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Diagnostic Pathology


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  1. Content type: Case Report

    Plasma cell myeloma (PCM) is a neoplasm of terminally differentiated B lymphocytes with molecular heterogeneity. Although therapy-related myeloid neoplasms are common in plasma cell myeloma patients after chem...

    Authors: Jonathon H. Gralewski, Ginell R. Post, Frits van Rhee and Youzhong Yuan

    Citation: Diagnostic Pathology 2018 13:15

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  2. Content type: Case Report

    Mast cell leukemia (MCL) is a very rare form of systemic mastocytosis (SM) and accounts for less than 0.5% of all mastocytosis. The diagnosis of MCL requires the presence of SM criteria, accompanied by leukemi...

    Authors: Yalin Zheng, Lin Nong, Li Liang, Wei Wang and Ting Li

    Citation: Diagnostic Pathology 2018 13:14

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  3. Content type: Research

    The DecisionDx-Melanoma test provides prognostic information for patients with cutaneous melanoma (CM). Using formalin-fixed paraffin-embedded primary tumor tissue, the RT-PCR-based test classifies patients in...

    Authors: Robert W. Cook, Brooke Middlebrook, Jeff Wilkinson, Kyle R. Covington, Kristen Oelschlager, Federico A. Monzon and John F. Stone

    Citation: Diagnostic Pathology 2018 13:13

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  4. Content type: Review

    The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer ty...

    Authors: Margarita Udall, Maria Rizzo, Juliet Kenny, Jim Doherty, SueAnn Dahm, Paul Robbins and Eric Faulkner

    Citation: Diagnostic Pathology 2018 13:12

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  5. Content type: Research

    Several studies have suggested that claudin proteins, which are the main components of tight junction structures, are related to the regulation of cell polarity and cell differentiation.

    Authors: Xiaowei Zhang, Haiming Wang, Qian Li, Yunpeng Liu, Peiqing Zhao and Tao Li

    Citation: Diagnostic Pathology 2018 13:11

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  6. Content type: Case Report

    Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare malignancy, recently recognized as a provisional entity by the World Health Organization. Although increasing data have been publis...

    Authors: Ricardo Garcia Pastorello, Felipe D’Almeida Costa, Cynthia A. B. T. Osório, Fabiana B. A. Makdissi, Stephania Martins Bezerra, Marina de Brot, Antonio Hugo J. F. M. Campos, Fernando Augusto Soares and José Vassallo

    Citation: Diagnostic Pathology 2018 13:10

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  7. Content type: Research

    Nephroblastoma or Wilms tumor is the most frequent kidney cancer in children and accounts for 98% of kidney tumors in this age group. Despite favorable prognosis, a subgroup of these patients progresses to rec...

    Authors: Ana Paula Percicote, Gabriel Lazaretti Mardegan, Elizabeth Schneider Gugelmim, Sergio Ossamu Ioshii, Ana Paula Kuczynski, Seigo Nagashima and Lúcia de Noronha

    Citation: Diagnostic Pathology 2018 13:9

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  8. Content type: Research

    Human intestinal spirochetosis (IS) has been recognized for decades, but whether it represents commensalism or a pathogenic process remains controversial. IS is diagnosed on routine stains with confirmation by...

    Authors: Rondell P. Graham, Bita V. Naini, Sejal S. Shah, Christina A. Arnold, Rajesh Kannangai, Michael S. Torbenson and Dora M. Lam-Himlin

    Citation: Diagnostic Pathology 2018 13:7

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  9. Content type: Research

    Programmed death ligand 1 (PD-L1) has shown potential as a therapeutic target in numerous solid tumors. Its prognostic significance has also been established in pancreatic ductal adenocarcinoma (PDAC). The pre...

    Authors: Xiaolong Liang, Jian Sun, Huanwen Wu, Yufeng Luo, Lili Wang, Junliang Lu, Zhiwen Zhang, Junchao Guo, Zhiyong Liang and Tonghua Liu

    Citation: Diagnostic Pathology 2018 13:5

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  10. Content type: Case Report

    IgG4-related disease often forms a mass and the affected lesion is clinically removed because the mass cannot be differentiated from a neoplasm. Affected lesions commonly occur in the pancreas, hepatobiliary t...

    Authors: Atsuko Masunaga, Fumihiro Ishibashi, Eitetsu Koh, Takashi Oide, Yasuo Sekine and Kenzo Hiroshima

    Citation: Diagnostic Pathology 2018 13:6

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  11. Content type: Research

    Identification of predictive molecular alterations in lung adenocarcinoma is essential for accurate therapeutic decisions. Although several molecular approaches are available, a number of issues, including tum...

    Authors: Eleonora Bonaparte, Chiara Pesenti, Laura Fontana, Rossella Falcone, Leda Paganini, Anna Marzorati, Stefano Ferrero, Mario Nosotti, Paolo Mendogni, Claudia Bareggi, Silvia Maria Sirchia, Silvia Tabano, Silvano Bosari and Monica Miozzo

    Citation: Diagnostic Pathology 2018 13:4

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  12. Content type: Case Report

    A proper balance between the activator and the repressor form of GLI3, a zinc-finger transcription factor downstream of hedgehog signaling, is essential for proper development of various organs during developm...

    Authors: Saki Ito, Riko Kitazawa, Ryuma Haraguchi, Takeshi Kondo, Ayaka Ouchi, Yasuo Ueda and Sohei Kitazawa

    Citation: Diagnostic Pathology 2018 13:1

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  13. Content type: Research

    The nucleolus is an organelle that is an ultrastructural element of the cell nucleus observed in H&E staining as a roundish body stained with eosin due to its high protein content. Changes in the nucleoli cyto...

    Authors: Piotr Donizy, Przemyslaw Biecek, Agnieszka Halon, Adam Maciejczyk and Rafal Matkowski

    Citation: Diagnostic Pathology 2017 12:88

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  14. Content type: Research

    Mounting evidence has shown that KRAS and BRAF are somatic mutations associated with low grade serous carcinoma (LGSC) of the ovary. However, the frequency of KRAS or BRAF mutation was variable in literatures,...

    Authors: Yan Xu, Rui Bi, Yaoxing Xiao, Xiaoyu Tu, Ming Li, Anqi Li, Ling Shan, Shuling Zhou and Wentao Yang

    Citation: Diagnostic Pathology 2017 12:87

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  15. Content type: Case Report

    Renal transplant recipients have increased risk for developing malignant diseases because of immunosuppression or donor-to-recipient transmission. Malignant rhabdoid tumor (MRT) is a rare, highly aggressive an...

    Authors: Jing Xiong, Tiefen Su, Pengcheng Zhu, Qilin Ao, Qiurong Ruan and Guoping Wang

    Citation: Diagnostic Pathology 2017 12:86

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  16. Content type: Case Report

    Although adenocarcinomas showing neuroendocrine differentiation or those mixed with high-grade neuroendocrine carcinoma (NEC) are sometimes encountered, composite tumors comprising neuroendocrine tumor (NET) G...

    Authors: Hiromi Kanno-Okada, Tomoko Mitsuhashi, Katsuhiro Mabe, Tadakazu Shimoda and Yoshihiro Matsuno

    Citation: Diagnostic Pathology 2017 12:85

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  17. Content type: Research

    Hematoxylin-eosin (HE) staining of a full-thickness rectal wall fragment is classically used for the diagnosis of Hirschsprung disease (HD). However, this technique requires large fragments for a better diagno...

    Authors: Suellen Serafini, Maria Mercês Santos, Ana Cristina Aoun Tannuri, Maria Claudia Nogueira Zerbini, Maria Cecília de Mendonça Coelho, Josiane de Oliveira Gonçalves and Uenis Tannuri

    Citation: Diagnostic Pathology 2017 12:84

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  18. Content type: Case Report

    Plasmablastic lymphoma (PBL) is relatively new clinical entity described as a distinct subtype of diffuse large B-cell lymphoma (DLBCL). It is characterized by its aggressive nature and proliferation of large ...

    Authors: Ita Hadžisejdić, Emina Babarović, Luka Vranić, Antica Duletić Načinović, Ksenija Lučin, Maja Krašević and Nives Jonjić

    Citation: Diagnostic Pathology 2017 12:83

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  19. Content type: Case Report

    KIAA1549-BRAF fusion is the most common genetic event in pilocytic astrocytoma (PA), and leads to activation of the mitogen activated protein kinase (MAPK) signaling pathway. Fusions o...

    Authors: Jeffrey Helgager, Hart G. Lidov, Navin R. Mahadevan, Mark W. Kieran, Keith L. Ligon and Sanda Alexandrescu

    Citation: Diagnostic Pathology 2017 12:82

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  20. Content type: Case Report

    TP53 mutations are rarely identified in low grade endometrioid carcinoma of the endometrium, and their pathogenic significance in such tumors is evidenced by the fact that TP53 aberrat...

    Authors: Oluwole Fadare and Vinita Parkash

    Citation: Diagnostic Pathology 2017 12:81

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  21. Content type: Research

    Steatosis is routinely assessed histologically in clinical practice and research. Automated image analysis can reduce the effort of quantifying steatosis. Since reproducibility is essential for practical use, ...

    Authors: André Homeyer, Patrik Nasr, Christiane Engel, Stergios Kechagias, Peter Lundberg, Mattias Ekstedt, Henning Kost, Nick Weiss, Tim Palmer, Horst Karl Hahn, Darren Treanor and Claes Lundström

    Citation: Diagnostic Pathology 2017 12:80

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  22. Content type: Case Report

    Maffucci syndrome is a congenital, non-hereditary mesodermal dysplasia characterized by multiple enchondromas and hemangiomas. The presence of visceral vascular lesions in this syndrome is exceedingly rare.

    Authors: Xiao-Dan Huang, Hao-Sen Jiao, Zheng Yang, Chuang-Qi Chen, Yu-Long He and Xin-Hua Zhang

    Citation: Diagnostic Pathology 2017 12:79

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