Adenoid basal lesions of the uterine cervix: evolving terminology and clinicopathological concepts

Russell, Michael J; Fadare, Oluwole

doi:10.1186/1746-1596-1-18

Diagnostic Pathology

Table 1 Previously reported cases of morphologically pure adenoid basal lesions in the English literature.

From: Adenoid basal lesions of the uterine cervix: evolving terminology and clinicopathological concepts

	Authors (reference)	No of patients	age (yrs)	Race	Presentation/pap smear findings	Gross or pelvic examination findings	Associated cervical intraepithelial dysplastic lesion	Diagnostic and/or Therapeutic measure(s)	Lymph node status	Follow-up, (months)
1	Baggish & Woodruff [24]***	1	63	white	Vaginal bleeding/NR	Atrophic vaginal mucosa; NCF	CIS	Hysterectomy/BSO	NPR	NED 156
2		1	62	black	Uterine prolapse/NR	NCF	CIS	Hysterectomy	NPR	NED 84
3		1	39	black	Abnormal pap smear	NR	CIS	Conization/Hysterectomy	NPR	NED 60
4	Baggish & Woodruff [23]	1	60	white	"incidental"/negative	NCF	None	Hysterectomy/BSO	NPR	NED 6
5	Cases 1–3	1	80	white	"incidental"/negative	NCF	None	Hysterectomy/BSO	NPR	NED 6
6		1	80	black	Lower abdominal pressure/negative	Cervical eversion	CIS	Conization/Hysterectomy/BSO	NPR	NED 6
7	Russell & Laverty [22]	1	62	NR	uterine prolapse and vaginal bleeding/"Very Atypical cells"	Cervical ulceration	None	Hysterectomy	NPR	NR
8	Daroca & Dhurandhar [25], Case 3	1	60	NR	Post menopausal bleeding	Cervical erosion	CIS	Hysterectomy/BSO	NPR	NED 12
9–13	van Dinh & Woodrhuff [21]##	5	mean 56	white 3, black 2	Vaginal bleeding n = 1, asymptomatic n = 4/moderate atypia n = 5	Cervical ulceration n = 1, NCF n = 4	CIN3 n = 3, None n = 2	dilatation and curettage n = 1, Hysterectomy +/- BSO n = 4	NPR	DOC n = 1, NED 24–144, n = 4
14	Ferry & Scully [20]	1	69	black	Abnormal pap smear n = 11, PMB n = 2	NCF n = 10, cervical induration n = 2,	CIS	Hysterectomy/BSO	NPR	NED 60
15	Cases 1–13	1	63	NR			CIS	Hysterectomy/BSO	NPR	NED 120
16		1	66	black			CIS	Cervical excision/Rad	NPR	DOC 24
17		1	75	white			CIS	Hysterectomy/BSO	NPR	NED 84
18		1	65	asian			CIS	Hysterectomy/BSO/Rad	NPR	NED 72
19		1	51	NR			CIS	Hysterectomy/BSO	NPR	NED 24
20		1	56	NR			CIS	Cervical excision	NPR	NED 72
21		1	78	white			CIS	Cervical excision	NPR	NED 72
22		1	59	white			CIS	Hysterectomy/RSO	NPR	NED 60
23		1	67	black			CIS	Hysterectomy/BSO	NPR	NED 48
24		1	57	white			CIS	Hysterectomy/BSO	NPR	NED 24
25		1	72	black			CIS	Conization	NPR	NED 29
26		1	57	NR			CIS	NR	NPR	DOC 0
27	Langlois et al [19]	1	59	NR	Asymptomatic/abnormal pap smear	NCF	CIN3	Conization, Hysterectomy	NPR	NR
28	Peterson & Neumann [18]	1	64	other	Asymptomatic/HGSIL	NR	CIN2	Conization	NPR	NR
29	Layton-Henry et al [17]	1	62	NR	Abnormal Pap smear n = 5/HGSIL, one with "possible invasion", n = 3; inconclusive n = 2	NCF	CIN	Conization, Hysterectomy, BSO, LN	Negative	NED 1
30		1	64	NR		NCF	CIN	Conization, Hysterectomy, BSO	NPR	NED 7
31		1	75	NR		NCF	CIN	Conization	NPR	NED 15
32		1	60	NR		NCF	CIN	Conization, Hysterectomy, BSO, LN	Negative	NED 26
33		1	59	NR		NCF	CIN	Conization, Hysterectomy, BSO, LN	Negative	VAIN 16
34	Powers & Frable [16]	1	79	white	Asymptomatic/SCC	AWL	CIS	Conization, Hysterectomy BSO, LN	Negative	NED 18
35		1	67	black	Presentation @/"severely atypical small cells"	NCF	None	Conization, Rad	NPR	NED 16
36–40	Jones et al [13]	1	Mean 51	white n = 5	abnormal pap n = 4, PMB n = 1	"Ulcerated, irregular indurated mass" n = 2, NCF n = 3	CIN 1 to3 (n = 5)	Hysterectomy/BSO (n = 5), Hysterectomy/BSO/LN (n = 4). One patient also received Rad	Negative	NED 26 Mean
41	Yoshida et al [14]	1	49	asian	Asymptomatic	NCF	CIN 3	Hysterectomy	NPR	NR
42–45*	Grayson et al [9] (Cases 4,5,7,8)	4	NI	black	NI	NI	NI	NI	NI	NI
46	Brainard & Hart [10]	1	91	NR	Dysuria, Night sweats/HGSIL	Focal hemorrhage	CIS	Conization	NPR	NED 4
47		1	68	NR	Asymptomatic/HGSIL	NCF	CIS	Conization, Hysterectomy, BSO, LN	Negative	NED 5
48		1	78	NR	Vaginal spotting/HGSIL	NCF	Severe dysplasia	Conization, Hysterectomy, BSO, LN	Negative	NED 15
49		1	30	NR	Asymptomatic/HGSIL	NCF	Moderate severe dysplasia	Conization, Hysterectomy, BSO, LN	Negative	NED 17
50		1	71	NR	Asymptomatic/HGSIL	NCF	CIS	Conization	NPR	NED 21
51		1	67	NR	Asymptomatic/HGSIL	NCF	Microinvasive Carcinoma##	Conization, Hysterectomy, BSO, LN	Negative	NED 28
52		1	70	NR	Dysuria, Hematuria/Negative	NCF	None	Hysterectomy	NPR	NED 30
53		1	72	NR	Asymptomatic/HGSIL	NCF	CIS	Conization, Hysterectomy	NPR	NED 70
54		1	71	NR	Asymptomatic/HGSIL	NCF	CIS	Conization, BSO, Rad, LN	Negative	NED 82
55		1	76	NR	NR/HGSIL	NCF	CIS	Hysterectomy, BSO	NPR	NED 24
56		1	70	NR	Asymptomatic/LGSIL	NCF	CIS	Hysterectomy, Rad	NPR	NED 63
57		1	83	NR	Asymptomatic/HGSIL	NCF	CIS	Conization	NPR	NED 87
58		1	35	NR	Pelvic mass@/Normal	NCF	None	Hysterectomy, BSO, LN, Chemotherapy [all@]	Negative	NED 49
59		1	57	NR	Asymptomatic/CIS	NCF	CIN	Conization	NPR	NED 5
60		1	69	NR	Asymptomatic/abnormal pap smear	NCF	None	Conization	NPR	NR
61	Senzaki et al [11]	1	69	asian	Vaginal bleeding	NCF	CIS	Hysterectomy, BSO, LN [all@]	Negative	NED 6
62	Hiroi et al [6]	1	74	asian	Vaginal bleeding	NCF	CIN 3	Hysterectomy	NPR	NR
63	Khoury et al [4]	1	79	black	Asymptomatic/HGSIL	NCF	Severe dysplasia	Hysterectomy, BSO	NPR	NR
64	Teramoto [2]	1	69	asian	Asymptomatic/HGSIL	NR	CIN3	Hysterectomy and chemotherapy@	NPR	108
65	Zamecnik & Skrivanek [1]	1	21	NR	Asymptomatic//LGSIL	NCF	CIN1-3	Conization	NPR	NED 1
66	Parwani et al [1]	1	65	NR	NR/HGSIL	NR	Microinvasive Carcinoma##	Conization, Hysterectomy, LN	Negative	NED 78

Abbreviations: NED, no evidence of disease; CIS, carcinoma in situ; LN, lymph node dissection; N/A, not applicable; PMB postmenopausal bleeding; BSO or RSO bilateral or right salpingo-oophorectomy; Rad, radiation therapy; NPR Lymph node dissection not performed or reported; NCF no gross cervical findings; DOC death from other causes; LGSIL low grade squamous intraepithelial lesion; HGSIL high grade squamous intraepithelial lesion; CIN cervical intraepithelial neoplasia. Cases in Cviko et al [8] are excluded due to lack of sufficient clincopathological information; SCC squamous cell carcinoma. **Presumes cases in Grayson et al (1997) are the same in Grayson et al (1999); AWL: acetowhite lesions. NI: information not included due to a lack of sufficient itemization in original manuscript. NA: information not available. *excludes the 4 cases in Grayson et al [9] with "divergent neoplastic epithelial differentiation"; *** follow-up as reported in [23]; @ Unrelated to cervical pathology; ## Includes the cases of microinvasive carcinoma [1,10,20], see text

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