lymphoma | 18 | 12 | 100.0 | 0.0 | 0.0 | 0.0 | |
Marginal zone lymphoma | 16 | 12 | 100.0 | 0.0 | 0.0 | 0.0 | |
Diffuse large B-cell lymphoma (DLBCL) in the testis | 16 | 15 | 100.0 | 0.0 | 0.0 | 0.0 | |
Burkitt lymphoma | 5 | 1 | 100.0 | 0.0 | 0.0 | 0.0 | |
Tumors of soft tissue and bone | Tendosynovial giant cell tumor | 45 | 45 | 91.1 | 8.9 | 0.0 | 0.0 |
Granular cell tumor | 53 | 47 | 97.9 | 2.1 | 0.0 | 0.0 | |
Leiomyoma | 50 | 50 | 100.0 | 0.0 | 0.0 | 0.0 | |
Leiomyosarcoma | 94 | 90 | 100.0 | 0.0 | 0.0 | 0.0 | |
Liposarcoma | 145 | 144 | 100.0 | 0.0 | 0.0 | 0.0 | |
Malignant peripheral nerve sheath tumor (MPNST) | 15 | 14 | 100.0 | 0.0 | 0.0 | 0.0 | |
Myofibrosarcoma | 26 | 26 | 100.0 | 0.0 | 0.0 | 0.0 | |
Angiosarcoma | 74 | 67 | 95.5 | 1.5 | 3.0 | 0.0 | |
Angiomyolipoma | 91 | 89 | 100.0 | 0.0 | 0.0 | 0.0 | |
Dermatofibrosarcoma protuberans | 21 | 16 | 100.0 | 0.0 | 0.0 | 0.0 | |
Ganglioneuroma | 14 | 14 | 100.0 | 0.0 | 0.0 | 0.0 | |
Kaposi sarcoma | 8 | 4 | 75.0 | 25.0 | 0.0 | 0.0 | |
Neurofibroma | 117 | 117 | 100.0 | 0.0 | 0.0 | 0.0 | |
Sarcoma, not otherwise specified (NOS) | 74 | 68 | 100.0 | 0.0 | 0.0 | 0.0 | |
Paraganglioma | 41 | 41 | 100.0 | 0.0 | 0.0 | 0.0 | |
Ewing sarcoma | 23 | 16 | 100.0 | 0.0 | 0.0 | 0.0 | |
Rhabdomyosarcoma | 7 | 6 | 100.0 | 0.0 | 0.0 | 0.0 | |
Schwannoma | 122 | 121 | 100.0 | 0.0 | 0.0 | 0.0 | |
Synovial sarcoma | 12 | 11 | 100.0 | 0.0 | 0.0 | 0.0 | |
Osteosarcoma | 44 | 41 | 100.0 | 0.0 | 0.0 | 0.0 | |
Chondrosarcoma | 40 | 38 | 100.0 | 0.0 | 0.0 | 0.0 | |
Rhabdoid tumor | 5 | 5 | 100.0 | 0.0 | 0.0 | 0.0 | |
Solitary fibrous tumor | 17 | 17 | 100.0 | 0.0 | 0.0 | 0.0 | |