Table 3 Contemporary control autopsy brain cases

Non-COVID-19 cases

1

67/F

HTN, DM, COPD, obesity, cancer

N/R

Aspirin, heparin, enoxaparin

No

5

2

34/F

SAD, acute pancreatitis, hepatic cirrhosis

Acutely

N/R

Yes

0.03

3

54/M

HTN, DM, CRD, clinical sepsis, necrotizing pneumonia

4

N/R

Yes

4

4

67/F

DM2, obesity, cancer, acute Candida albicans pneumonia

Acutely

Heparin

No

0.25

5

61/M

HTN, DM2, IHD, SAD

Acutely

Aspirin

No

0.06

6

60/F

HTN, IHD, obesity, DVT, PE, retroperitoneal abscess (Streptococcus anginosus), transverse colectomy, small bowel resection

E/P

Heparin, apixaban

Yes

3

7

47/M

HTN, IHD, obesity, atrial fibrillation; Klebsiella pneumoniae

Acutely

Heparin

Yes

0.04

8^a

64/M

HTN, DM, IHD, cancer, CRD

Acutely

Heparin

Yes

0.04

9

59/M

HTN, DM, obesity, CRD, PE

3.5

Aspirin, heparin

No

3.5

10^b

55/F

HTN, DM, IHD, SAD, hepatic cirrhosis

Acutely

N/R

Yes

9

11

71/M

HTN, COPD, GI ulcer hemorrhages; Clostridium innocuum, Bacteriodes uniformis, Lactobacillus spp.

Acutely

N/R

Yes

0.4

12^{a, c}

64/M

HTN, IHD, SSD, MDS

Acutely

Aspirin, apixaban

Yes

9

13^a

67/F

HTN, IHD, COPD, obesity, CRD, diffuse cerebral atrophy; Citrobacter braakii, Serracia marcesens, Klebsiella pneumoniae

N/R

N/R

No

13

14^a

61/M

HTN, DM2, IHD, HCV, CRD, hepatic cirrhosis, small remote cerebellar infarct

1

Aspirin, clopidogrel

Yes

1.5

15

62/F

HTN, obesity, SAD, hepatic cirrhosis, toxic epidermal necrosis, diffuse cerebral atrophy; Staphylococcus aureus

N/R

N/R

No

5

16^a

49/M

IHD, obesity, gastric necrosis, intestinal gangrene, recent globus pallidus infarcts; Enterococcus faecalis, Escherichia coli, Enterobacter cloacae complex, Bacteroides thetaiotaomicron, Clostridium sporogenes

E/P

Heparin

Yes

2

17

78/F

IHD, non-COVID ARDS, obesity, DVT, PE

4

Heparin, apixaban, enoxaparin

Yes

9.5

18

43/M

HTN, asthma, obesity, bronchial mucous plugs; Escherichia coli

Acutely

N/R

No

0.04

19^a

48/M

HTN, DM2, IHD, obesity, SAD, acute bronchopneumonia

3

Heparin, enoxaparin

No

3

20

35/F

HTN, obesity, post-partum presumptive viral meningoencephalitis, pulmonary artery saddle embolus

N/R

N/R

No

0.5

21^a

44/M

HTN, DM1, cancer, small corpus striatum resolving infarct; E. faecalis, E. faecium, E. casseliflavus, K. pneumoniae

N/R

N/R

No

7

Resolved COVID-19 cases/post-COVID survival time (mo.)

22

74/M

HTN, DM, IHD, renal failure, LUE AVF severe hemorrhage/9

N/R

N/R

No

0.03

23

76/M

HTN, IHD, atrial fibrillation, SAD, CRD/10

3

Apixaban

No

3

24

43/M

SAD, HCV, hepatic cirrhosis, CML with brain metastases/2

0.5

N/R

No

5

25

60/F

HTN, IHD, SAD, ruptured aortic aneurysm/5

N/R

Heparin

No

9

26^b

64/F

HTN, IHD, COPD, obesity, cancer/15; Staphylococcus aureus, Achromobacter xylosoxidans

None

Heparin

No

0.25

27

69/M

HTN, IHD, atrial fibrillation, obesity/10; Streptococcus agalactiae, Enterobacter cloacae complex

N/R

Enoxaparin

Yes

11