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COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

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  1. Endoscopic submucosal dissection (ESD) is a novel endoscopic treatment for early esophageal adenocarcinoma (EAC). The western pathologists’ experience with ESD specimens remains limited. This study aimed to co...

    Authors: Sadhna Dhingra, Firas Bahdi, Sarah B. May and Mohamed O. Othman

    Citation: Diagnostic Pathology 2021 16:111

    Content type: Research

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  2. Immunotherapy is an important treatment in oncology, but only a fraction of patients with head and neck squamous cell carcinoma (HNSCC) benefit from it. Therefore, the aim of this study was to identify predict...

    Authors: Xuanli Xu, Rongrong Li, Lin Zhang, Guopei Zhu, Dandan Ren, Lijia Wu and Xiaoli Gong

    Citation: Diagnostic Pathology 2021 16:110

    Content type: Research

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  3. Lymphovascular invasion (VI) is an established prognostic marker for many cancers including bladder cancer. There is a paucity of data regarding whether the prognostic significance of lymphatic invasion (LVI) ...

    Authors: Birgitte Carlsen, Tor Audun Klingen, Bettina Kulle Andreassen and Erik Skaaheim Haug

    Citation: Diagnostic Pathology 2021 16:109

    Content type: Research

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  4. Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) of the pancreas are extremely rare. Their pathogenesis and molecular landscape are largely unknown. Here, we report a case of mixed pancreatic intraduc...

    Authors: Jingci Chen, Pengyan Wang, Ke Lv and Weixun Zhou

    Citation: Diagnostic Pathology 2021 16:108

    Content type: Case Report

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  5. Hereditary papillary renal cell carcinoma (HPRCC) is a rare autosomal dominant disease characterized by the development of multiple and bilateral papillary type I renal cell carcinomas (RCC) and papillary aden...

    Authors: Sophie Ferlicot, Pierre-Alexandre Just, Eva Compérat, Etienne Rouleau, Frédérique Tissier, Christophe Vaessen and Stéphane Richard

    Citation: Diagnostic Pathology 2021 16:107

    Content type: Case Report

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  6. Microsatellite instability occurs due to a series of mutations in the DNA pairing error repair (Mismatch repair; MMR) genes, which can affect germ cells as occurs in Lynch syndrome, whose patients are at high ...

    Authors: Eduardo Sobrino-Reig, Telma Meizoso, Jesús García, David Varillas-Delgado and Yasmina B. Martin

    Citation: Diagnostic Pathology 2021 16:106

    Content type: Research

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  7. Cervical cancer (CC) endangers women’s health in the world range. Accumulating studies have revealed the crucial regulatory role of long non-coding RNAs (lncRNAs) in multiple malignancies, including CC. Our st...

    Authors: Jihui Gu, Yi Liu, Ting Qi, Weiwei Qian, Dongdong Hu and Wen Feng

    Citation: Diagnostic Pathology 2021 16:105

    Content type: Research

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  8. We present a unique case of primary breast CD20-positive extranodal NK/T cell lymphoma with stomach involvement in a young Chinese female patient.

    Authors: Ying Zhang, Kuansong Wang, Qian Tan, Keda Yang, Dengshu Wu, Yajing Xu, Xielan Zhao and Zhiping Jiang

    Citation: Diagnostic Pathology 2021 16:103

    Content type: Case Report

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  9. Detection of the tumor-specific EWSR1/FUS-ETS fusion gene is essential to diagnose Ewing sarcoma. Reverse transcription–polymerase chain reaction (RT–PCR) and fluorescence in situ hybridization are commonly used ...

    Authors: Hitomi Ueno-Yokohata, Hajime Okita, Keiko Nakasato, Chikako Kiyotani, Motohiro Kato, Kimikazu Matsumoto, Nobutaka Kiyokawa, Atsuko Nakazawa and Takako Yoshioka

    Citation: Diagnostic Pathology 2021 16:102

    Content type: Research

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  10. The clinicopathological characteristics and prognostic factors in nodal peripheral T-cell lymphomas (PTCLs) with two or more T follicular helper markers (TFH+) are not adequately investigated.

    Authors: Yasuhito Mihashi, Shoichi Kimura, Hiromi Iwasaki, Yumi Oshiro, Yasushi Takamatsu, Shigeto Kawauchi, Shohei Shimajiri, Kenji Ishizuka and Morishige Takeshita

    Citation: Diagnostic Pathology 2021 16:101

    Content type: Research

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  11. TP53 mutation is found frequently in therapy related acute myeloid leukemia (AML)/ myelodysplastic syndrome (MDS), AML and MDS patients with monosomy or complex karyotype. However, the prevalence and treatment...

    Authors: Pimjai Niparuck, Pornnapa Police, Phichchapha Noikongdee, Kanchana Siriputtanapong, Nittaya Limsuwanachot, Budsaba Rerkamnuaychoke, Suporn Chuncharunee and Teerapong Siriboonpiputtana

    Citation: Diagnostic Pathology 2021 16:100

    Content type: Research

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  12. Extraosseous benign notochordal cell tumor is extremely rare, and there are only five reported cases worldwide. The presented case of pulmonary primary benign notochordal cell tumor is the sixth case, but the ...

    Authors: Kai Song, Xiaojing Ma, Jinghong Xu and Lirong Chen

    Citation: Diagnostic Pathology 2021 16:99

    Content type: Case Report

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  13. Aurora-A kinase is important for cellular proliferation and is implicated in the tumorigenesis of several malignancies, including of the ovary. Information regarding the expression patterns of Aurora-A in norm...

    Authors: Khaled J. Alkhateeb, Jason E. Crane, Müge Sak, Caitlin J. Jorgensen, James P. O’Donnell, Cory T. Zumbar, Jason A. Wozniak, Clarence R. Salazar, Anil V. Parwani and Norman L. Lehman

    Citation: Diagnostic Pathology 2021 16:98

    Content type: Research

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  14. Adult-onset Still’s disease (AOSD) often presents with systemic multiple lymphadenopathy. In addition to the common paracortical and mixed patterns in AOSD lymph node histopathological features, other morpholo...

    Authors: Zhonghua Huang, Hua Xu, Qinqin Min, Zhenguo Li, Jiaxin Bi, Lingyun Liu and Yingying Liang

    Citation: Diagnostic Pathology 2021 16:97

    Content type: Case Report

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  15. The fibroblast growth factor receptor substrate 2 (FRS2) gene is located close to MDM2 and CDK4 within the 12q13-15 chromosomal region. FRS2 gene was recently found to be consistently amplified in atypical lipoma...

    Authors: Wenyi Jing, Ting Lan, Yan Qiu, Ran Peng, Yang Lu, Huijiao Chen, Min Chen, Xin He, Chen Chen and Hongying Zhang

    Citation: Diagnostic Pathology 2021 16:96

    Content type: Research

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  16. The precursors of clear cell endometrial carcinoma (CC-EC) are still undefined. Here, we deal with the diagnostic issues related to CC-EC precursors by presenting a morphological, immunophenotypical and molecu...

    Authors: Angela Santoro, Antonio Travaglino, Frediano Inzani, Damiano Arciuolo, Giuseppe Angelico, Nicoletta D’Alessandris, Giulia Scaglione, Michele Valente, Maurizio Martini, Antonio Raffone and Gian Franco Zannoni

    Citation: Diagnostic Pathology 2021 16:95

    Content type: Case Report

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  17. Immune checkpoint proteins, especially PD-L1 and PD-1, play a crucial role in controlling the intensity and duration of the immune response, thus preventing the development of autoimmunity. These proteins play...

    Authors: Mohammed Akhtar, Sameera Rashid and Issam A. Al-Bozom

    Citation: Diagnostic Pathology 2021 16:94

    Content type: Review

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  18. Circular RNAs (circRNAs) have become a hot topic in the area of tumor biology due to its closed structure and the post-transcriptional regulatory effect. This study aims to clarify the roles of circRNA nuclear...

    Authors: Chuang Li, Lijuan Zhu, Lijun Fu, Mingli Han, Ya Li, Zhaozhong Meng and Xinguang Qiu

    Citation: Diagnostic Pathology 2021 16:93

    Content type: Research

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  19. Fine-needle aspiration cytology (FNAC) is a basic diagnostic tool for thyroid nodules. However, 15–30% of nodules are cytologically indeterminate. Midkine (MK), a pleiotropic growth factor, is often upregulate...

    Authors: Le Zhou, Jinxi Jiang, Yantao Fu, Daqi Zhang, Tong Li, Qingfeng Fu, Chao Yan, Yifan Zhong, Gianlorenzo Dionigi, Nan Liang and Hui Sun

    Citation: Diagnostic Pathology 2021 16:92

    Content type: Research

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  20. The rarity of juvenile psammomatoid ossifying fibroma (JPOF) and lack of cytogenetic studies prompted us to report a novel SETD2 gene mutation in a benign odontogenic tumour.

    Authors: A. Toferer, A. Truschnegg, K. Kashofer, C. Beham-Schmid and A. Beham

    Citation: Diagnostic Pathology 2021 16:91

    Content type: Case Report

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  21. Acute fibrinous and organizing pneumonia (AFOP) is a rare histologic interstitial pneumonia pattern characterized by the intra-alveolar fibrin deposition and organizing pneumonia. Its clinical characteristics ...

    Authors: Haihong Chen, Yukun Kuang, Xinyan Huang, Ziyin Ye, Yangli Liu, Canmao Xie and Ke-Jing Tang

    Citation: Diagnostic Pathology 2021 16:90

    Content type: Case Report

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  22. Secretory breast carcinoma is an uncommon subset of breast cancer that usually has a favorable outcome. Although initially described in children, it also occurs in adults where it may metastasize, possibly res...

    Authors: Jing Lian, Li-Xia Wang, Jiang-hong Guo, Peng Bu, Yan-feng Xi and Ke-ming Yun

    Citation: Diagnostic Pathology 2021 16:89

    Content type: Case Report

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  23. COVID-19, the disease caused by the novel coronavirus SARS-CoV-2, is a severe systemic thrombotic syndrome that emerged in 2019, with an ensuing pandemic.

    Authors: Giovanna Giordano, Chiara Petrolini, Emilia Corradini, Nicoletta Campanini, Susanna Esposito and Serafina Perrone

    Citation: Diagnostic Pathology 2021 16:88

    Content type: Case Report

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  24. Thyroid tumors are often difficult to histopathologically diagnose, particularly follicular adenoma (FA) and follicular carcinoma (FC). Papillary carcinoma (PAC) has several histological subtypes. Periostin (P...

    Authors: Kimihide Kusafuka, Masaru Yamashita, Tomohiro Iwasaki, Chinatsu Tsuchiya, Aki Kubota, Kazuki Hirata, Akinori Murakami, Aya Muramatsu, Kazumori Arai and Makoto Suzuki

    Citation: Diagnostic Pathology 2021 16:86

    Content type: Short report

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  25. The incidence of papillary thyroid carcinoma (PTC) has been steadily increasing over the past decades. Hashimoto’s thyroiditis (HT) is the most common autoimmune disease, and is related to the pathogenesis of ...

    Authors: Chumeng Zhu, Yuechu Dai, Hui Zhang, Yanyun Ruan, Yong Zhou, Yingjie Dai, Lilong Fan, Tianjun Jia, Hongsheng Lu and Qi Chen

    Citation: Diagnostic Pathology 2021 16:84

    Content type: Research

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  26. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by hamartomas in multiple organs associated with germline mutations in TSC1 and TSC2, including exonic, intronic, or mosaic mutatio...

    Authors: Bogyeong Han, Juhwan Lee, Yoon Jin Kwak, Hyun-Young Kim, Kwang Hoon Lee, Yumi Shim, Hyunju Lee and Sung-Hye Park

    Citation: Diagnostic Pathology 2021 16:83

    Content type: Case Report

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  27. A high incidence of malignant tumors, such as post-transplant lymphoproliferative disorders (PTLD), Kaposi sarcoma, and renal cancer is common in solid organ and bone marrow transplant recipients. However, mye...

    Authors: Danyang Wu, Xiaoxuan Lu, Xiaojing Yan and Ran Gao

    Citation: Diagnostic Pathology 2021 16:82

    Content type: Case Report

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  28. Congenital hepatic fibrosis (CHF) is a rare inherited form of ductal plate malformation associated with polycystic kidney disease. The diagnosis requires histopathologic confirmation, but can be challenging to...

    Authors: Irene Y. Chen, Christa L. Whitney-Miller and Xiaoyan Liao

    Citation: Diagnostic Pathology 2021 16:81

    Content type: Research

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  29. A definitive diagnosis of malignant peripheral nerve sheath tumor (MPNST) is challenging, especially in cases without neurofibromatosis 1 (NF1), because MPNST lacks specific markers on immunohistochemistry (IHC).

    Authors: Shintaro Sugita, Tomoyuki Aoyama, Makoto Emori, Tomomi Kido, Tomoko Takenami, Kodai Sakuraba, Kotomi Terai, Taro Sugawara, Mitsuhiro Tsujiwaki and Tadashi Hasegawa

    Citation: Diagnostic Pathology 2021 16:79

    Content type: Research

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  30. Histopathological classification of Wilms tumors determines treatment regimen. Machine learning has been shown to contribute to histopathological classification in various malignancies but requires large numbe...

    Authors: Jikke J. Rutgers, Tessa Bánki, Ananda van der Kamp, Tomas J. Waterlander, Marijn A. Scheijde-Vermeulen, Marry M. van den Heuvel-Eibrink, Jeroen A. W. M. van der Laak, Marta Fiocco, Annelies M. C. Mavinkurve-Groothuis and Ronald R. de Krijger

    Citation: Diagnostic Pathology 2021 16:77

    Content type: Research

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  31. First described in 1955 Primary mediastinal seminomas are rare. Only 1–4% of mediastinal tumours are germ cell tumors; majority of which are teratomas. They typically present in men aged between 20 and 40 year...

    Authors: Charlotte Holmes, Peh Sun Loo and Sion Barnard

    Citation: Diagnostic Pathology 2021 16:76

    Content type: Case Report

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  32. There are recognised potential pitfalls in digital diagnosis in urological pathology, including the grading of dysplasia. The World Health Organisation/International Society of Urological Pathology (WHO/ISUP) ...

    Authors: Lisa Browning, Richard Colling and Clare Verrill

    Citation: Diagnostic Pathology 2021 16:75

    Content type: Short report

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  33. With widespread clinical application of imaging techniques, renal space-occupying lesions have been identified at an increasing frequency. Here, we report two rare cases, Castleman disease (CD) and IgG4-relate...

    Authors: Bolong Liu, Yong Huang, Luying Tang, Jiexia Guan, Xiangfu Zhou and Hailun Zhan

    Citation: Diagnostic Pathology 2021 16:74

    Content type: Case Report

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  34. Fusions of neurotrophic tropomyosin receptor kinase genes NTRK1, NTRK2 and NTRK3 with various partner genes occur in both common and rare tumours and are of paramount predictive value due to the availability of v...

    Authors: Florian Wagner, Ralf Greim, Kathrin Krebs, Finn Luebben and Arno Dimmler

    Citation: Diagnostic Pathology 2021 16:73

    Content type: Case Report

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  35. Pancreaticobiliary maljunction (PBM) is a condition characterized by chronic inflammation due to refluxed pancreatic juice into the biliary tract that is associated with an elevated risk of biliary tract cance...

    Authors: Yasuhiro Kuraishi, Takeshi Uehara, Takashi Muraki, Mai Iwaya, Yasuhiro Kinugawa, Tomoyuki Nakajima, Takayuki Watanabe, Yusuke Miyagawa and Takeji Umemura

    Citation: Diagnostic Pathology 2021 16:72

    Content type: Research

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  36. Histological images show strong variance (e.g. illumination, color, staining quality) due to differences in image acquisition, tissue processing, staining, etc. This can impede downstream image analysis such a...

    Authors: Marlen Runz, Daniel Rusche, Stefan Schmidt, Martin R. Weihrauch, Jürgen Hesser and Cleo-Aron Weis

    Citation: Diagnostic Pathology 2021 16:71

    Content type: Research

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  37. Quick and reliable testing of EGFR and KRAS is needed in non-small cell lung cancer (NSCLC) to ensure optimal decision-making for targeted therapy. The Idylla™ platform was designed for Formalin-Fixed Paraffin-Em...

    Authors: Saskia Offerman, Clemens F. Prinsen, Ageeth Knol, Natalie Methorst, Jeanette Kamphorst and Maarten Niemantsverdriet

    Citation: Diagnostic Pathology 2021 16:70

    Content type: Short report

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  38. Gastric-type endocervical adenocarcinoma is rare but the most common subtype of cervical adenocarcinoma not associated with human papillomavirus. It is more aggressive with a shorter five-year survival rate co...

    Authors: Anna Radomska, Daniel Lee, Heather Neufeld, Nancy Korte, Emina Torlakovic, Anita Agrawal and Rajni Chibbar

    Citation: Diagnostic Pathology 2021 16:68

    Content type: Research

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  39. Sudden cardiac death (SCD) remains a great health threat and diagnostic challenge, especially those cases without positive autopsy findings. Molecular biomarkers have been urgently needed for the diagnosis of ...

    Authors: Fengping Yan, Yuanyuan Chen, Xing Ye, Fu Zhang, Shiquan Wang, Le Zhang and Xiaoting Luo

    Citation: Diagnostic Pathology 2021 16:67

    Content type: Research

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  40. Certain gastric cancers exhibit some primitive phenotypes, which may indicate a high malignancy. In histologically differentiated early gastric cancer (EGC), the presence and the clinicopathological significan...

    Authors: Zhi-Yi Zhou, Jie Sun, Qing Guo, Hai-Bin Zhao and Zhi-Hua Zhou

    Citation: Diagnostic Pathology 2021 16:66

    Content type: Research

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  41. Lipoprotein glomerulopathy (LPG) is a rare autosomal dominant disease caused by mutations in APOE, the gene which encodes apolipoprotein E. LPG mainly affects Asian individuals, however occasional cases have also...

    Authors: Joaquim Nelito da Silveira-Neto, Guilherme Jinson de Oliveira Ahn, Precil Diego Miranda de Menezes Neves, Vinicius Augusto Ferreira Baptista, Stanley de Almeida Araújo, David Campos Wanderley, Andréia Watanabe, Elieser Hitoshi Watanabe, Neide Missae Murai, Eny Maria Goloni Bertollo, Osvaldo Merege Vieira-Neto, Márcio Dantas, Sergio Ricardo de Antônio, Roberto Silva Costa, Maria Alice Sperto Ferreira Baptista, Miguel Moysés-Neto…

    Citation: Diagnostic Pathology 2021 16:65

    Content type: Case Report

    Published on:

  42. Diffuse malignant peritoneal mesothelioma (DMPM) is a rare malignant neoplasm with poor survival that shares some similarities with the best-known pleural variant, pleural mesothelioma. The recent European Ref...

    Authors: Federica Pezzuto, Luigi Vimercati, Francesco Fortarezza, Andrea Marzullo, Antonio Pennella, Domenica Cavone, Alessandra Punzi, Concetta Caporusso, Antonio d’Amati, Teresa Lettini and Gabriella Serio

    Citation: Diagnostic Pathology 2021 16:64

    Content type: Short report

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  43. The distribution of mucin phenotypes and their relationship with clinicopathological features in early differentiated gastric adenocarcinomas in a Chinese cohort are unknown. We aimed to investigate mucin phen...

    Authors: Kai Song, Qi Yang, Yu Yan, Xiaoyan Yu, Kanlun Xu and Jinghong Xu

    Citation: Diagnostic Pathology 2021 16:62

    Content type: Research

    Published on:

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