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  1. Insulin resistance (IR) in obesity is associated with the occurrence of metabolic and cardiovascular diseases. Dipepidyl peptidase 4 (DPP4) plays a pivotal role during the development of IR, and was found to b...

    Authors: Fangxiao Cheng, Geheng Yuan, Jiao He, Yimin Shao, Junqing Zhang and Xiaohui Guo

    Citation: Diagnostic Pathology 2020 15:18

    Content type: Research

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  2. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is a standard procedure used to obtain tissue samples for diagnosis of solid retroperitoneal tumours. However, this procedure demands high technica...

    Authors: Jian-Han Lai, Hsiang-Hung Lin and Ching-Chung Lin

    Citation: Diagnostic Pathology 2020 15:17

    Content type: Research

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  3. Papillary thyroid carcinoma (PTC) is an indolent tumor that is exploding with increasing thyroid nodules (TN). Environmental carcinogens, lifestyle changes increased the incidence of thyroid carcinoma. With th...

    Authors: Hongsheng Lu, Lihong Zhang, Yuechu Dai, Yanyun Ruan, Xuequan Cao, Xiaobo Cai, Sihan Ruan and Qi Chen

    Citation: Diagnostic Pathology 2020 15:16

    Content type: Research

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  4. Primary pulmonary myxoid sarcoma (PPMS) is an extremely rare lung sarcoma that is characterized in most cases by recurrent balanced chromosomal translocation t(2;22)(q33;q12) leading to the oncogenic fusion gene

    Authors: Zhenwei Chen, Yihui Yang, Rongming Chen, Chi Sing Ng and Hongqi Shi

    Citation: Diagnostic Pathology 2020 15:15

    Content type: Case Report

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  5. To investigate the role of FOXM1, β-catenin and TCF4 in esophageal cancer (EC) and their relationship to VM (Vasculogenic Mimicry).

    Authors: Lili Cheng, Qi Wang, Xiaoying Tao, Yanzi Qin, Qiong Wu, Dafang Zheng, Damin Chai, Yong Zhang, Dongbing Lu, Hongfei Ci, Zhiwei Wang, Jia Ma, Danna Wang, Zenong Cheng, Shiwu Wu and Yisheng Tao

    Citation: Diagnostic Pathology 2020 15:14

    Content type: Research

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  6. Primary thyroid Burkitt’s lymphoma (BL) is an extremely rare and highly aggressive form of non-Hodgkin’s lymphoma; only isolated case reports are available for patients with this disease.

    Authors: Toshitetsu Hayashi, Mitsuyoshi Hirokawa, Seiji Kuma, Miyoko Higuchi, Ayana Suzuki, Risa Kanematsu, Takumi Kudo, Naomi Katsuki, Reiji Haba and Akira Miyauchi

    Citation: Diagnostic Pathology 2020 15:13

    Content type: Case Report

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  7. Squamous cell carcinoma is the most common malignant tumor of the uterine cervix with a well-documented link to infection with human papillomaviruses (HPV). According to a recent classification, there are seve...

    Authors: Jan Hrudka, Blanka Rosová and Michael J. Halaška

    Citation: Diagnostic Pathology 2020 15:12

    Content type: Case Report

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  8. Primary malignant melanoma of the lung (PML) is extremely rare. No precursor lesions of PML have been identified, and little is known about the genetic mutations associated with the disease. Typically, 15–20% ...

    Authors: Takashi Hibiya, Meiro Tanaka, Mai Matsumura, Ayako Aoki, Tadashi Ikegami, Koji Okudela, Naomi Kawano and Kenichi Ohashi

    Citation: Diagnostic Pathology 2020 15:11

    Content type: Case Report

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  9. CD68+ tumor-associated macrophages (TAM) play an important role in the progression of classical Hodgkin lymphoma (cHL). We assessed the role of CD20 and CD68 + TAM in a cohort of cHL patients from Egypt and corre...

    Authors: Osama Mohamed, Ahmed El Bastawisy, Nasr Allahlobi, Mona S. Abdellateif, Abdel Rahman N. Zekri, Sabry Shaarawy, Zeinab Korany, Marwa Mohanad and Abeer A. Bahnassy

    Citation: Diagnostic Pathology 2020 15:10

    Content type: Research

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  10. Non-surgical cytological specimens are adequate not only for accurate histological subtyping but also for molecular profiling. A modified amplification refractory mutation system polymerase chain reaction (ARM...

    Authors: Wei Wu, Ziyang Cao, Wei Zhang, Liping Zhang, Likun Hou and Chunyan Wu

    Citation: Diagnostic Pathology 2020 15:9

    Content type: Research

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  11. Gastrointestinal stromal tumors (GISTs) are the most common type of adult mesenchymal neoplasms. The events that drive GIST oncogenesis are primarily KIT or PDGFRA mutations, which lead to the susceptibility of t...

    Authors: Jun Fan, Ming Yang, Bo Huang, Zhenkao Wang, Danju Luo, Jiwei Zhang, Peng Zhang, Heshui Shi, Yan Li and Xiu Nie

    Citation: Diagnostic Pathology 2020 15:8

    Content type: Case Report

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  12. Cutaneous pilomatrical carcinosarcoma (CS) is a very rare biphasic tumor composed of admixed epithelial and mesenchymal malignant cells, with limited information on its pathogenesis. We report a case of piloma...

    Authors: Thi My Hanh Luong, Yuko Akazawa, Zhanna Mussazhanova, Katsuya Matsuda, Nozomi Ueki, Shiro Miura, Toshihide Hara, Hiroko Yokoyama and Masahiro Nakashima

    Citation: Diagnostic Pathology 2020 15:7

    Content type: Case Report

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  13. To achieve optimal outcomes, an individual approach is needed in the treatment and care of patients. The potential value of tumor mutational burden (TMB) status and/or programmed cell death ligand 1 (PD-L1) ex...

    Authors: Tina Krieger, Isobel Pearson, Judith Bell, Jim Doherty and Paul Robbins

    Citation: Diagnostic Pathology 2020 15:6

    Content type: Review

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  14. Precision medicine based on genomic analysis of germline or tumor tissue is attracting attention. However, there is no consensus on how to apply the results of genomic analysis to treatment.

    Authors: Hiroshi Hongo, Takeo Kosaka, Eriko Aimono, Hiroshi Nishihara and Mototsugu Oya

    Citation: Diagnostic Pathology 2020 15:5

    Content type: Case Report

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  15. An intravenous leiomyomatosis is a special type of uterine leiomyoma characterized by the formation of benign leiomyomatous tissue within the vascular wall. Although histologically benign, intracardiac metasta...

    Authors: Mitsutake Yano, Tomomi Katoh, Yoshie Nakajima, Shiro Iwanaga, Rei Kin, Eito Kozawa and Masanori Yasuda

    Citation: Diagnostic Pathology 2020 15:4

    Content type: Case Report

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  16. NUT midline carcinoma (NMC) is a poorly differentiated squamous cancer with a median survival at less than 7 months. NMC is resistant to conventional chemotherapies and characterized by rearrangement of the NUT g...

    Authors: Peiwei Chai, Chuandi Zhou, Renbing Jia and Yefei Wang

    Citation: Diagnostic Pathology 2020 15:2

    Content type: Case Report

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  17. FNA is a simple, safe, cost-effective and accurate diagnostic tool for the initial screening of patients with thyroid nodules. The aims of this study were to determine the diagnostic utility of FNAC performed ...

    Authors: Yanli Zhu, Yuntao Song, Guohui Xu, Zhihui Fan and Wenhao Ren

    Citation: Diagnostic Pathology 2020 15:1

    Content type: Research

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  18. Epithelioid rhabdomyosarcoma is a rare tumor that generally occurs in the bladder, the parotid gland, or the skin of the neck. We describe an unusual case of primary epithelioid rhabdomyosarcoma of the stomach...

    Authors: Yangkun Wang, Pei Guo, Zhishang Zhang, Runde Jiang and Zuguo Li

    Citation: Diagnostic Pathology 2019 14:137

    Content type: Case Report

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  19. Splenic cord capillary hemangioma is a rare benign vascular lesion classified as a splenic hamartoma. On the other hand, non-islet cell tumor hypoglycemia (NICTH) is one of the rare causes of spontaneous hypog...

    Authors: Tatsuaki Daimon, Takeo Kosaka, Minoru Horinaga, Junichi Saito, Yoshito Ueyama, Shoji Matsuzaki and Mototsugu Oya

    Citation: Diagnostic Pathology 2019 14:135

    Content type: Case Report

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  20. Protein tyrosine phosphatases (PTPs) regulate neuronal differentiation and survival, but their expression patterns and functions in human neuroblastoma (NB) are scarcely known. Here, we have investigated the f...

    Authors: Caroline E. Nunes-Xavier, Olaia Aurtenetxe, Laura Zaldumbide, Ricardo López-Almaraz, Asier Erramuzpe, Jesús M. Cortés, José I. López and Rafael Pulido

    Citation: Diagnostic Pathology 2019 14:134

    Content type: Research

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  21. Interpretation of mediastinal biopsy is often challenging even for experienced pathologists especially when a hematolymphoid neoplasm is suspected. Primary mediastinal large B-cell lymphoma (PMLBCL) and classi...

    Authors: Hyun-Jung Kim, Hee Kyung Kim, Gyeongsin Park, Soo Kee Min, Hee Jeong Cha, Hyekyung Lee, Suk Jin Choi, Hee Young Na, Ji-Young Choe and Ji Eun Kim

    Citation: Diagnostic Pathology 2019 14:133

    Content type: Research

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  22. MicroRNAs (miRNAs) have been reported to serve pivotal roles in tumorigenesis. This study sough to assess the expression and clinical significance of microRNA-1298 (miR-1298) in patients with non-small cell lu...

    Authors: Zhonghai Du, Jun Wu, Juan Wang, Yan Liang, Sensen Zhang, Zhimei Shang and Wenchao Zuo

    Citation: Diagnostic Pathology 2019 14:132

    Content type: Research

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  23. Increasing evidence indicates the utility of transbronchial lung cryobiopsy (TBLC) for the diagnosis of interstitial lung disease (ILD). However, only one study has compared TBLC and surgical lung biopsy (SLB)...

    Authors: Yoshiaki Zaizen, Yasuo Kohashi, Kishio Kuroda, Kazuhiro Tabata, Yuka Kitamura, Akira Hebisawa, Yuji Saito and Junya Fukuoka

    Citation: Diagnostic Pathology 2019 14:131

    Content type: Research

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  24. Distant metastases from follicular thyroid carcinoma are mainly hematogenous and are commonly observed in the lungs and bones. Other rare sites are the parotid gland, skin, brain, ovary, adrenal gland, kidney,...

    Authors: Taolang Li, Zhiyuan Ma, Chengli Lu, Quanzhong Zhou, Zelong Feng, Xinglong Wu, Yi Luo, Dan Li, Xiaoming Cheng and Xuemei Liu

    Citation: Diagnostic Pathology 2019 14:130

    Content type: Case Report

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  25. Large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma among adults. In some cases, DLBCL may seem similar to carcinoma cells, presenting a round, oval, or polygonal shape and clear nu...

    Authors: Wan-Ming Hu, Jie-Tian Jin, Chen-Yan Wu, Jia-Bin Lu, Li-Hong Zhang, Jing Zeng and Su-Xia Lin

    Citation: Diagnostic Pathology 2019 14:128

    Content type: Research

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  26. Follicular thyroid carcinoma (FTC) is a neoplasm that presents with a micro-follicular growth pattern and a neutrally stained cytoplasm. Seldom, FTCs display unusual morphological characteristics – but given t...

    Authors: Martin Hysek, Kenbugul Jatta, Adam Stenman, Eva Darai-Ramqvist, Jan Zedenius, Anders Höög and C. Christofer Juhlin

    Citation: Diagnostic Pathology 2019 14:127

    Content type: Case Report

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  27. Myeloid sarcoma (MS), which represents a rare malignancy that comprises of myeloid blasts occurring at extra-medullary sites, closely correlates with the onset and relapse of acute myeloid leukemia (AML) and o...

    Authors: Xilin Zhang, Peichen Huang, Zhuo Chen, Xinling Bi, Ying Wang and Jianhua Wu

    Citation: Diagnostic Pathology 2019 14:126

    Content type: Case Report

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  28. Vulvar extramammary Paget disease is a rare chronic condition, that presents with non-specific symptoms such as pruritus and eczematous lesions. Because most of these lesions are noninvasive, the distinction b...

    Authors: Walquiria Quida Salles Pereira Primo, Guttenberg Rodrigues Pereira Primo, Dunya Bachour Basilio, Karime Kalil Machado, Jesus Paula Carvalho and Filomena M. Carvalho

    Citation: Diagnostic Pathology 2019 14:125

    Content type: Case Report

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  29. In spite of the multimodal treatment used today, glioblastoma is still the most aggressive and lethal cerebral tumour. To increase survival in these patients, novel therapeutic targets must be discovered. Sign...

    Authors: Sergiu Susman, Radu Pîrlog, Daniel Leucuța, Andrei Otto Mitre, Vlad Adrian Padurean, Carmen Melincovici, Ioana Moldovan, Doinița Crișan and Stefan Ioan Florian

    Citation: Diagnostic Pathology 2019 14:124

    Content type: Research

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  30. Hyperphosphatasia with mental retardation syndrome (HPMRS) is a recessive disorder characterized by high blood levels of alkaline phosphatase together with typical dysmorphic signs such as cleft palate, intell...

    Authors: Layal Abi Farraj, Wassim Daoud Khatoun, Naji Abou Chebel, Victor Wakim, Katia Dawali and Michella Ghassibe-Sabbagh

    Citation: Diagnostic Pathology 2019 14:123

    Content type: Case Report

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  31. Teratocarcinosarcoma (TCS) is a rare aggressive tumor of the nasal cavity and paranasal sinuses and has both epithelial and two or more mesenchymal components. In other organs, 5 cases of ovarian tumors closel...

    Authors: Kozue Ito, Mitsutake Yano, Aiko Ogasawara, Maiko Miwa, Eito Kozawa and Masanori Yasuda

    Citation: Diagnostic Pathology 2019 14:122

    Content type: Case Report

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  32. Protein arginine methyltransferase-1 (PRMT1) is associated with the progression of various tumor types and the process of epithelial to mesenchymal transition (EMT). However, the expression of PRMT1 in renal c...

    Authors: Jelena Filipović, Martina Bosić, Sanja Ćirović, Maja Životić, Duško Dunđerović, Dejan Đorđević, Snežana Živković-Perišić, Aleksandar Lipkovski and Jasmina Marković-Lipkovski

    Citation: Diagnostic Pathology 2019 14:120

    Content type: Research

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  33. Gestational diabetes mellitus (GDM) leads to poor pregnancy outcomes. Strategies that improve trophoblast cell function are important methods for GDM treatment. This study aimed to investigate the expression a...

    Authors: Xuegui Zhou, Cuiping Xiang and Xiaoxia Zheng

    Citation: Diagnostic Pathology 2019 14:119

    Content type: Research

    Published on:

  34. Carboxypeptidase X, M14 family member 2 (CPXM2), has been associated with several human developmental disorders. However, whether CPXM2 is involved in oncogenesis or tumor progression remains unclear. Currentl...

    Authors: Xin Zhao, Ronghang Li, Qian Wang, Minfei Wu and Yanbing Wang

    Citation: Diagnostic Pathology 2019 14:118

    Content type: Research

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  35. Gastrointestinal stromal tumors (GISTs), a type of mesenchymal tumor in the gastrointestinal tract, are believed to be closely associated with PDGFRA and C-KIT mutations. Schwannoma in the stomach, which is an...

    Authors: Yuxin Li, Yongliang Teng, Xiaofei Wei, Zhuang Tian, Yuqing Cao, Xiaona Liu and Xiumei Duan

    Citation: Diagnostic Pathology 2019 14:116

    Content type: Case Report

    Published on:

  36. Primary cutaneous CD30+ lymphoproliferative disorders (pc-CD30-LPD) are a group of clonal T cell lymphoproliferative disorders that despite very similar tumor histology follow different and characteristic clin...

    Authors: Cristiane Rúbia Ferreira, Shuchun Zhao, José Antonio Sanches, Denis Miyashiro, Jade Cury-Martins, Raymundo Soares Azevedo, Maria C. N. Zerbini, Yasodha Natkunam and Dita Gratzinger

    Citation: Diagnostic Pathology 2019 14:115

    Content type: Research

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  37. Recent studies have shown that T cell-mediated cellular immune mechanisms play important roles in the progression of hepatitis B to liver cirrhosis, but the underlying mechanisms remain unclear. This present s...

    Authors: Yong-Ting Lan, Zhen-li Wang, Peng Tian, Xiao-Na Gong, Yu-Chen Fan and Kai Wang

    Citation: Diagnostic Pathology 2019 14:114

    Content type: Research

    Published on:

  38. Rapid (“warm”) autopsies of patients with advanced metastatic cancer provide important insight into the natural history, pathobiology and histomorphology of disease in treatment-resistant tumors. Plasmacytoid ...

    Authors: Caroline T. Simon, Stephanie L. Skala, Paul D. Killen, Javed Siddiqui, Xuhong Cao, Yuanyuan Qiao, Hikmat Al-Ahmadie, Sandra I. Camelo-Piragua, Jeffrey Jentzen, Arul M. Chinnaiyan, Saravana M. Dhanasekaran, Zachery R. Reichert and Rohit Mehra

    Citation: Diagnostic Pathology 2019 14:113

    Content type: Case Report

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  39. Translocation-associated renal cell carcinoma involving ALK (ALK-tRCC) is a rare subtype of adult renal cell carcinoma (RCC) reported in recent years. It was recognized as a group of emerging /provisional RCC ...

    Authors: Jing Yang, Lei Dong, Hong Du, Xiu-bo Li, Yan-xiao Liang and Guo-rong Liu

    Citation: Diagnostic Pathology 2019 14:112

    Content type: Case Report

    Published on:

  40. Epithelioid sarcoma (ES) is a rare malignant soft tissue tumor, commonly occurring in distal extremities, such as fingers, hands and wrists. For oncologists and surgeons, a female patient with enlarged axillar...

    Authors: Luyan Chen, Li Wang, Xiaochen Zhang, Minya Yao and Peifen Fu

    Citation: Diagnostic Pathology 2019 14:111

    Content type: Case Report

    Published on:

  41. Low-grade endometrial stromal sarcoma (ESS) is rare mesenchymal neoplasm, recently specified as harboring JAZF1–SUZ12 rearrangement. Typical JAZF1–SUZ12 ESS is slow growing, in which high uptake of fluorodeoxyglu...

    Authors: Koto Fujiishi, Shigenori Nagata, Rieko Kano, Chiaki Kubo, Maasa Shirayanagi, Megumi Ozaki, Takashi Yamamoto, Katsuyuki Nakanishi, Shoji Kamiura and Shin-ichi Nakatsuka

    Citation: Diagnostic Pathology 2019 14:110

    Content type: Case Report

    Published on:

  42. Laryngeal squamous cell carcinoma (LSCC) is considered to be a common malignancy of the head and neck with poor prognosis for its late diagnosis, metastasis and recurrence. Growing evidence demonstrates that t...

    Authors: Ruihua Fang, Yongjin Huang, Jinghua Xie, Jianzhong Zhang and Xiaobin Ji

    Citation: Diagnostic Pathology 2019 14:109

    Content type: Research

    Published on:

  43. Mcl-1, an anti-apoptotic member of bcl-2 family, together with cleaved poly (ADC-ribose) polymerase (c-PARP) can serve as a marker of cell apoptosis. Previously we reported that treatment of Mnk inhibitor CGP5...

    Authors: Qiuyuan Wen, Yuting Zhan, Hongmei Zheng, Hongjing Zang, Jiadi Luo, Yuting Zhang, Weiyuan Wang, Juan Feng, Junmi Lu, Lingjiao Chen and Songqing Fan

    Citation: Diagnostic Pathology 2019 14:108

    Content type: Research

    Published on:

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